Immunopathology of Type 1 Diabetes (Z1)

A great deal has been learned about the effectors and mechanisms of Type 1 diabetes from preclinical models and studies of samples from patients at risk and with the disease. However, despite this progress, translation of this understanding into new therapies that will have impact on patients has not been realized. The goal of this meeting is to review our understanding of the mechanisms that are involved in the disease with consideration of the ways in which this understanding has resulted in clinical translation and how it has failed. Our goal is to integrate the most up to date understanding of mechanisms of autoimmune diabetes with studies in patients in order to identify ways in which developments in preclinical studies can provide insight into the past experiences in clinical studies and improve the design of future studies. The meeting will explore the following areas in detail: 1) What are the genetic determinants, immunopathology, and triggers of the disease? 2) What are the immune effectors that lead to beta cell destruction – how do they form and what are their functional characteristics? 3) How are immune effectors controlled in healthy individuals and how does this control fail in T1DM? 4) What has been the experience in restoring immune tolerance in humans – how can this be improved in the future?
+ show speakers and program
URSDAY, APRIL 4

15:00—19:30
Arrival and Registration

MacDonald Foyer
18:15—19:15
Refreshments

MacDonald Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Luke A. J. O'Neill, Trinity College Dublin, Ireland
Innate Immunity, Inflammation and Autoimmunity

Diane J. Mathis, Harvard Medical School, USA
Control of Autoimmune Diabetes


FRIDAY, APRIL 5

07:00—08:00
Breakfast

Frontenac Ballroom and Foyer
08:00—11:15
Modulation of Immunity toward Autoimmune Therapy: From Mouse to Man (Joint)
Registered attendees can view abstracts starting on 03/04/2013

NOTE: The focus of this session is on the regulatory networks controlling immune response and the modulation of these processes towards amelioration of autoimmune disease.

MacDonald Ballroom
Dario A. A. Vignali, St. Jude Children's Research Hospital, USA
Molecular Control of Regulatory Networks in Autoimmunity

Jeffrey A. Bluestone, University of California, San Francisco, USA
Treg Plasticity and Function: Mechanisms and Therapeutic Implications

Richard A. Flavell, Yale University School of Medicine, USA
Humanized Mouse Models in the Study of Autoimmune Diseases

Stephen D. Miller, Northwestern University Medical School, USA
Induction of Immune Tolerance in the Treatment of Autoimmunity

Maria Grazia Roncarolo, San Raffaele Scientific Institute, Italy
Disregulation of Immune Response in Genetic and Acquired Autoimmune Diseases

Short Talk Chosen from Abstracts

09:20—09:40
Coffee Break

MacDonald Foyer
11:15—13:00
Poster Setup

Frontenac Ballroom and Foyer
13:00—22:00
Poster Viewing

Frontenac Ballroom and Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
Immune Effector/Autoantigens in T1DM
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Gerald T. Nepom, Benaroya Research Institute, USA
The T Cell Repertoire in Human Autoimmune Diabetes

Teresa P. DiLorenzo, Albert Einstein College of Medicine, USA
Antigen Specific T Cells in NOD Diabetes

Mark Peakman, King's College London, UK
Pathogenic T Cells in Human T1D

Short Talk Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

17:00—19:00
Mechanisms of Peripheral and Central Tolerance
Registered attendees can view abstracts starting on 03/04/2013

MacDonald ABC
John W. Kappler, National Jewish Health, USA
MHC Peptide Registers-MHC Complexity Beyond Peptide

* Kristin Tarbell, NIDDK, National Institutes of Health, USA
The Role of DCs for Antigen-Specific Tolerance Induction in the Context of Autoimmune Diabetes

Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical School, USA
Regulation of Dendritic Cell and T Cell Function by Nonhematopoietic Stroma

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Frontenac Ballroom and Foyer
19:30—22:00
Poster Session 1

Frontenac Ballroom and Foyer

SATURDAY, APRIL 6

07:00—08:00
Breakfast

Frontenac Ballroom and Foyer
08:00—11:15
Regulatory and Developmental Control of T1DM
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Mark Anderson, University of California, San Francisco, USA
Peripheral Tolerance-AIRE: What's New, What's Next?

