Host Response in Tuberculosis

Although the host response to tuberculosis has been studied for many years, we still have only a rudimentary working model of the disease process; namely that antigen-specific T cells activate infected macrophages to control bacterial growth. Further progress in the control of tuberculosis will depend on a much more detailed understanding of the nature of the host response to infection. Therefore, the purpose of this Keystone Symposia meeting is to reassess our current understanding of disease mechanisms, discuss the most recent advances in the field, and identify critical questions and future research directions. A key focus of the meeting will be the innate, acquired, and immunopathologic responses that occur in the host following exposure to Mycobacterium tuberculosis. Speakers will be strongly encouraged to move past dogma and promote critical re-analysis of our working model of what constitutes protective immunity to tuberculosis. The conference will be held concurrently with a meeting on Tuberculosis: Understanding the Enemy – covering bacterial genetics, bacterial physiology, systems biology, and drug development. This will provide opportunities for participants from different disciplines to interact with one another forge new collaborations in novel areas of biology. Importantly, the interactive nature of the meetings will promote the new ideas and novel approaches necessary to combat this devastating disease.
+ show speakers and program

WEDNESDAY, MARCH 13

16:00—20:00
Arrival and Registration


THURSDAY, MARCH 14

07:00—08:00
Breakfast

08:00—11:00
How Do Innate Cells Respond to Mtb (I)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: How does the lung respond to infection and ?how do the phagocyte and bacteria interact?

Larry S. Schlesinger, Ohio State University, USA
Early Lung Responses

Jennifer Philips, New York University School of Medicine, USA
EsxH ESCRTs TB to Safety by Arresting Phagosome Maturation

Helen A. Fletcher, University of Oxford, UK
Correlates of Risk of TB Disease in Infants Vaccinated with BCG

Short Talks Chosen from Abstracts


Following Session is for Tuberculosis: Understanding the Enemy (X8)

08:00—11:00
Mycobacterium tuberculosis – From Single Cells to Systems
Registered attendees can view abstracts starting on 02/13/2013

John D. McKinney, Swiss Federal Institute of Technology (EPFL), Switzerland
Single Cell Division Cycle Dynamics and Stress Responses

Veronique Anne Dartois, Public Health Research Institute, USA
Pharmacology, from Single Cells to Organisms

Johnjoe McFadden, University of Surrey, UK
Systems-Based Metabolic Analysis of Intracellular Growth

Short Talks Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

15:30—16:00
Coffee Available

16:00—17:00
Keynote Address - TB: The Continuing Challenge (Joint)
Registered attendees can view abstracts starting on 02/13/2013

Chris Dye, World Health Organization, Switzerland
Population Dynamics and Control of Tuberculosis

17:00—19:00
How Do Innate Cells Respond to Mtb (II) (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Mononuclear phagocytes are recognized as the host cells for Mtb but what do they really do? Neutrophils have been largely ignored as actors in tuberculosis, what do these cells do to contribute to disease? This session addresses these questions

Carl F. Nathan, Weill Cornell Medical College, USA
Mtb Needs a Strong Host Immune Response—But Not Too Strong: Mechanisms of Mycobacterial Immunomodulation

Anne O'Garra, MRC National Institute for Medical Research, UK
Immune Responses in Tuberculosis: From Mouse Models to Human Disease

David G. Russell, Cornell University, USA
Intracellular Survival by Mycobacterium: No Pressure!

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


FRIDAY, MARCH 15

07:00—08:00
Breakfast

08:00—11:00
Acquired Immunity - Beyond the CD4 T Cell/Macrophage Paradigm?
Registered attendees can view abstracts starting on 02/13/2013

NOTE: While antigen-specific CD4 T cells are the 
target of current vaccines, it is not clear that 
these cells are the best mediators of 
protective immunity

Peter Andersen, Statens Serum Institut, Denmark
Vaccine-Induced Protection

Samuel M. Behar, Brigham and Women's Hospital, USA
CD8 T Cells in TB

Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Innate and Acquired Response to Pathogenic Organisms

Short Talks Chosen from Abstracts


Following Session is for Tuberculosis: Understanding the Enemy (X8)

08:00—11:00
Mycobacterial Diversity and Disease
Registered attendees can view abstracts starting on 02/13/2013

Nico C. Gey van Pittius, University of Stellenbosch, South Africa
Evolution of the PE/PPE Proteins in Mycobacteria

Thomas Ioerger, Texas A&M University, USA
What Comparative Genomics of Mycobacteria Can Tell Us About Drug Resistance

Jeffery S. Cox, University of California, San Francisco, USA
Toxin-Anti-Toxin Systems and Persistence

Short Talks Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Host

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Vaccination Against Mtb (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: The availability of patients in close proximity to ?high tech tools for analysis of immune ?responses has resulted in an increase in our ?understanding of the human response to Mtb ?infection.

