The Innate Immune Response in the Pathogenesis of Infectious Disease

The rational development of immunological interventions that are effective for treating or preventing infectious diseases is still on its infancy. For decades, the majority of the studies on immunopathogenesis have dealt with physical damage and inflammation, primarily mediated by the adaptive immune system. The main focus of the program will be on the interface of the innate immunity and microbial pathogens, as a key step that is determinant of protective versus deleterious immune responses, and thereby of the outcome of disease. This meeting will promote discussions on fundamental concepts as well as new advances in the role of innate immunity in host resistance and pathogenesis of infectious diseases, with significant emphasis on infections of the tropics. Investigators from different areas, such as biochemistry, cell biology, immunology, microbiology, parasitology, infectious diseases, tropical medicine and biotechnology will be included to encourage the discussion of interdisciplinary concepts and new directions for the field. This is the first of a series of Keystone Symposia meetings to be held in Brazil, and should also foster the participation of Latin American students and scientists. The close interaction of these participants with leading international experts in the field should lead to a stimulating atmosphere that we hope will promote the development of new South-North collaborations and research networks.




This meeting is part of the Keystone Symposia Global Health Series.

Global Health Travel Award Deadline: December 11, 2012
+ show speakers and program
FRIDAY, MAY 10

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session
Registered attendees can view abstracts starting on 04/10/2013

* Rodrigo Corrêa-Oliveira, FIOCRUZ Minas, Brazil
Keystone Brazil and the Challenges of Global Tropical Diseases

Jules A. Hoffmann, Institute of Cellular and Molecular Biology, France
Innate Immune Pathways in Drosophila

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases


SATURDAY, MAY 11

07:30—08:30
Breakfast

08:00—10:00
Poster Setup

08:30—11:30
Innate Immune Recognition
Registered attendees can view abstracts starting on 04/10/2013

Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK
Myeloid C-Type Lectin Receptors in Pathogen Recognition and Host Defense

Vishva M. Dixit, Genentech, Inc., USA
Inflammasome Activation

Kate A. Fitzgerald, University of Massachusetts Medical School, USA
Immune Surveillance from the Cytosol

Julie Magarian Blander, Mount Sinai School of Medicine, USA
Detecting and Responding to Microbial Viability

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

11:30—12:30
Lunch

12:00—14:30
Poster Session 1

14:30—16:30
Workshop 1: Innate Recognition and Microbial Pathogenesis

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Innate Immunity in Vectors
Registered attendees can view abstracts starting on 04/10/2013

* Elena A. Levashina, Max Planck Institute for Infection Biology, Germany
Mechanisms of Innate Resistance to Malaria Parasites in the Mosquito

George Dimopoulos, Johns Hopkins University, USA
Innate and Microbiota-Mediated Control of Dengue Virus in Mosquitoes

David L. Sacks, NIAID, National Institutes of Health, USA
Influence of Vector Transmission on the Innate Immune Response to Leishmania major

Short Talk Chosen from Abstracts

19:00—
On Own for Dinner


SUNDAY, MAY 12

07:30—08:30
Breakfast

08:30—11:30
Innate Lymphoid Cells (ILC) and Mucosal Immunity
Registered attendees can view abstracts starting on 04/10/2013

* Fiona M. Powrie, University of Oxford - NDM, UK
Innate Regulation of Intestinal Mucosal Inflammation

David Artis, University of Pennsylvania School of Medicine, USA
ILC in Regulation of Mucosal Immune Responses

Dan R. Littman, New York University School of Medicine, USA
Immune Homeostasis and Host Protection by Commensal Bacteria

Marco Colonna, Washington University School of Medicine, USA
NK Cells in Innate Immune Responses in Mucosal Sites

Short Talk(s) Chosen from Abstracts

09:50—10:10
Coffee Break

11:30—13:00
Poster Setup

11:30—
On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Cytokine, Inflammation and Pathogenesis

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Effector Mechanisms
Registered attendees can view abstracts starting on 04/10/2013

Arturo Zychlinsky, Max Planck Institute for Infection Biology, Germany
DNA Nets, a Potent Anti-Microbial Effector Function of Neutrophils

Speaker to be Announced

Jonathan Howard, University of Cologne, Germany
IFN-gamma-Inducible GTPases in Control of Intracellular Parasites

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


MONDAY, MAY 13

07:30—08:30
Breakfast

08:30—11:30
Innate Cytokines Influencing Adaptive Immunity and Inflammation
Registered attendees can view abstracts starting on 04/10/2013

* Richard M. Locksley, University of California, San Francisco, USA
Innate Determinants of Th2 Responses

Alan Sher, NIAID, National Institutes of Health, USA
Innate Regulation of Th1 Responses

Kingston H. G. Mills, Trinity College Dublin, Ireland
Innate Determinants of Th17 Responses

Edgar M. Carvalho, Universidade Federal da Bahia, Brazil
Innate Determinants of T Lymphocyte Responses in Human Leishmaniasis

Short Talk(s) Chosen from Abstracts

09:50—10:10
Coffee Break

09:50—10:10
Poster Setup

11:30—12:30
Lunch

12:00—14:30
Poster Session 3

14:30—16:30
Workshop 3: Cell Death and Pathogenesis

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Innate Signals in Disease Pathogenesis
Registered attendees can view abstracts starting on 04/10/2013

Speaker to be Announced

Douglas Golenbock, University of Massachusetts Medical School, USA
DNA Sensing Drives the Innate Immune Response in Malaria

* Anne O'Garra, MRC National Institute for Medical Research, UK
Cytokines and Pathogenesis in TB

Short Talk Chosen from Abstracts

19:00—
On Own for Dinner


TUESDAY, MAY 14

07:30—08:30
Breakfast

08:30—11:30
Cell Death in Host Resistance and Pathogenesis of Infectious Diseases
Registered attendees can view abstracts starting on 04/10/2013

Douglas R. Green, St. Jude Children's Research Hospital, USA
Pathogen-Induced Necrosis

Ricardo T. Gazzineli, CPQRR-Fiocruz, Brazil
Pyroptosis in Malaria

Speaker to be Announced

Maya Saleh, McGill University, Canada
Role of Caspases in the Regulation of Inflammation and Immunity

Short Talk(s) Chosen from Abstracts

09:50—10:10
Coffee Break

11:30—
On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—18:45
Immunological Adjuvants and Vaccines
Registered attendees can view abstracts starting on 04/10/2013

* Jorge Kalil, Universidade de São Paolo, Brazil
Dengue Vaccine Candidates

Robert L. Coffman, Dynavax Technologies, USA
Clinical Applications of Innate Immune Signals

Bali Pulendran, Emory University, USA
Long-Term Immune Responses Induced by Adjuvants

18:45—19:30
Closing Keynote Address
Registered attendees can view abstracts starting on 04/10/2013

Michel C. Nussenzweig, Rockefeller University, USA
Targeting Dendritic Cells in Malaria Vaccine

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


WEDNESDAY, MAY 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 May - 15 May 2013
Ouro Preto
Brazil
meeting website