The Hippo Tumor Suppressor Network: From Organ Size Control to Stem Cells and Cancer

Metazoans have evolved pathways that regulate the size of organs. One of the key pathways is known as the Hippo pathway. Research on the Hippo pathway has grown exponentially during the past 8 years, revealing a complex signaling network. When components of the network are affected by genetic lesions or are abnormally expressed, this leads to cancer. The main effectors of this pathway, YAP and TAZ, are transcriptional co-activators, which act as stemness factors and potent oncogenes. The applicants co-organized two Hippo workshops in Rome, Italy in 2009 & 2010, during which several paradoxes in the field emerged. We realized that the fast progress in this field is due to an active dialog between Drosophila geneticists and mammalian signalers. (See meeting reports in Science Signaling and CDD). The overwhelming interest of researchers in the function of the Hippo pathway in stem cells and cancer prompted us to seek a larger forum. At the proposed meeting we aim to: (i) Define why YAP and TAZ function as either oncogenes or tumor suppressors; (ii) Identify membrane complexes, which activate the Hippo pathway in mammals, as the orthology with the fly receptors is not clear; (iii) Define targets for small molecule inhibitors and activators within pathway components based on structured modules, including WW, PDZ and SARAH domains. INNOVATION: The meeting will bring together Drosophila geneticists, basic and clinical cancer researchers, and the stem cell research community. It should consolidate the emerging field and have an impact on development of new cancer therapies.
+ show speakers and program
SUNDAY, MAY 19

16:00—20:00
Arrival and Registration

Regency Grand Foyer

MONDAY, MAY 20

07:00—08:00
Breakfast

Regency Grand IV-VI
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Joseph Avruch, Massachusetts General Hospital, USA
How Does the Core Kinase Cassette of the Hippo Pathway Control the Yki, YAP and TAZ Effectors?

09:00—11:15
Membrane and Upstream Signals
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Helen McNeill, Samuel Lunenfeld Research Institute, Canada
Signals from FAT Receptors in Flies and in Mammals

Fernando D. Camargo, Children's Hospital Boston, USA
Hippo Pathway Models in Mice: Stem Cells, Diseases and Emerging Strategies for Therapies

Xaralabos Varelas, Boston University, USA
Cross-Talk between Hippo, TGF-beta and Wnt Signaling Pathways

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

Regency Grand Foyer
11:15—13:00
Poster Setup

Regency Grand IV-VI
13:00—22:00
Poster Viewing

Regency Grand IV-VI

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Regency Grand Foyer
17:00—19:00
Hippo in Flies and Mammals: Orthology and Diversity
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Duojia (DJ) Pan, Johns Hopkins University School of Medicine, USA
Crumbs and Merlin Signaling in Flies and Mammals

Nicolas Tapon, Cancer Research UK London Research Institute, UK
New Approaches to Define the Extended Network of the Hippo Pathway in Drosophila Fly - Implications for the Mammalian Pathway

Joan S. Brugge, Harvard Medical School, USA
The Role of YAP Oncogene in Cytokinesis

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Regency Grand IV-VI
19:30—22:00
Poster Session 1

Regency Grand IV-VI

TUESDAY, MAY 21

07:00—08:00
Breakfast

Regency Grand IV-VI
08:00—11:00
Junctional Complexes and the Hippo Pathway
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Joseph L. Kissil, Wistar Institute, USA
Angiomotins, Merlin and Tumor Suppression Mechanisms in Mice and Men

Wan Jin Hong, Institute of Molecular and Cell Biology, Singapore
Angiomotins Use YAP/TAZ as a Shuttle between Junctional Complexes and Nuclear Signaling

Georg A. Halder, Katholieke Universiteit Leuven, Belgium
Regulation of the Hippo Pathway by Cell Polarity and Mechanical Forces

Hiroshi Sasaki, Kumamoto University, Institute of Molecular Embryology and Genetics, Japan
The Role of YAP and Hippo Pathway in Early Mouse Development

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Regency Grand Foyer
11:00—13:00
Poster Setup

Regency Grand IV-VI
13:00—22:00
Poster Viewing

Regency Grand IV-VI

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Regency Grand Foyer
17:00—19:00
Hippo Network in Organ Size Control
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Junichi Sadoshima, University of Medicine and Dentistry of New Jersey, USA
Hippo-Lats and YAP in Heart Development

Laura Johnston, Columbia University, USA
Organ Size Homeostasis Regulated by Myc and Yki

Muhammad Al-Hajj, GlaxoSmithKline, USA
Hippo Pathway in Cancer Drug Discovery

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Regency Grand IV-VI
19:30—22:00
Poster Session 2

Regency Grand IV-VI

WEDNESDAY, MAY 22

07:00—08:00
Breakfast

Regency Grand IV-VI
08:00—11:00
Deregulation of Hippo Pathway in Cancer
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Kieran Harvey, Peter MacCallum Cancer Centre, Australia
The Hippo Pathway, Tissue Growth and Cancer

Yael Aylon, Weizmann Institute of Science, Israel
Cooperation between ASPP1 and LATS2 in Tumor Suppression

Giovanni Blandino, Regina Elena Cancer Institute, Italy
Mechanisms by which cis-platin Treatment of Tumors Affects Hippo Pathway Signaling

Stefano Piccolo, University of Padua, Italy
Regulation of YAP and TAZ by Tissue Architecture

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Regency Grand Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Regency Grand Foyer
17:00—19:00
From Structure-Function Analysis to Details of the Mechanisms that Govern Hippo Signaling
Registered attendees can view abstracts starting on 04/19/2013

Regency Grand I-III
Tony Pawson, Samuel Lunenfeld Research Institute, Canada
Regulation of Rho GTPases and Kinases in Hippo Signaling

Kun-Liang Guan, University of California, San Diego, USA
YAP/TAZ-TEAD Complex and Transcriptional Program of Proliferation

Marius Sudol, Weis Center for Research, USA
Hippo Pathway as the WW Domain-Mediated Network of Signals

19:00—20:00
Social Hour w/ Lite Bites

Regency Grand IV-VI
20:00—23:00
Entertainment

Regency Grand IV-VI

THURSDAY, MAY 23


Departure


*Session Chair †Speaker invited, not yet responded.

19 May - 23 May 2013
Monterey
United States of America
meeting website