Mechanisms of Intellectual Disability: from genes to treatment

Intellectual disability, also referred as Mental Retardation (ID/MR), is the most common developmental disorder, with a prevalence of 1-3%, and includes a highly diverse group of cognitive disorders. Gene defects account for about half of all patients and mutations have been identified in more than 400 genes, of which 97 are in the X chromosome. The rapid advancing in the knowledge of genes mutated or dysregulated in ID/MR and the application of new system and bio-informatics technologies to the field will bring to the identification of pathways common to different forms of ID. Unravelling these common pathways might be extremely important for the future cure of ID because drugs targeting similar pathways might be used for different form of ID, most of which are singularly rare and thus difficult to attract pharmaceutical research.
The conference represents the second edition of JMC dedicated to ID/MR and is based on the highly successful formula of the previous one which brought together geneticists involved in the search for MR genes and neuroscientists experts of structure and mechanisms of function of synapses. Other topics such as epigenetics, neurogenesis, role of interneurons and circuit formation, whose importance in the mechanisms of ID have recently emerged, will be covered in different sessions.
While the present conference is based on the consideration that exchanging information between geneticists and neuroscientists is useful for the advancement in the pathophysiology of ID/MR, a special emphasis will be given to the real possibility that a cure should follow their neurobiological understanding.
The conference will cover the following topics:
Genetics and Epigenetics of cognition and intellectual disorders
Cloning and characterization of genes
RNA metabolism and ID
Structures and plasticity of synapses and ID
Neurogenesis and synaptogenesis
Migration, interneurons and ID
Neuronal circuit development and ID
Towards a cure: lessons from animal models
+ show speakers and program
BARDONI Barbara (Nice, France)
Molecular pathways involved in Fragile X syndrome in developing and adult brain
BEN-ARI Yehezkel (Marseille, France)
Developmental disorders recapitulate ontogenesis: treating autism with a diuretic
BROCCOLI Vania (Milano, Italy)
The atypical Rett syndrome molecule CDKL5 is necessary for correct neuronal spine development and synapse formation
BUREAU Ingrid (Marseille, France)
Plasticity defects and learning in Fragile X mutant mice
CANCEDDA Laura (Genoa, Italy)
Non-hyperpolarizing GABA and cortical maldevelopment
CATANIA Maria Vincenza (Catania, Italia)
Role of mGluR in neuronal development: implication for an early treatment of neurodevelopmental disorders
CHELLY Jamel (Paris, France)
Neuronal migration disorders and Intellectual disability
COLLEAUX Laurence (Paris, France)
Unravelling the molecular and pathophysiological bases of autosomal recessive intellectual disability
FAGNI Laurent (Montpellier, France)
Modulation of excitatory synaptic transmission by glutamate receptor scaffolding proteins
FRANCIS Fiona (Paris, France)
Molecular, morphological and functional analysis of hippocampal lamination defects in the mouse
GECZ Josef (Adelaide, Australia)
mRNA surveillance and learning and memory
GRANT Seth (Cambridge, United Kingdom)
The evolution of cognition and the price of mutation
KIEBLER Michael (Vienna, Austria)
The role of RNA granules in dendritic mRNA localization
LALANDE Marc (Farmington, USA)
Application of induced pluripotent stem cell (iPSC) technology to imprinting disorders of human chromosome 15q11-q13
LLEDO Pierre-Marie (Paris, France)
The hipe and hope of adult neurogenesis and mental illness
MANSUY Isabelle (Zürich, Switzerland)
Epigenetics underpinning of cognitive and behavioral disorders: Modeling in animals
MARIN Oscar (Alicante, Spain)
Cortical interneuron development in health and disease
MICHAUD Jacques (Montreal, Canada)
Genetics of autosomic dominant forms of intellectual disability
MULLE Christophe (Bordeaux, France)
Impaired morphofunctional maturation of hippocampal mossy fiber synapses in mouse models of learning disability
PREAT Thomas (Paris, France)
Genetics of learning and memory and brain imaging in Drosophila
RAYMOND Lucy (Cambridge, United Kingdom)
Genetics approaches to identify genes that cause Intellectual Disability
SCHRATT Gerhard (Marburg, Germany)
The role of microRNAs in synapse development, plasticity and dysfunction
SILVA Alcino (Los Angeles, USA)
Molecular and cellular mechanisms underlying cognitive deficits associated with Rasopathies
SÜDHOF Thomas (Stanford, USA)
Neurexins and neuroligin: function and dysfunction
TRILLER Antoine (Paris, France)
Alterations of molecular dynamic in neurodegenerative synaptopathies
VAN AELST Linda (Cold Spring Harbor, USA)
The Rho-linked mental retardation protein Oligophrenin-1 controls synapse formation and plasticity
VAN BOKHOVEN Hans (Nijmegen, The Netherlands)
Genetic and epigenetic networks in intellectual disabilities

3 Oct - 7 Oct 2012
Roscoff
France
meeting website