Steven F. Ziegler, Benaroya Research Institute and University of Washington School of Medicine, USA
Transcriptional Control of Tregs

Pere Santamaria, University of Calgary, Canada
Maturation and Modulation of CD8+ T Effector Cells

Jane H. Buckner, Benaroya Research Institute at Virginia Mason, USA
T Cell Deregulation in Human T1DM

David A. Hafler, Yale School of Medicine, USA
Human Autoimmunity, a Common Genetic Disease(s)

Short Talk Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

08:00—11:00
Innate Immunity and Autoimmune Disease
Registered attendees can view abstracts starting on 03/04/2013

NOTE: Explores how innate immune cells play a role in the initiaition and progression of autoimmunity.

MacDonald ABC
* Silvia Bolland, NIAID, National Institutes of Health, USA
TLR7 and Autoimmunity

Virginia Pascual, Baylor Institute for Immunology Research, USA
pDCs and IFN Signature in SLE

Juan Rivera, NIAMS, National Institutes of Health, USA
Basophils in the Amplification of SLE

Melissa A. Brown, Northwestern University, USA
Mast Cells and Neutrophils in CNS Disease

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

MacDonald Foyer
11:15—13:00
Poster Setup

Frontenac Ballroom and Foyer
13:00—22:00
Poster Viewing

Frontenac Ballroom and Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
Workshop 1: Basic Research Advances

Frontenac Ballroom
Short Talks Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

17:00—19:00
Challenges and Lessons from Immunotherapy
Registered attendees can view abstracts starting on 03/04/2013

NOTE: This session explores how identification of biomarkers and new treatments are advancing our knowledge of mechanisms and the pathophysiology underlying autoimmune disease and explores the challenges faced in the development and use of therapies in autoimmunity

MacDonald ABC
* Timothy W. Behrens, Genentech, Inc., USA
Biomarkers for Clinical Trials and the Clinic - Where to Next?

Speaker to be Announced

Robert P. Anderson, ImmusanT, Inc., USA
Celiac Disease - Can We Transition from Peptides to Treatment?

Short Talk Chosen from Abstracts

17:00—19:00
Workshop 2: Translational/Clinical Research Advances

MacDonald DEF
Short Talks Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Frontenac Ballroom and Foyer
19:30—22:00
Poster Session 2

Frontenac Ballroom and Foyer

SUNDAY, APRIL 7

07:00—08:00
Breakfast

Frontenac Ballroom and Foyer
08:00—11:15
The Microflora in the Regulation of Immunity and Autoimmunity (Joint)
Registered attendees can view abstracts starting on 03/04/2013

NOTE: Reviews recent advance on the microbiomes influence in initiation, progression, and regulation of immune responses and autoimmune disease.

MacDonald Ballroom
Karen E. Nelson, J. Craig Venter Institute, USA
The Makeup of the Human Microbiome

Alexander Chervonsky, University of Chicago, USA
Microbial Influence on T1D

Fiona M. Powrie, University of Oxford - NDM, UK
Regulation of Colitis by the Gut Microbiome

Mark A. Atkinson, University of Florida, USA
The Gut Microbiome in Diabetes

Lloyd H. Kasper, Dartmouth Medical School, USA
Gut, Bugs and the Brain: The Role of Commensal Bacteria in CNS Demyelination

Short Talk Chosen from Abstracts

09:20—09:40
Coffee Break

MacDonald Foyer
11:00—13:00
Poster Setup

Frontenac Ballroom and Foyer
13:00—22:00
Poster Viewing

Frontenac Ballroom and Foyer

On Own for Lunch and Recreation


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

14:30—16:30
Workshop 1: Basic Mechanisms in Autoimmunity

MacDonald ABC
Short Talk(s) Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

14:30—16:30
Workshop 2: Clinical and Translational Aspects of Autoimmunity

MacDonald ABC
Short Talk(s) Chosen from Abstracts

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
Immune Modulation and Effects of Immune Modulators on T1DM
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Matthias G. von Herrath, La Jolla Institute for Allergy and Immunology, USA
Autoreactive CD8 Cells - How Do We Best Control Them to Treat T1D?