Daniel A. Portnoy, University of California, Berkeley, USA
Vaccines for Intracellular Pathogens

Thomas G. Evans, Aeras Global TB Vaccine Foundation, USA
Early Results of Vaccine Trials in Humans

Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin, Germany
Current Vaccines

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


SATURDAY, MARCH 16

07:00—08:00
Breakfast

08:00—11:00
The Consequences of the Immune Response in the Lung
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Cellular responses in the lung start slowly 
following challenge with Mtb and the 
inflammatory site remains dynamic for the 
period of infection. Understanding the 
dynamics of the cellular response will allow 
for improved intervention.

Denise Kirschner, University of Michigan, USA
A Systems Biology Approach to Uncovering Mechanisms Governing Host-Mycobacterial Interactions during TB Infection

Jon Friedland, Imperial College London, UK
Matrix Metalloproteinases in TB

Clifton E. Barry III, NIAID, National Institutes of Health, USA
The Dynamics of Human Tuberculosis

Short Talks Chosen from Abstracts


Following Session is for Tuberculosis: Understanding the Enemy (X8)

08:00—11:00
Life and Death in Mycobacteria
Registered attendees can view abstracts starting on 02/13/2013

Eric J. Rubin, Harvard School of Public Health, USA
Protein Degradation and Pathogenesis

Valerie Mizrahi, University of Cape Town, South Africa
Vitamin B12 Metabolism in Mycobacteria

Heran Darwin, New York University School of Medicine, USA
Pedal to the Metal: Copper Resistance during Mtb Infections

Graham F. Hatfull, University of Pittsburgh, USA
Phages as Probes for Mycobacterial Physiology

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Bacteria

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
A Global View of Infection (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: Unbiased techniques can highlight novel ?pathways and mechanisms of disease. This ?session will address the increased ?understanding of TB that these approaches ?have generated.

Sebastien Gagneux, Swiss Tropical and Public Health Institute, Switzerland
Evolution of TB

Jean-Laurent Casanova, Rockefeller University, USA
Toward a Genetic Theory of Infectious Diseases

Kanury V. S. Rao, International Centre for Genetic Engineering and Biotechnology, India
Host Factors in Resistance

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


SUNDAY, MARCH 17

07:00—08:00
Breakfast

08:00—11:00
Tuberculosis and HIV
Registered attendees can view abstracts starting on 02/13/2013

NOTE: These two pathogens interact to create 
devastating effects for human health. What is 
the future for vaccination and control in areas 
with high incidence of both.

Robert J. Wilkinson, University of Cape Town, South Africa
The Effect of HIV-1 Infection on the Human Immune Response to Mycobacterium tuberculosis

JoAnne L. Flynn, University of Pittsburgh School of Medicine, USA
Modeling HIV-TB Immune Interaction in Non-Human Primates

Daniel L. Barber, NIAID, National Institutes of Health, USA
Experimental Models of Pathogenic Immune Restoration in Tuberculosis

Richard A. Koup, NIAID, National Institutes of Health, USA
HIV-Tuberculosis Interaction

Short Talk(s) Chosen from Abstracts


Following Session is for Tuberculosis: Understanding the Enemy (X8)

08:00—11:00
The Bacterial Surface and its Interaction with the Host
Registered attendees can view abstracts starting on 02/13/2013

Mary Jackson, Colorado State University, USA
Lipid and Carbohydrate Metabolism in Mycobacteria

Keith M. Derbyshire, Wadsworth Center, New York State Department of Health, USA
Mycobacterial Protein Secretion

Michael Niederweis, University of Alabama at Birmingham, USA
Mycobacterial Porins

Short Talks Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Host Susceptibility to Disease (Joint)
Registered attendees can view abstracts starting on 02/13/2013

NOTE: What are the factors that allow disease to 
develop in some exposed individuals and not 
others?

Hardy Kornfeld, University of Massachusetts Medical School, USA
Diabetes and TB

Erwin Schurr, Montreal General Hospital, McGill University, Canada
Host Susceptibility to Mtb

Speaker to be Announced

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


MONDAY, MARCH 18


Departure


*Session Chair †Speaker invited, not yet responded.

13 Mar - 18 Mar 2013
Whistler
Canada
meeting website