Tuberculosis: Understanding the Enemy

Despite more than a century of research, tuberculosis (TB) remains one of the leading causes of death in the world. Although drug therapy is available, it remains cumbersome and difficult to administer in areas of the developing world where TB is most prevalent. Moreover, the rise of HIV and consequent marked increase in TB susceptibility and the increasing appearance of drug resistant bacterial strains has made management of infection far more difficult. New approaches to treatment and prevention could have an enormous impact on the disease. This meeting will bring together different disciplines, including microbial genomics and genetics, bacterial physiology, systems biology and drug development, to explore how Mycobacterium tuberculosis is transmitted and causes disease. In addition, the conference will be paired with a concurrent meeting that explores host responses to TB. Together, these two conferences will cover a breadth of TB biology and examine the interface between the host and pathogen. The conference will provide an opportunity for interactions among those from different fields and include many participants from disciplines that would not ordinarily participate in a meeting devoted exclusively to TB. We hope to stimulate new collaborations and introduce novel areas of biology so that the field will be positioned to tackle the many remaining challenges for combating this disease. The meeting will also provide an opportunity to develop and engage the next generation of researchers in the field by including junior and early stage investigators in the meeting format.




This meeting is part of the Keystone Symposia Global Health Series.

Global Health Travel Award Deadline: October 16, 2012
+ show speakers and program
WEDNESDAY, MARCH 13

16:00—20:00
Arrival and Registration


THURSDAY, MARCH 14

07:00—08:00
Breakfast


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
How Do Innate Cells Respond to Mtb (I)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: How does the lung respond to infection and ?how do the phagocyte and bacteria interact?

Larry S. Schlesinger, Ohio State University, USA
Early Lung Responses

Jennifer Philips, New York University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation

Helen A. Fletcher, University of Oxford, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG

Short Talks Chosen from Abstracts

08:00—11:00
Mycobacterium tuberculosis – From Single Cells to Systems
Registered attendees can view abstracts starting on 02/13/2013

John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
Single Cell Division Cycle Dynamics and Stress Responses

Veronique Anne Dartois, Public Health Research Institute, USA
Pharmacology, from Single Cells to Organisms

Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth

Short Talks Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

15:30—16:00
Coffee Available

16:00—17:00
Keynote Address: TB: The Continuing Challenge (Joint)
Registered attendees can view abstracts starting on 02/13/2013

Chris Dye, World Health Organization, Switzerland
Population Dynamics and Control of Tuberculosis

17:00—19:00
How do Innate Cells Respond to Mtb? (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease?

Carl F. Nathan, Weill Cornell Medical College, USA
Mtb Needs a Strong Host Immune Response—But Not Too Strong: Mechanisms of Mycobacterial Immunomodulation

Anne O'Garra, MRC National Institute for Medical Research, UK
Immune Responses in Tuberculosis: From Mouse Models to Human Disease

David G. Russell, Cornell University, USA
Intracellular Survival by Mycobacterium: No Pressure!

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 15

07:00—08:00
Breakfast


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradigm?
Registered attendees can view abstracts starting on 02/13/2013

NOTE: While antigen-specific CD4 T cells are the 
target of current vaccines, it is not clear that 
these cells are the best mediators of 
protective immunity

Peter Andersen, Statens Serum Institut, Denmark
Vaccine-Induced Protection

Samuel M. Behar, Brigham and Women's Hospital, USA
CD8 T Cells in TB

Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Innate and Acquired Response to Pathogenic Organisms

Short Talks Chosen from Abstracts

08:00—11:00
Mycobacterial Diversity and Disease
Registered attendees can view abstracts starting on 02/13/2013

Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE/PPE Proteins in Mycobacteria

Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria Can Tell Us About Drug Resistance

Jeffery S. Cox, University of California, San Francisco, USA
Toxin-Anti-Toxin Systems and Persistence

Short Talks Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation


Following Session is for Host Response in Tuberculosis (X7)

14:30—16:30
Workshop 1: Host

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Vaccination Against Mtb (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: The availability of patients in close proximity to high tech tools for analysis of immune responses has resulted in an increase in our understanding of the human response to Mtb infection.

Daniel A. Portnoy, University of California, Berkeley, USA
Vaccines for Intracellular Pathogens

Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA
Early Results of Vaccine Trials in Humans

Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin, Germany
Current Vaccines

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, MARCH 16

07:00—08:00
Breakfast


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
The Consequences of the Immune Response in the Lung
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.

Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection

Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in TB

Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis

Short Talks Chosen from Abstracts

08:00—11:00
Life and Death in Mycobacteria
Registered attendees can view abstracts starting on 02/13/2013

Eric J. Rubin, Harvard School of Public Health, USA
Protein Degradation and Pathogenesis

Valerie Mizrahi, University of Cape Town, South Africa
Vitamin B12 Metabolism in Mycobacteria

Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance during Mtb Infections

Graham F. Hatfull, University of Pittsburgh, USA
Phages as Probes for Mycobacterial Physiology

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation


Following Session is for Host Response in Tuberculosis (X7)

14:30—16:30
Workshop 2: Bacteria

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
A Global View of Infection (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Unbiased techniques can highlight novel pathways and mechanisms of disease. This session will address the increased understanding of TB that these approaches have generated.

Sebastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolution of TB

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

Kanury V. S. Rao, International Centre for Genetic Engineering and Biotechnology, India
Host Factors in Resistance

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, MARCH 17

07:00—08:00
Breakfast


Following Session is for Host Response in Tuberculosis (X7)

08:00—11:00
Tuberculosis and HIV
Registered attendees can view abstracts starting on 02/13/2013

NOTE: These two pathogens interact to create 
devastating effects for human health. What is 
the future for vaccination and control in areas 
with high incidence of both.

Robert J. Wilkinson, University of Cape Town, South Africa
The Effect of HIV-1 Infection on the Human Immune Response to Mycobacterium tuberculosis

JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates

Daniel L. Barber, NIAID, National Institutes of Health, USA
Experimental Models of Pathogenic Immune Restoration in Tuberculosis

Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction

Short Talk(s) Chosen from Abstracts

08:00—11:00
The Bacterial Surface and its Interaction with the Host
Registered attendees can view abstracts starting on 02/13/2013

Mary Jackson, Colorado State University, USA
Lipid and Carbohydrate Metabolism in Mycobacteria

Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
Mycobacterial Protein Secretion

Michael Niederweis, University of Alabama at Birmingham, USA
Mycobacterial Porins

Short Talks Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Host Susceptibility to Disease (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: What are the factors that allow disease to develop in some exposed individuals and not others?

Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Erwin Schurr, Montreal General Hospital, McGill University, Canada
Host Susceptibility to Mtb

Speaker to be Announced

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


MONDAY, MARCH 18


Departure


*Session Chair †Speaker invited, not yet responded.

13 Mar - 18 Mar 2013
Whistler
Canada
meeting website