DNA Replication and Recombination

Cells universally rely on faithful genome duplication and maintenance for propagation and survival. Although frequently considered as independent systems or events, in recent years it has become clear that three of the most fundamental processes that support chromosome integrity and cell proliferation – DNA replication, repair, and recombination – are highly interconnected. At present, how these connections are manifest and controlled at a molecular level is not understood. Although significant advances have been made in identifying and understanding many of the machineries that govern these transactions, our knowledge of their fundamental molecular mechanisms is likewise incomplete. Aberrant replicative and repair-based processes have been firmly linked to biomedical problems such as mutation, tumorigenesis and numerous inherited diseases. Nonetheless, our understanding of how such detrimental phenotypes arise is still quite limited. This meeting aims to bring together scientists working at the forefront of DNA replication, recombination and repair under one umbrella. Topic sessions have been selected to delve into the interconnections between these fields in great detail, while at the same time highlighting the basic operating principles that link together the structure, function, and regulation of multiple systems that support chromosome viability and transmission. Talks at this meeting will describe the field’s most recent efforts to uncover new concepts in molecular function and cellular control, and to discover new proteins, interactions, and processes that can serve as targets both for understanding the genetic basis for disease (notably cancer) and for therapeutic intervention. Example topics include probing how replication forks respond to different types of DNA damage events, how DNA repair enzymes interface with the replisome and decide how best to mend a particular lesion, how recombination and other repair systems are used to heal and restart stalled forks, and how the telomeric ends of chromosomes are both replicated and play key roles in managing chromosome stability. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Genomic Instability and DNA Repair, which will share a keynote address and two plenary sessions with this meeting.
+ show speakers and program
SUNDAY, MARCH 3

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 02/03/2013

Frederick W. Alt, HHMI/Children's Hospital Boston and Immune Disease Institute, USA
Mechanisms of Normal and Aberrant Recombination and Repair Processes in Lymphocytes

Kenneth J. Marians, Memorial Sloan-Kettering Cancer Center, USA
Mechanisms of Replication Restart


MONDAY, MARCH 4

07:00—08:00
Breakfast

08:00—11:00
Mechanisms and Control of DNA Repair/Mechanisms of Homologous Recombination (Joint)
Registered attendees can view abstracts starting on 02/03/2013

Stephen C. Kowalczykowski, University of California, Davis, USA
Single-Molecule Analysis of Recombination

Maria Jasin, Memorial Sloan-Kettering Cancer Center, USA
Control of DNA Repair by BRCA1 and BRCA2

Wolf-Dietrich Heyer, University of California, Davis, USA
Mechanisms of Regulating Recombination

Roland Kanaar, Erasmus University, Netherlands
Mechanism and Control of Homologous Recombination

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Regulation of DNA Superstructure

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Postreplication Repair/Restart
Registered attendees can view abstracts starting on 02/03/2013

Johannes C. Walter, Harvard Medical School, USA
The Mechanism of Replication-Coupled DNA Interstrand Cross-Link Repair

James E. Haber, Brandeis University, USA
Repair of Broken Yeast Chromosomes by Recombination

Wei Yang, National Institutes of Health, USA
Repair Polymerase Mechanisms

Short Talk Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

17:00—19:00
Chromosomal Stability, Instability and Nuclear Architecture
Registered attendees can view abstracts starting on 02/03/2013

Jiri Lukas, Danish Cancer Society, Denmark
DNA Repair and Chromosomal Fragility

Evi Soutoglou, Institute of Genetics and Molecular and Cellular Biology, France
Nuclear Architecture and Responses to DNA Damage

Speaker to be Announced

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, MARCH 5

07:00—08:00
Breakfast

08:00—11:00
Replication Initiation Strategies across Species
Registered attendees can view abstracts starting on 02/03/2013

* Stephen P. Bell, Massachusetts Institute of Technology, USA
Activation of the Eukaryotic Replicative DNA Helicase

Terry L. Orr-Weaver, Massachusetts Institute of Technology, USA
Changes in Gene Copy Number as a Developmental Strategy and DNA Replication Model

Leemor Joshua-Tor, Cold Spring Harbor Laboratory, USA
Viral Initiation Mechanisns

James M. Berger, University of California, Berkeley, USA
Bacterial Initiation Mechanisms

Short Talk(s) Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

08:00—11:00
Controlling DNA Damage Responses by Ubiquitylation and Sumoylation
Registered attendees can view abstracts starting on 02/03/2013

Daniel Durocher, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Canada
Ubiquitylation Control of Double-Strand Break Responses

Stephen P. Jackson, University of Cambridge, UK
Assembly and Disassembly of DNA Repair Complexes by Regulated Ubiquitylation

Dana Branzei, FIRC Institute of Molecular Oncology, Italy
Sumoylation at the DNA Replication Fork

Alan D. D'Andrea, Dana-Farber Cancer Institute, USA
Fanconi Anemia Pathway and its Control by Ubiquitylation

