RNA Silencing

RNA silencing systems are now well established as key components of regulation and control in many eukaryotes including animals and plants. The first flush of discoveries was focused around post-transcriptional regulation. It was anticipated that the small RNA specificity determinants of these silencing systems could be negative switches acting alongside transcription factors control of gene expression during growth, development and responses to external stimuli. More recently the emphasis has shifted. In terms of post-transcriptional regulation, it is now recognized that there are only a few examples in plants and worms in which sRNAs are simple switches. These RNAs are now seen as modulators or fine tuners of post-transcriptional regulation that are often components of negative feedback loops or of control networks in which there are long RNA negative regulators of the sRNAs and secondary sRNAs. The sRNAs can be transported or secreted out of cells and so the RNA mediated control networks may extend beyond one cell. The anticipated potential of sRNA therapeutics has yet to be delivered but they are proving to be a powerful diagnostic tool in cancer and other diseases. A second emerging area is in the link between sRNAs and epigenetic regulation. This link was revealed first from plant work but it is now known in animals in connection with piwi-associated RNAs or piRNAs. These epigenetic sRNAs and piRNAs are certainly important in defense against transposable elements but it is possible that they also influence genetic or epigenetic regulation in other cell types. In this complex array of sRNA functions, growing interest is now devoted also to the crucial role of long noncoding RNAs in processes of gene expression control both at the transcriptional and post-transcriptional levels. The 2013 Keystone Symposia meeting on RNA Silencing will focus on these emerging topics of network control systems and epigenetic regulation by various types of sRNA. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on RNA silencing in general provides an umbrella under which speakers from different areas of research (e.g., transcriptional regulation, cancer biology, development, epigenetics and virology) are being brought together in an environment that is highly conducive to cross-talk. Emphasis has also be placed on showcasing early stage investigators presenting on the program with a view to promoting the next generation of scientists in the RNA silencing field.
+ show speakers and program
TUESDAY, MARCH 19

16:00—20:00
Arrival and Registration


WEDNESDAY, MARCH 20

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/19/2013

Gary B. Ruvkun, Massachusetts General Hospital, Harvard Medical School, USA

09:00—12:00
Posttranscriptional RNA Silencing Pathways in Diverse Organisms
Registered attendees can view abstracts starting on 02/19/2013

Elisa Izaurralde, Max Planck Institute for Developmental Biology, Germany
Mechanisms of miRNA-Mediated Gene Silencing

A. Harel-Bellan, CEA, France
siRNA and Splicing

Craig P. Hunter, Harvard University, USA
Mobile sRNA in C. elegans

Olivier Voinnet, Swiss Federal Institute of Technology Zurich, Switzerland
RNA Silencing Pathways in Plants

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
piRNAs and RNA-Mediated Epigenetic Modification I
Registered attendees can view abstracts starting on 02/19/2013

Phillip D. Zamore, University of Massachusetts Medical School, USA
What Fruit Flies Teach Us About RNA Silencing

Haifan Lin, Yale University, USA
Cell Biology - Suppression of Phenotypic Variation

René F. Ketting, Hubrecht Institute, Netherlands
piRNAs Zebrafish

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


THURSDAY, MARCH 21

07:00—08:00
Breakfast

08:00—11:00
piRNAs and RNA-Mediated Epigenetic Modification II
Registered attendees can view abstracts starting on 02/19/2013

Eric A. Miska, University of Cambridge, UK
Small RNA and Transgenerational Effects in Worms

David C. Baulcombe, University of Cambridge, UK
Mobile RNA and Epigenetics in Plants

Nicholas J. Proudfoot, University of Oxford, UK
RNA and Epigenetic Modification in Mammals

Steven E. Jacobsen, HHMI/University of California, Los Angeles, USA
Plants and Epigenetic Mechanisms

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Long ncRNA
Registered attendees can view abstracts starting on 02/19/2013

John L. Rinn, Harvard University, USA
Linking RNA to Human Health and Disease

Gordon Simpson, University of Dundee, UK
Long Noncoding RNA in Plants

Speaker to be Announced

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


FRIDAY, MARCH 22

07:00—08:00
Breakfast

08:00—11:00
ncRNA in Development and Disease I
Registered attendees can view abstracts starting on 02/19/2013

Speaker to be Announced

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center/Harvard Medical School, USA
ceRNA Hypothesis

Irene Bozzoni, University La Sapienza, Rome, Italy
Role of Noncoding RNAs in Muscle Differentiation and in Neuromuscular Disorders

Xavier Estivill, Center for Genomic Regulation and University Pompeu Fabra, Spain
Neurodegenerative Disease

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
ncRNA in Development and Disease II
Registered attendees can view abstracts starting on 02/19/2013

Speaker to be Announced

Speaker to be Announced

Klaus Pantel, Universitätsklinikum Hamburg-Eppendorf, Germany
Circulating MicroRNAs as Biomarkers in Cancer Patients

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


SATURDAY, MARCH 23

07:00—08:00
Breakfast

08:00—11:00
ncRNA in Development and Disease III
Registered attendees can view abstracts starting on 02/19/2013

Valerio Orlando, Dulbecco Telethon Institute at IRCCS Santa Lucia, Italy
Dicer and Transcription Mechanisms

Lin He, University of California, Berkeley, USA
miRNAs at the Crossroad between Cancer and Reprogramming

Jørgen Kjems, University of Aarhus, Denmark
miRNA Sponges in Human Diseases

Reuven Agami, Netherlands Cancer Institute, Netherlands
miRNA Regulation by RNA-Binding Proteins and Cancer

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
RNA Silencing in Virus Disease
Registered attendees can view abstracts starting on 02/19/2013

Shou-Wei Ding, University of California, Riverside, USA
Induction and Suppression of RNA Silencing during Virus Infection

Bryan R. Cullen, Duke University Medical Center, USA
Viruses and microRNAs

John J. Rossi, Beckman Research Institute of the City of Hope, USA
Small Noncoding RNA Therapies for HIV-1

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


SUNDAY, MARCH 24


Departure


*Session Chair †Speaker invited, not yet responded.

19 Mar - 24 Mar 2013
Whistler
Canada
meeting website