Keystone Symposia: Molecular Clockworks and the Regulation of Cardio-Metabolic Function

Several discoveries point to the importance of the molecular clockworks as an integrative system in biology. The molecular clock is highly conserved and remarkably robust in resisting disruption; it is highly regulated and is placed centrally amongst biological networks that communicate between tissues. In recent years it has become apparent that peripheral clocks, widely distributed, retain the capacity for independence as well as operating under the direction of the master clock in the supracharismatic nucleus (SCN). Indeed, evidence has begun to emerge that peripheral clocks talk to each other and back to the SCN. As we begin to understand the impact of major environmental influences, such as food restriction and fluctuations in body temperature, on clock integration and behavior, so we will begin to elucidate the roles of fine adjusters, such as hormones, physical forces and nutritional ingredients, all of which can impact asymmetrically individual peripheral clocks and potentially signal between them. Much remains to be learned about the multiple levels of regulation of clockworks at the transcriptional, translational, post translational and epigenomic levels, information that lends itself to systems wide analysis. Indeed, increasing insight into the systems biology of the molecular clock promises to rationalize selection of drug targets whereby we might modulate clock function. High throughput screens have already yielded novel approaches to regulating the phase and amplitude of molecular clocks. Evocation of clock dependent phenotypes in humans has come of age with recognition that the oscillatory nature of the metabolome and the ability to track gene oscillations in several tissues ex vivo will complement increasingly sophisticated approaches to segregating endogenous rhythms from tracking time dependent changes in tissue function in humans. Experiments in a range of model systems have pointed to the importance of the molecular clock in carbohydrate and lipid metabolism, cardiovascular function and aging. This program will assemble investigators who work in multiple model systems, including humans, to share information on the ways in which the molecular clock is regulated, how its systems are integrated and how that knowledge might be harvested to enhance our understanding of human physiology and to yield novel treatments for human disease.
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WEDNESDAY, APRIL 3 16:0020:00 Arrival and Registration Ballroom Lobby THURSDAY, APRIL 4 07:0008:00 Breakfast Superior/Superior Lobby 08:0009:00 Welcome and Keynote Address Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Eric Schadt, Pacific Biosciences/Mount Sinai School of Medicine, USA Systems Integration by the Molecular Clock 09:0011:15 Clockworks I Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Joseph S. Takahashi, HHMI/University of Texas Southwestern Medical Center, USA The Molecular Clock John Hogenesch, University of Pennsylvania School of Medicine, USA Systems Biology of the Molecular Clock Michael M. Rosbash, Brandeis University, USA Regulation of Clock Function in Drosophila 09:4010:00 Coffee Break Ballroom Lobby 11:1513:00 Poster Setup Ballroom 1 13:0022:00 Poster Viewing Ballroom 1 On Own for Lunch and Recreation 16:3017:00 Coffee Available Ballroom Lobby 17:0019:00 Clockworks II Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Ueli Schibler, University of Geneva, Switzerland Signaling to Peripheral Clocks Felix Naef, EPFL, Switzerland Genome-Wide Regulation of the Mammalian Metabolic Clock Martha Merrow, University of Groningen, Netherlands A Molecular Clock in Yeast 19:0020:00 Social Hour w/ Lite Bites Ballroom 1 19:3022:00 Poster Session 1 Ballroom 1 FRIDAY, APRIL 5 07:0008:00 Breakfast Superior/Superior Lobby 08:0011:00 Cardio-Metabolic I Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Speakers to be Announced Hitoshi Okamura, Kyoto University Clock Gene, Aldosterone and Hypertension Carla B. Green, University of Texas Southwestern Medical Center, USA Circadian Post-Transcriptional Regulation of Metabolic Pathways 09:2009:40 Coffee Break Ballroom Lobby 11:0013:00 Poster Setup Ballroom 1 13:0022:00 Poster Viewing Ballroom 1 On Own for Lunch and Recreation 16:3017:00 Coffee Available Ballroom Lobby 17:0019:00 Clockworks III Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Erin K. O'Shea, Harvard University, USA Timekeeping with a Three-Protein Circadian Clock Akhilesh Basi Reddy, University of Cambridge, UK Clockworks outside the Nucleus Speaker to be Announced 19:0020:00 Social Hour w/ Lite Bites Ballroom 1 19:3022:00 Poster Session 2 Ballroom 1 SATURDAY, APRIL 6 07:0008:00 Breakfast Superior/Superior Lobby 08:0011:00 Cardio-Metabolic II Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 R. Daniel Rudic, Georgia Health Sciences University, USA The Vascular Biology of the Molecular Clock Speakers to be Announced Frank A.J.L. Scheer, Harvard Medical School, USA Endogenous Biological Rhythms of Cardiovascular Function in Humans 09:2009:40 Coffee Break Ballroom Lobby On Own for Lunch and Recreation 16:3017:00 Coffee Available Ballroom Lobby 17:0019:00 Cardio-Metabolic III Registered attendees can view abstracts starting on 03/03/2013 Ballroom 2-3 Joseph T. Bass, Northwestern University, USA Metabolic Consequences of Clock Dysfunction Amita Sehgal, University of Pennsylvania, USA Central and Metabolic Impacts of Clock Function in Drosophila Garret A. FitzGerald, University of Pennsylvania, USA Cardiometabolic Implications of Peripheral Clocks 19:0020:00 Social Hour w/ Lite Bites Ballroom 1-2 20:0023:00 Entertainment Ballroom 1-2 SUNDAY, APRIL 7 Departure

3 Apr - 7 Apr 2013
Snowbird
United States of America
meeting website