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop 2: DNA Repair Processes

Short Talks Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

14:30—16:30
Workshop 1: DNA-Damage Checkpoint Signaling

Short Talks Chosen from Abstracts

14:30—16:30
Workshop 3: DNA Replication Processes

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Replication, Chromatin and Genome Instability (Joint)
Registered attendees can view abstracts starting on 02/03/2013

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
Recombinational Repair and Heterochromatin

Ian D. Hickson, University of Copenhagen, Denmark
Processing of Late Replication Intermediates

Susan M. Gasser, Friedrich Miescher Institute for Biomedical Research, Switzerland
Chromatin, DNA Damage and DNA Replication

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, MARCH 6

07:00—08:00
Breakfast

08:00—11:00
Genome Structure and Maintenance
Registered attendees can view abstracts starting on 02/03/2013

* Lorraine S. Symington, Columbia University, USA
Control of Crossover Formation

* Simon J. Boulton, London Research Institute, Clare Hall Laboratories, UK
Genome Stability and the Regulation of Recombination

Stephen C. West, London Research Institute, UK
Making and Breaking Recombination Intermediates

Richard D. Kolodner, Ludwig Institute for Cancer Research, USA
Mechanisms of Gross Chromosomal Rearrangements

Short Talk(s) Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

08:00—11:00
Genome Instability, Telomeres, Disease and Aging
Registered attendees can view abstracts starting on 02/03/2013

Titia de Lange, Rockefeller University, USA
Telomeres and Responses to DNA Damage

Jan H. J. Hoeijmakers, Erasmus, Netherlands
The Central Role of DNA in Cancer, Aging and Longevity

Laura J. Niedernhofer, University of Pittsburgh Cancer Institute, USA
XPF and its Links to Cancer and Aging

Keith W. Caldecott, University of Sussex, UK
DNA Repair Defects Associated with Neurodegenerative Diseases

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Topological Transformations in DNA
Registered attendees can view abstracts starting on 02/03/2013

* Phoebe Rice, University of Chicago, USA
Structure and Function of Site-Specific Resolvases

Camilla Sjögren, Karolinska Institutet, Sweden
Regulation of DNA Topology

Claire Wyman, Erasmus Medical Center, Netherlands
Single-Molecule Analysis of DNA Pairing

Short Talk Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

17:00—19:00
DNA Damage and Links to Transcription, RNA Metabolism and Other Processes
Registered attendees can view abstracts starting on 02/03/2013

Andrés Aguilera, Andalusian Molecular Biology and Regenerative Medicine Centre, Spain
Transcription-Induced DNA Damage and Recombination

Michael B. Yaffe, Massachusetts Institute of Technology, USA
RNA and RNA Binding Proteins in the DNA Damage Response

Karlene A. Cimprich, Stanford University, USA
Transcription-Induced Genome Instability

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, MARCH 7

07:00—08:00
Breakfast

08:00—11:00
Replication Elongation Machineries
Registered attendees can view abstracts starting on 02/03/2013

David J. Sherratt, University of Oxford, UK
High-Resolution in vivo Analysis of Bacterial Chromosome Replication and Recombination

* Peter M. Burgers, Washington University School of Medicine, USA
Structure and Fidelity of DNA Polymerases at the Replication Fork

Stephen D. Bell, University of Oxford, UK
Archaeal DNA Replication

Linda B. Bloom, University of Florida, USA
Clamp Loading Mechanisms

Short Talk(s) Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

08:00—11:00
Genomic and Genome-Wide Studies
Registered attendees can view abstracts starting on 02/03/2013

Michael Stratton, Wellcome Trust Sanger Institute, UK
Genome Instability in Cancer

David Cortez, Vanderbilt University Medical Center, USA
Identification and Characterization of Mammalian Genome Maintenance Proteins

Marcel Tijsterman, Leiden University Medical Center, Netherlands
C. elegans Screens for Genome Instability and DNA Repair Factors

Trey Ideker, University of California, San Diego, USA
A Conserved Map of Genetic Interactions Induced by DNA Damage

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

14:30—16:30
Workshop 4: Enzymes Acting on Nucleic Acids (Joint)

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

17:00—19:00
Replicating Challenging Regions
Registered attendees can view abstracts starting on 02/03/2013

Julia Promisel Cooper, London Research Institute, UK
Coordination of Telomeric Replication Fork Passage and Telomerase Activity

* Virginia A. Zakian, Princeton University, USA
Helicases that Promote Fork Progression

Joachim Lingner, EPFL, Switzerland
Telomeres and the Regulation of Telomerase

Short Talk Chosen from Abstracts


Following Session is for Genomic Instability and DNA Repair (X6)

17:00—19:00
Diagnostic and Therapeutic Applications
Registered attendees can view abstracts starting on 02/03/2013

Thomas Helleday, Karolinska Institutet, Sweden
Therapeutic Strategies for Cancer Based on DNA Repair Inhibition

Jos Jonkers, Netherlands Cancer Institute, Netherlands
DDR-based Therapeutic Strategies and Resistance Mechanisms

Óscar Fernández-Capetillo, Centro Nacional de Investigaciones Oncologicas, Spain
Targeting Oncogene-Induced Replication Stress for Cancer Therapy

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Mar - 8 Mar 2013
Banff
Canada
meeting website