Nuclear Receptors and Friends: Roles in Energy Homeostasis and Metabolic Dysfunction

Regulatory mechanisms that maintain energy homeostasis are vital to metabolic health. While short-term adaptation to energy balance challenges relies heavily on post-translational modifications, long-term adaptive responses require transcriptional networks that sense energy-state and metabolic stressors and execute gene expression programs in a signal- and context-dependent manner. Such transcriptional networks can determine pathways controlling energy balance, physiological responses to changes in energy state, and the development of pathophysiological states that manifest as metabolic disease. Elucidation of the transcriptional networks and the underlying regulatory mechanisms can facilitate therapeutic approaches aiming at altering energy balance, e.g. by increasing energy expenditure, or ameliorating the complications arising from states of excess positive energy balance, e.g. hepatic steatosis, T2 diabetes, and cardiovascular disease. Nuclear receptors (NRs), a family of ligand-dependent transcription factors that sense hormones, dietary lipids, and vitamins, co-operate with NR cofactors to regulate diverse aspects of metabolism. The meeting will weave the roles of NRs and NR cofactors with the roles of other types of transcription factors that carry important functions in integrating signal- and context-dependent information and enabling appropriate adaptive metabolic responses. Our goal is to bring together junior and senior investigators that study transcriptional mechanisms controlling different aspects of energy homeostasis and metabolic adaptation, and thereby stimulate new ideas on how transcriptional networks could be targeted therapeutically in the context of metabolic disease.
+ show speakers and program
WEDNESDAY, APRIL 3

16:00—20:00
Arrival and Registration


THURSDAY, APRIL 4

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 03/03/2013

Helen H. Hobbs, University of Texas Southwestern Medical Center, USA
Role of ABC Transporters in Lipid Transport

09:00—12:00
Nuclear Receptors and Metabolism: Liver and Gut Pathways
Registered attendees can view abstracts starting on 03/03/2013

Antonio Moschetta, Consorzio Mario Negri Sud, Italy
Regulation of Enterocyte Aging via PGC1

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
Nuclear Receptor/FGF Endocrine Signaling and Metabolism

David D. Moore, Baylor College of Medicine, USA
LRH1, the Gut and the Liver

Michela Plateroti, Université Claude Bernard Lyon 1, France
Thyroid Receptor and Intestinal Stemness

09:40—10:00
Coffee Break

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Nuclear Receptors and Control of Food Intake
Registered attendees can view abstracts starting on 03/03/2013

Miguel López, Universidad de Santiago de Compostela, Spain
Oestrogen Receptors and Energy Balance

Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
SF1 in VMN and Energy Balance

Tony K.T. Lam, University of Toronto, Canada
Nutrient and Hypothalamus Sensing

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, APRIL 5

07:00—08:00
Breakfast

08:00—11:00
Nuclear Receptors and Energy Expenditure Pathways
Registered attendees can view abstracts starting on 03/03/2013

Anastasia Kralli, The Scripps Research Institute, USA
The Role of The PGC-1/ERR Network In Mitochondrial Function and BAT Physiology

Antonio J. Vidal-Puig, University of Cambridge, UK
Brown Fat Activity Sensitizers

Krishna Chatterjee, University of Cambridge, UK
Nuclear Receptors and Metabolic Dysfunction: Insights from Human Genetics

Beatrice Desvergne, University of Lausanne, Switzerland
Too Much or Too Little Fat: Same Metabolic Consequences, Same Mechanisms?

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop and Round-Table Discussion: Targeting NRs for the Treatment of Metabolic Disease

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Adipogenesis and Energy Storage
Registered attendees can view abstracts starting on 03/03/2013

Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University, USA
Systems Approaches to Adipogenesis

Juro Sakai, University of Tokyo, Japan
Epigenomic Regulation of Inflammation, Energy Metabolism and Adipogenesis

Lluis Fajas, INSERM, France
Cell Cycle and Energy Homeostasis

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, APRIL 6

07:00—08:00
Breakfast

08:00—11:00
Lipid Metabolic Sensors
Registered attendees can view abstracts starting on 03/03/2013

Peter Tontonoz, University of California, Los Angeles, USA
Idolizing the LDL Receptor

Karen Reue, University of California, Los Angeles, USA
Lipin Proteins and Cellular Lipid Homeostasis

David Shapiro, Intercept Pharmaceuticals Inc., USA
FXR Agonism - From Theory to Practice

Carl S. Thummel, University of Utah School of Medicine, USA
Lipid Metabolism in Flies

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Immune System and Metabolism
Registered attendees can view abstracts starting on 03/03/2013

Mercedes Ricote, Centro Nacional de Investigaciones Cardiovasculares, Spain
Emerging Roles of RXRs in Macrophage Biology

Ajay Chawla, University of California, San Francisco, USA
Innate Immunity and Metabolism

Inez Rogatsky, Weill Medical College of Cornell University, USA
A Transcriptional Coregulator GRIP1 at the Intersection of Pro- and Anti-Inflammatory Pathways

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, APRIL 7

07:00—08:00
Breakfast

08:00—11:00
Skeletal Muscle, Exercise and Diet
Registered attendees can view abstracts starting on 03/03/2013

Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Nuclear Receptor - miRNA Regulatory Networks

Juleen R. Zierath, Karolinska Institutet, Sweden
Epigenetic Regulation in Response to Exercise

Ronald M. Evans, The Salk Institute, USA
PPARs, ERRs, Muscle

Vincent Giguère, McGill University, Canada
Estrogen-Related Receptors and Control of Energy Metabolic Pathways

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Circadian Clock and Metabolism
Registered attendees can view abstracts starting on 03/03/2013

Katja A. Lamia, The Scripps Research Institute, USA
Cryptochromes Are NR Co-Repressors

Thomas P. Burris, The Scripps Research Institute, USA
ROR and REV-ERB Regulation of Immune Function and Metabolism

Paolo Sassone-Corsi, University of California, Irvine, USA
Metabolism Control of the Circadian Clock

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


MONDAY, APRIL 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Apr - 8 Apr 2013
Alpbach
Austria
meeting website