Understanding Dendritic Cell Biology to Advance Disease Therapies

Tissue macrophages and dendritic cells (DC) are tissue hematopoietic cells that share the ability to sample the environment but have distinct function in tissue immunity. Controversies remain on the best way to distinguish macrophages from DC in vivo. Results in recent months have established that DC derive from a specific hematopoietic lineage in the bone marrow controlled by a unique molecular program distinct from other myeloid programs. Recent results have also established that DC are heterogeneous in origin and function and that dysregulated biology of DC subsets contribute to the pathogenesis of immune disease. The main goal of this Keystone Symposia meeting is to review recent developments in our understanding of basic DC biology and to discuss the relevance of these findings to the pathogenesis of human immune disease. Specifically, we will discuss the mechanisms that control DC differentiation in lymphoid and non-lymphoid tissues during the steady state and diseased state, both at the cellular and transcriptional levels. We will discuss recent developments in our understanding of the molecular control of three unique DC functions that include migration to of the lymph nodes, presentation antigens, and polarization of T cell immune responses. We will debate the role of DC in immune disease – including auto-immunity, inflammation and allergic disease – and address the recent controversy on the role of DC versus basophils in the induction of Th2 response. Specifically, we will discuss the recent discovery of the molecular signature of Langerhans cell histiocytosis, a poorly understood disease that results from the accumulation/proliferation of langerin+ DC. Finally, we will review the relevance of DC in therapy and the basic mechanisms of action of the cell vaccine “Provenge” that has recently been approved by the FDA for the treatment of prostate cancer. The Keystone Symposia meeting on Understanding Dendritic Cell Biology to Improve Human Disease will bring together physicians experts in autoimmune disease, allergy and cancer, immunologists, geneticists, cancer biologists and vaccinologists. We will also invite scientists from the pharmaceutical industry as well as Journal Editors to maximize the interactions between different members of our community and thereby improve our understanding of the key role that DC play in the modulation of human disease and in medicine.
+ show speakers and program
SUNDAY, MARCH 3

16:00—20:00
Arrival and Registration

Longs Peak Foyer

MONDAY, MARCH 4

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 02/03/2013

Michel C. Nussenzweig, Rockefeller University, USA
Ralph Steinman and the Dendritic Cell Discovery

09:00—12:00
Development of Tissue-Resident and Inflammatory DC
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
* Miriam Merad, Mount Sinai Medical Center, USA
The DC Lineage

Boris Reizis, Columbia University, USA
Regulation of DC and PDC Development

Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France
Transcriptional Profiling of DC Subsets

* Kenneth M. Murphy, Washington University School of Medicine, USA
Transcriptional Control of DC Development

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

Longs Peak Foyer
12:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

14:30—16:30
Workshop 1: DC and Macrophage Genomics

Grays Peak
* Bernard Malissen, Centre d'Immunologie de Marseille-Luminy, France

* Nir Hacohen, Massachusetts General Hospital, USA

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Transcriptional Control of DC Development and Function
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
Hideki Ueno, Baylor Institute for Immunology Research, USA
Functional Specialization of Human DC Subsets

Nir Hacohen, Massachusetts General Hospital, USA
Regulatory Networks Underlying Dendritic Cell Activation

* Bali Pulendran, Emory University, USA
Systems Analysis of Immune Response in Humans

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, MARCH 5

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Cell Biology and Antigen Processing
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
* Bart N. Lambrecht, Ghent University, Belgium
ER Stress and DC Function

Averil I. Ma, University of California, San Francisco, USA
Ubiquitination and DC Function

* Sebastian Amigorena, Institut Curie, France
Control of Antigen Presentatation by Human DC

Brian D. Brown, Mount Sinai School of Medicine, USA
MicroRNA Control of DC Development

Short Talk(s) to be Announced

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Regulation of DC Function

Grays Peak
* Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK

* Peter T. Lee, Cell Press, USA

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Molecular and Functional Aspects of DC Migration
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
Gwendalyn J. Randolph, Washington University, USA
Talk Title to be Determined

Reinhold Förster, Hannover Medical School, Germany
Intranodal Behavior of DC

Michael Sixt, Institute of Science and Technology Austria, Austria
Cytoskeletal Dynamics of Dendritic Cells

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, MARCH 6

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
DC Sensing of the Environment
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
Eicke Latz, University of Massachusetts Medical School, USA
Inflammasome Activation in Macrophages and DC

Monsef Benkirane, Institut de Genetique Humaine, France
DC HIV Interaction

* Caetano Reis e Sousa, Cancer Research UK, London Research Institute, UK
Cell Death Receptors for Cross-Presentation

* Laurence Zitvogel, Institut Gustave Roussy, France
DC Sensing of Cell Death

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Role of PDC in Immunity and Disease
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
* Yong-Jun Liu, Baylor Research Institute, USA
DNA Sensors in PDC

Marco Colonna, Washington University School of Medicine, USA
PDC in Host Defense

Toshiaki Ohteki, Tokyo Medical and Dental University, Japan
PDC Control of Mucosal Immunity

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, MARCH 7

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Role of DC in Pathogenesis
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
Federica Sallusto, Institute for Research in Biomedicine, Switzerland
DC Control of T Helper Cell Development

* William R. Heath, University of Melbourne, Australia
DC Control of Viral Immunity

* Steffen Jung, Weizmann Institute of Science, Israel
Control of Mucosal Immunity by DCs and Macrophages

Hamida Hammad, Ghent University, Belgium
Role of Dendritic Cells in the Pathogenesis of Asthma

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

14:30—16:30
Workshop 3: Role of DC in Pathogenesis

Grays Peak
* Zoltan Fehervari, Nature Publishing Group, UK

* A. Karolina Palucka, Baylor Institute for Immunology Research, USA

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—18:30
Harnessing DC Biology to Advance Disease Therapies
Registered attendees can view abstracts starting on 02/03/2013

Grays Peak
* Ira Mellman, Genentech, Inc., USA

Bana Jabri, University of Chicago, USA
DC in Celiac Disease

* Franck J. Barrat, Hoffmann-La Roche, USA
DC Control of Autoimmunity

A. Karolina Palucka, Baylor Institute for Immunology Research, USA
DC Vaccine and Target Against Cancer

18:30—19:15
Concluding Remarks
Registered attendees can view abstracts starting on 02/03/2013

Ira Mellman, Genentech, Inc., USA
Translating DC Biology into Medicine

19:15—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
20:00—23:00
Entertainment

Longs/Quandary Peaks

FRIDAY, MARCH 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Mar - 8 Mar 2013
Keystone
United States of America
meeting website