Immune Activation in HIV Infection: Basic Mechanisms and Clinical Implications

One major hallmark of HIV infection is chronic immune activation that promotes viral replication and drives CD4+ T cell depletion. The mechanisms leading to Immune activation are not well understood, and strategies to dampen it are urgently needed. Immune activation in HIV infection can stem from foreign antigen stimulation, including HIV, microbial products and co-infections as well as compensatory homeostatic mechanisms. Continuous immune stimulation most likely creates a permissive environment for further viral replication, while temporarily allowing successful replenishment of the T-cell pool. Type I interferon, microbial translocation, activated (but ineffective) effector T cells, dysfunctional regulatory T cells and inadequate T helper 17 cells have all been suggested to play important roles in the cycle of activation, functional exhaustion and T-cell death that leads to immunodeficiency. In treated HIV infection, chronic immune activation persists and is implicated in non-infectious clinical complications of HIV that account for most of the morbidity and mortality in patients treated with anti-retroviral therapy. The goal of the meeting will be to update the participants on the new insights of mechanisms of immune activation and its deleterious effects on HIV infection from transmission to chronic treated infection, and how this knowledge could potentially translate to treatment interventions. Our vision is to bring together basic science (even beyond HIV), immunology, virology and clinical science into each session with the hope that participants will interact and be inspired for collaborative translational projects.
+ show speakers and program
WEDNESDAY, APRIL 3

15:00—19:30
Arrival and Registration

Foyer
18:15—19:15
Refreshments

19:15—21:00
Welcome and Keynote Session
Registered attendees can view abstracts starting on 03/03/2013

Mary Carrington, Frederick National Laboratory for Cancer Research, USA
The Influence of Immunogenetic Variation on HIV Disease

Michael M. Lederman, Case Western Reserve University, USA
Immune Activation in HIV: It's Not Just the Virus, or Is It?


THURSDAY, APRIL 4

07:00—08:00
Breakfast

Summit Gallery
08:00—12:00
Molecular and Cellular Biology of Immune Activation
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Charles R. Mackay, Monash University, Australia
Diet and Gut Microbiota in the Regulation of Immunity and Gut Epithelial Permeability

Susan Moir, NIAID, National Institutes of Health, USA
B Cells in HIV Pathogenesis

George Kassiotis, National Institute for Medical Research, UK
Mechanisms of Lymphocyte Activation and T Cell-Mediated Pathology in Mice Infected by Retroviruses

Frank Kirchhoff, University of Ulm, Germany
Possible Role of Viral Properties in HIV-Induced Immune Activation

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Foyer
12:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom

On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Therapeutic Targets of IA

Colorado Ballroom
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Foyer
17:00—19:00
HIV Transmission and Acute Infection
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Thomas J. Hope, Northwestern University, Feinberg School of Medicine, USA
Imaging of Viral Dissemination in Cervical Mucus and Role of Ab

Gabriella Scarlatti, San Raffaele Scientific Institute, Italy
Early Events of Transmission at the Intestinal Mucosal and Role of Dendritic Cells

Michaela Müller-Trutwin, Institut Pasteur, France
Innate Immune Responses in the Acute Phase of Non-Pathogenic SIVagm Infection

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 1

Breckenridge Ballroom

FRIDAY, APRIL 5

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Viral Reservoirs and Immune Dysfunction
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Michael H. Malim, King's College London School of Medicine, UK
HIV and Innate Anti-Viral Factors

Monsef Benkirane, Institut de Genetique Humaine, France
Regulation of Cellular Factors Involved in HIV Virus Gene Expression

Damian F.J. Purcell, University of Melbourne, Australia
Mechanisms Taking Virus from Latency to T-Cell Activation

Una O'Doherty, University of Pennsylvania Medical Center, USA
Important Differences between HIV Infection of Resting versus Activated T Cells

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Mucosal Immunity and HIV
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Mirko Paiardini, Emory University, YNPRC, USA
Homeostasis of CD4+ T Cell Subsets in SIV Infection

Jacob D. Estes, NCI, National Institutes of Health, USA
GI Damage and Immune Activation in SIV

Frederic D. Bushman, University of Pennsylvania School of Medicine, USA
Deep Sequence of the Microbiome in HIV

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 2

Breckenridge Ballroom

SATURDAY, APRIL 6

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Immune Activation and Co-Infections
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Nina Bhardwaj, New York University School of Medicine, USA
Role of Dendritic Cells and Type I Interferons in HIV Pathogenesis and Immune Activation

Michael L. Dustin, New York University School of Medicine, USA
Imaging of Immune Synapses, Kinapses versus Synapses, and Role in Inflammation

Martyn French, University of Western Australia, Australia
Immune Reconstitution Inflammatory Syndrome in HIV Infection

Richard A. Koup, NIAID, National Institutes of Health, USA
Role of Co-Pathogens in HIV Immune Dysfunction

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Foyer
11:00—13:00
Poster Setup

Breckenridge Ballroom
13:00—22:00
Poster Viewing

Breckenridge Ballroom

On Own for Lunch and Recreation

14:30—16:30
Workshop 2: HIV and Aging

Colorado Ballroom
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Viral and Host Genes and Genomics
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Nabila Seddiki, Vaccine Research Institute and Université Paris-Est Créteil (UPEC), France
Role of Treg in HIV Pathogenesis

Javier Martinez-Picado, ICREA and irsiCaixa Foundation, Spain
HIV Persistence and Immune Activation

Philip Tarr, University of Basel, Switzerland
Genetic Associations of Non-Infectious Complications of HIV

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Breckenridge Ballroom
19:30—22:00
Poster Session 3

Breckenridge Ballroom

SUNDAY, APRIL 7

07:00—08:00
Breakfast

Summit Gallery
08:00—11:00
Viral and Cellular Aspects of Immune Activation and Aging under Antiretroviral Therapy
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Alan J. Korman, Bristol-Myers Squibb, USA
Immunostimulatory Monoclonal Ab to Reverse Immunosuppression

Irini Sereti, NIAID, National Institutes of Health, USA
Biomarkers in HIV Infection

Ivona Pandrea, University of Pittsburgh, USA
Lessons from Non-Human Primate Models

Joel Nee-lartey Blankson†, Johns Hopkins School of Medicine, USA
Reservoirs and Eradication

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Foyer
17:00—19:00
Future Directions in Immune Interventions
Registered attendees can view abstracts starting on 03/03/2013

Colorado Ballroom
Sharon R. Lewin, Alfred Hospital and Monash University, Australia
Bench to Bedside: Where Do We Go from Here?

Mauro Schechter, Universidade Federal do Rio de Janeiro, Brazil
Preventive Efforts, New Directions Beyond Vaccines

Steven G. Deeks, University of California, San Francisco, USA
HIV and Aging: Novel Therapeutic Approaches

19:00—20:00
Social Hour w/ Lite Bites

Breckenridge Ballroom
20:00—23:00
Entertainment

Breckenridge Ballroom

MONDAY, APRIL 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Apr - 8 Apr 2013
Breckenridge
United States of America
meeting website