Epigenetic Marks and Cancer Drugs

The regulation of transcription by RNA polymerase II is the key controlling step in development, and its misregulation results in the pathogenesis of a number of human diseases including cancer. Several factors including the transcriptional initiation and elongation machineries, chromatin remodeling complexes, and chromatin modifiers have been shown to be central in the regulation of gene expression. Much has been learned about the molecular role of chromatin remodelers and modifiers in transcriptional control and human health. Most of such studies find their origination in the first discovery of histone deacetylase (HDAC) and its inhibitor trichostatin A (TSA). To date, other small molecular inhibitors of chromatin modifiers and interactors have been identified and some are being used successfully in clinic. The overall goal of this meeting is to gather experts in the area of genetics and biochemistry of chromatin and transcriptional regulators and further discuss how this process is involved in development and how small molecule inhibitors of transcription and chromatin modifiers can be used for the treatment of human diseases including cancer.
+ show speakers and program
WEDNESDAY, MARCH 20

16:00—20:00
Arrival and Registration

Zia Concourse

THURSDAY, MARCH 21

07:00—08:00
Breakfast

Eldorado Court
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
Stuart L. Schreiber, Harvard University, USA
Linking Genetic Features of Human Cancers and Histone-Modifying Enzymes for Future Cancer Therapies

09:00—11:15
Chromosomes, Chromatin and Transcription I
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* Shelley L. Berger, University of Pennsylvania, USA

B. Franklin Pugh, Pennsylvania State University, USA
Nucleosomal Positioning and the Regulation of Gene Expression

Patrick Cramer, University of Munich (LMU), Germany
Structural Insight into the Transcribing RNA Polymerase II

Anne Brunet, Stanford University, USA
Epigenetic Regulation of Aging

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

Zia Concourse
11:15—13:00
Poster Setup

Sunset Room/Eldorado Court
13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Chromosomes, Chromatin and Transcription II
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* Ali Shilatifard, Stowers Institute for Medical Research, USA

C. David Allis, Rockefeller University, USA
Beyond the Double Helix: Varying the 'Histone Code'

Richard A. Young, Whitehead Institute for Biomedical Research, USA
Connecting Transcription, Chromatin and Cancer

Bradley R. Cairns, University of Utah, USA
Chromatin Architecture in Gene Expression and Epigenetics

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
RNAi-Dependent Formation of Heterochromatin

19:00—20:00
Social Hour w/ Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 1

Sunset Room/Eldorado Court

FRIDAY, MARCH 22

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Polycomb and Trithorax in Gene Expression and Cancer
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* B. Franklin Pugh, Pennsylvania State University, USA

Ali Shilatifard, Stowers Institute for Medical Research, USA
Active Chromatin Marks and Human Cancer

Danny F. Reinberg, HHMI/New York University, USA
Repressive Chromatin Marks in Epigenetics and Cancer

Jürg Müller, Max Planck Institute of Biochemistry, Germany
Polycomb Family in Transcriptional Repression and Development

Peter Verrijzer, Erasmus University Medical Center, Netherlands
Polycomb Family of Transcriptional Regulators in Development

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room/Eldorado Court
13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Histone Marks in Development and Cancer
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* Ramin Shiekhattar, Wistar Institute, USA

Thomas Jenuwein, Max Planck Institute of Immunobiology and Epigenetics, Germany
Talk Title to be Determined

Tony Kouzarides, University of Cambridge, UK
Histone Acetylation, Brd4 and Human Leukemia

Alexander (Sasha) Tarakhovsky, Rockefeller University, USA
Ezh2, Histone Methylation and Prostate Cancer

Shelley L. Berger, University of Pennsylvania, USA
Chromatin, Aging and Cancer

19:00—20:00
Social Hour w/ Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 2

Sunset Room/Eldorado Court

SATURDAY, MARCH 23

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
DNA Methylation in Development and Cancer
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
Yi Zhang, University of North Carolina at Chapel Hill, USA
DNA Demethylation and Epigenetics

Peter A. Jones, University of Southern California, USA
DNA Methylation and Cancer Therapy

Jean-Pierre Issa, Temple University School of Medicine, USA
Epigenetic Therapy from Bedside to Bench

Short Talks Chosen from Abstracts

09:20—09:40
Coffee Break

Zia Concourse
11:00—13:00
Poster Setup

Sunset Room/Eldorado Court
13:00—22:00
Poster Viewing

Sunset Room/Eldorado Court

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Enhancers and ncRNAs in Development and Cancer
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
Ramin Shiekhattar, Wistar Institute, USA
Long Noncoding RNAs, and Enhancer and Gene Expression

Jeannie T. Lee, Massachusetts General Hospital, USA
Long Noncoding RNAs in Development

Robert Martienssen, Cold Spring Harbor Laboratory, USA
Talk Title to be Determined

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Eldorado Court/Sunset Room
19:30—22:00
Poster Session 3

Sunset Room/Eldorado Court

SUNDAY, MARCH 24

07:00—08:00
Breakfast

Eldorado Court
08:00—11:00
Myc, Transcriptional Regulation and Development
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA
Regulation of Cell Function through the Myc Network

Michael D. Cole, Dartmouth Medical School, USA
An Epigenetic Model for Myc-Mediated Repression

Bruno Amati, Italian Institute of Technology, Italy
Epigenome Regulation in Myc-Driven Tumors

James E. Bradner, Dana-Farber Cancer Institute, USA
BET Bromodomain Inhibitors Targeting c-Myc

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Zia Concourse

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Zia Concourse
17:00—19:00
Transcription, Chromatin and Epigenetics in Cancer Therapy
Registered attendees can view abstracts starting on 02/20/2013

Anasazi Ballroom
* Robert N. Eisenman, Fred Hutchinson Cancer Research Center, USA

Laurie A. Boyer, Massachusetts Institute of Technology, USA
Noncoding Elements and Cell Fate

Robert Gould, Epizyme, Inc., USA
Drugging the Human Methylome: Discovery and Characterization of Inhibitors of Protein Methyltransferases for the Treatment of Genetically Defined Cancers

Patrick Trojer, Constellation Pharmaceuticals, USA
Targeting Histone Lysine Methylation in Cancer

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Eldorado Court/Sunset Room
20:00—23:00
Entertainment

Eldorado Court/Sunset Room

MONDAY, MARCH 25


Departure


*Session Chair †Speaker invited, not yet responded.

20 Mar - 25 Mar 2013
Santa Fe
United States of America
meeting website