Growing to Extremes: Cell Biology and Pathology of Axons

Neuronal communication is essential for every movement, sensation and thought in motile animals, and the axonal extensions of neurons provide all long-range communication to, from, and within the brain and spinal cord. Axons extend distances ranging from hundreds of microns to more than a meter in humans, lengths that both require specialized mechanisms for formation and maintenance, and increase the risk of degeneration and dysfunction upon injury or disease. Thus, diverse communities of basic researchers and clinicians must address problems rooted in axonal cell biology, but to date there is no meeting that serves as a central venue for this field. Axon biology meetings in the past have focused on specific sub-topics such as axon guidance, trophic factors, or neurodegeneration. This meeting will bring together the multiple disciplines required for accelerating progress in the field of axonal biology and pathology, providing a unique venue to bring together basic research on molecular and cellular biology of axons with clinical needs and industry interest. The conference will cover a broad spectrum of the latest developments in molecular and cellular axonal research, from development and maintenance, through to survival and repair, in both the central and peripheral nervous systems. Additional topics and late-breaking developments will be incorporated via talks selected from abstracts, specifically encouraging participation of junior researchers and those new to the field. The multidisciplinary theme and shared focus will facilitate communication across the entire continuum from basic to clinical neuroscience.
+ show speakers and program
SUNDAY, MARCH 10

16:00—20:00
Arrival and Registration

Pre Function

MONDAY, MARCH 11

07:00—08:00
Breakfast

Granhall
08:00—11:00
Axonal Specification, Cytoskeleton and Compartmentalization
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Frank Bradke, German Center for Neurodegenerative Diseases, Germany
Intracellular Mechanisms of Axonal Growth and Regeneration

Matthew N. Rasband, Baylor College of Medicine, USA
The Axon Initial Segment and the Maintenance of Neuronal Polarity

Franck Polleux, The Scripps Research Institute, USA
Molecular Mechanisms Specifying Cortical Neuron Polarity in vivo

Kozo Kaibuchi, Nagoya University Graduate School of Medicine, Japan
Neuronal Polarity in vitro and in vivo

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Axonal Growth Modalities
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Michael Fainzilber, Weizmann Institute of Science, Israel
Motor-Driven Frequency-Based Mechanisms for Axon Growth Control

Douglas H. Smith, University of Pennsylvania, USA
The Role of Dynamic Stretch Injury in Growth and Degeneration

Britta J. Eickholt, Charité – Universitätsmedizin Berlin, Germany
Talk Title to be Determined

Short Talk Chosen from Abstracts

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 1

Bay
20:00—21:00
Social Hour

Bay

TUESDAY, MARCH 12

07:00—08:00
Breakfast

Granhall
08:00—11:00
Molecular Motors and Axonal Transport Regulation
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Richard Vallee, Columbia University, USA
Regulation of Cytoplasmic Dynein Motor Function

Erika Holzbaur, University of Pennsylvania, USA
Regulation of Dynein-Dependent Retrograde Transport in Health and Disease Models

Valeria Cavalli, Washington University, USA
Kinesin-1-Dependent Transport in Axon Growth and Regeneration

Frédéric Saudou, Institut Curie, France
Role of Huntingtin in Vesicular Trafficking along Axons

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay

On Own for Lunch and Recreation

14:30—16:30
Workshop

Mountain/Lake
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Axonal Membrane Dynamics and Organelle Transport
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Giampietro Schiavo, London Research Institute, UK
In vivo Imaging of Axonal Transport in Health and Disease

Rejji Kuruvilla, Johns Hopkins University, USA
Regulation of Neuronal Development by Trafficking of Neurotrophins and their Receptors

Thomas L. Schwarz, Children's Hospital Boston and Harvard Medical School, USA
Regulating Mitochondrial Movement along Axons in Health and Disease

Short Talk Chosen from Abstracts

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 2

Bay
20:00—21:00
Social Hour

Bay

WEDNESDAY, MARCH 13

07:00—08:00
Breakfast

Granhall
08:00—11:00
RNA Targeting and Local Translation
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Jeffery L. Twiss, Drexel University, USA
mRNAs Compete for Limited Quantities of Transport Machinery

Antonella Riccio, University College London, UK
Neurotrophin-Dependent RNA Transport in Axons

James Fawcett, University of Cambridge, UK
Developmental Regulation of the Axonal mRNA Repertoire

Mustafa Sahin, Children's Hospital Boston, USA
TSC-mTOR Signaling Regulates Axonal mRNA Translation

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Pre Function
11:00—13:00
Poster Setup

Bay
13:00—22:00
Poster Viewing

Bay

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Pre Function
17:00—19:00
Axonal Signaling
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
David G. Ginty, Johns Hopkins University School of Medicine, USA
Organization and Development of Neurons that Underlie the Sense of Touch

Gary R. Lewin, Max Delbrück Center for Molecular Medicine, Germany
Signaling Touch and Pain in the Peripheral Nervous System

Mark H. Tuszynski, University of California, San Diego, USA
From Neuronal Signaling to Axon Regeneration

Short Talk Chosen from Abstracts

19:00—20:00
Dinner

Granhall
19:30—22:00
Poster Session 3

Bay
20:00—21:00
Social Hour

Bay

THURSDAY, MARCH 14

07:00—08:00
Breakfast

Granhall
08:00—11:00
Axonal Maintenance
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Christine Beattie, Ohio State University, USA
Mechanisms of Motoneuron Dysfunction – from Zebrafish to Humans

Avraham Yaron, Weizmann Institute of Science, Israel
Mechanisms of Axonal Maintenance and Degeneration

Joe Lewcock, Genentech, Inc., USA
Intracellular Pathways that Underlie Neurodegeneration in Development and Disease

Guo-li Ming, Johns Hopkins University, USA
Talk Title to be Determined

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Pre Function

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Pre Function
17:00—18:15
Axon-Glia Interactions
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Klaus-Armin Nave, Max Planck Institut of Experimental Medicine, Germany
The Role of Glia in Axonal Development and Maintenance

Bruce D. Carter, Vanderbilt University School of Medicine, USA
Molecular Mechanisms of Peripheral Myelin Formation

Short Talk Chosen from Abstracts

18:15—19:15
Closing Keynote Address
Registered attendees can view abstracts starting on 02/10/2013

Mountain/Lake
Martin E. Schwab, University of Zurich, Switzerland
Axon Growth and Regeneration, from Basic to Clinic

19:15—20:00
Dinner

Granhall
19:15—20:00
Social Hour

Granhall
20:00—23:00
Entertainment

Granhall

FRIDAY, MARCH 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 Mar - 15 Mar 2013

Tahoe City
United States of America
meeting website