Lucienne Chatenoud, INSERM U1013, Hôpital Necker-Enfants Malades, France
Anti-CD3 Therapy

Bart O. Roep, Leiden University Medical Center, Netherlands
Methods and Mechanisms of Immune Modulation in Humans

Short Talk Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

17:00—19:00
Lymphocytes in Autoimmunity I - B Cells
Registered attendees can view abstracts starting on 03/04/2013

NOTE: Covers recent advances on B cells as promoters and regulators of immune responses and autoimmunity.

MacDonald ABC
Eric Meffre, Yale University School of Medicine, USA
Autoreactive B Cells - Who, What, Where?

Andreas Radbruch, Deutsches Rheuma-Forschungszentrum, Berlin, Germany
Plasmablasts versus Plasma Cells - Roles in Autoantibody Production

Thomas F. Tedder, Duke University Medical Center, USA
B Cell Regulation of Immune Responses

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Frontenac Ballroom and Foyer
19:30—22:00
Poster Session 3

Frontenac Ballroom and Foyer

MONDAY, APRIL 8

07:00—08:00
Breakfast

Frontenac Ballroom and Foyer
08:00—11:15
Cellular and Environmental Networks in T1DM
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Li Wen, Yale University, USA
Role of TLRs in Regulation of Autoimmunity and beta Cells in Type 1 Diabetes

Anne Cooke, University of Cambridge, UK
Th17 Cells in T1DM

Agnès C. Lehuen, Hôpital Saint Vincent de Paul, France
Viral Infections and NKT Cells in Type 1 Diabetes

David V. Serreze, The Jackson Laboratory, USA
To Be or Not to Be: Challenges in B-lymphocyte Directed Interventions for Type 1 Diabetes

George S. Eisenbarth, University of Colorado Health Sciences Center, USA
Autoantigen Presentation in Type 1 Diabetes: Opportunity for Antigen-Specific Interventions?

Short Talk Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

08:00—11:00
Lymphocytes in Autoimmunity II - T Cells
Registered attendees can view abstracts starting on 03/04/2013

NOTE: Discussion of T cell function in immunity and autoimmunity with emphasis on human immunology.

MacDonald ABC
Federica Sallusto, Institute for Research in Biomedicine, Switzerland
T Cell Subsets in Human Disease

Shigeo Koyasu, Keio University School of Medicine, Japan
Natural Helper Cells in Th2-type Innate Immunity

Carola G. Vinuesa, Australian National University, Australia
T Follicular Helper Cells during Immunity and Tolerance

Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School, USA
Th17 Cells in Tissue Inflammation and Autoimmunity

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

MacDonald Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

MacDonald Foyer
17:00—19:00
The Future of T1DM Research and Clinical Translation
Registered attendees can view abstracts starting on 03/04/2013

MacDonald DEF
Linda S. Wicker, University of Cambridge, UK
IL-2 Therapy for Type 1 Diabetes

Kevan C. Herold, Yale University, USA
Combination Therapies for Type 1 Diabetes

Megan K. Levings, University of British Columbia, Canada
Regulatory T Cell Therapy in Autoimmunity and Transplantation

Short Talk Chosen from Abstracts


Following Session is for Advances in the Knowledge and Treatment of Autoimmunity (Z2)

17:00—19:00
Systems Approaches to Autoimmunity
Registered attendees can view abstracts starting on 03/04/2013

NOTE: What information is being gained by a systems approach toward the study of autoimmunity and how can we best utilize these vast data sets?

MacDonald ABC
Speaker to be Announced

Edward K. Wakeland, University of Texas Southwestern Medical Center, USA
Genomic Analysis of Systemic Autoimmunity

Atul J. Butte, Stanford University, USA
Personalized and Systems Medicine

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Frontenac Ballrm and Foyer
20:00—23:00
Entertainment

Frontenac Ballrm and Foyer

TUESDAY, APRIL 9


Departure


*Session Chair †Speaker invited, not yet responded.

4 Apr - 9 Apr 2013
Whistler
Canada
meeting website