PI 3-Kinase and Interplay with Other Signaling Pathways

How metabolic pathways are regulated to meet the unique needs of tumor cells is not well understood, but mounting evidence suggests that metabolic regulation in cancer cells is intimately linked with the signal transduction pathways that control cell growth and proliferation. The PI3K-Akt-mTOR signaling pathway is one of the primary mechanisms for controlling tumor cell growth, survival, and motility in response to oncogenic signaling and extracellular cues. Genetic events resulting in inappropriate activation of this pathway are common in many cancers and, as a result, are a focus of both basic cancer research and drug discovery efforts in oncology. Although originally modeled as an independent and linear signaling cascade, today it is evident that the PI3K pathway also functions as a central hub for cross-talk in both vertical as well as reciprocal feedback regulation with other important signaling pathways. One of the most exciting advances in the field is the development of new inhibitors against this pathway. However, the rationale for inhibiting individual or multiple isoforms of PI3K/Akt/mTOR signaling remains a subject of intense debate. This meeting aims to bring together scientists and clinicians from academia and industry to discuss the opportunities and liabilities of targeting the PI3K- and related pathways in disease, drawing on human pathophysiology and genetics, preclinical models and clinical data with PI3K pathway inhibitors. A joint meeting addressing Tumor Metabolism will enhance opportunities for interdisciplinary interactions.
+ show speakers and program
SUNDAY, FEBRUARY 24

15:00—19:30
Arrival and Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Kevan M. Shokat, University of California, San Francisco, USA

* Jose Baselga, Massachusetts General Hospital, USA

* Christian Rommel, Amgen, Inc., USA

Peter K. Vogt, The Scripps Research Institute, USA
Oncogenes in the PI3K Pathway

Roger L. Williams, Medical Research Council, UK
The PI3K Pathway by Protein Structures


MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

Quandary Peak

Following Session is for Tumor Metabolism (X4)

08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Control of Tumor Cell Growth and Survival

08:00—11:00
PI3K/Akt/mTOR Pathway in Cancer (Clinical - Part 1)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Jose Baselga, Massachusetts General Hospital, USA
Breast Cancer

Charles L. Sawyers, Memorial Sloan-Kettering Cancer Center, USA
Overcoming Resistance to Targeted Therapies

Vito J. Palombella, Infinity Pharmaceuticals, Inc., USA
Development of Potent PI3K-delta/gamma Inhibitors

Yardena Samuels, NHGRI, National Institutes of Health, USA
Human Cancer Genetics

Short Talk(s) Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

09:00—11:15
Metabolic Regulation
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Almut Schulze, Cancer Research UK, UK
The Role of Glucose and Lipid Metabolism in Growth and Survival of Cancer Cells

Sally A. Kornbluth, Duke University Medical Center, USA
Metabolic Control of Cell Physiology

Linda Z. Penn, Ontario Cancer Institute, Canada
Understanding and Exploiting the Oncogenic Capacity of the Mevalonate Pathway

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
PI3K/Akt/mTOR Pathway (Clinical - Part 2)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* William R. Sellers, Novartis Institutes for BioMedical Research, USA
PI3Kalpha

Kui Lin, Genentech, Inc., USA
Akt

Christian Rommel, Amgen, Inc., USA
TORC1/2


Following Session is for Tumor Metabolism (X4)

17:00—19:00
Nutrient Sensing
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Eileen P. White, Rutgers University, USA
Autophagy as a Response to Nutrient Deprivation

Reuben J. Shaw, The Salk Institute, USA
Signaling Events to Cope with Energy Stress

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Amino Acid Sensing Mechanisms

19:00—20:00
Social Hour w/ Lite Bites

Quandary Peak
19:30—22:00
Poster Session 1

Quandary Peak

TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
PI3K/Akt/mTOR Pathway in Cancer (Clinical Translational)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Jeffrey Adam Engelman, Massachusetts General Hospital, USA
Resistance Mechanisms

Sebastian Nijman, CeMM, Austria
Resistance Mechanisms

* Lori Friedman, Genentech, Inc., USA
Combination Therapies

Speaker to be Announced

Short Talk(s) Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

08:00—11:00
Metabolic Adaptation
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Chi Van Dang, University of Pennsylvania, USA
Glutamine and Cellular Energetics

Karen H. Vousden, Beatson Institute for Cancer Research, UK
Metabolic Adaptation Controlled by p53

Eyal Gottlieb, Beatson Institute for Cancer Research, UK
Revealing New Metabolic Networks in Cancer

Matthew G. Vander Heiden, Massachusetts Institute of Technology, USA
Metabolic Pathways Important for Cell Growth

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
PI3K/mTOR Pathway - Signaling Networks (Preclinical)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Kevan M. Shokat, University of California, San Francisco, USA
Polypharmacological Targeting of The P13K/mTOR and Raf/Mek Pathways of Cancer

John Blenis, Harvard University Medical School, USA
Convergence and Integration of mTOR and Ras-ERK Signaling in Cancer

David M. Sabatini, Whitehead Institute for Biomedical Research, USA
Regulation of Growth by the mTOR Pathway

Short Talk Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

17:00—19:00
Understanding the Metabolic Network
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Eytan Ruppin, Tel Aviv University, Israel
Harnessing Genome Scale Metabolic Modeling to Study Cancer Metabolism

Joshua D. Rabinowitz, Princeton University, USA
Measuring Metabolic Flux

Speaker to be Announced

19:00—20:00
Social Hour w/ Lite Bites

Quandary Peak
19:30—22:00
Poster Session 2

Quandary Peak

WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
PI3K-Related Pathways (Preclinical)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Lewis C. Cantley, Harvard Medical School, USA
PI3K and Cancer Metabolism

Judith A. Varner, University of California, San Diego, USA
PI3Kgamma Control of Innate Immunity in Cancer

Karen M. Cichowski, Brigham and Women's Hospital, Harvard Medical School, USA
Developing Combination Therapies with PI 3-K/mTOR Pathway Inhibitors

Hong Wu, University of California, Los Angeles, USA
Hormone Cross-Talk Signaling

Short Talk(s) Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

08:00—11:00
Influence of the Microenvironment on Metabolism
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Jacques Pouysségur, University of Nice, France
Role of Oxygen in Controlling Cancer Metabolism

M. Celeste Simon, University of Pennsylvania, USA
Tumor Cell Adaptation to the Microenvironment

Amato J. Giaccia, Stanford University, USA
Oxygen Sensing and Metabolic Control

Salvador Moncada, University College London, UK
Sensing the Microenvironment to Influence Metabolism

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Quandary Peak
13:00—22:00
Poster Viewing

Quandary Peak

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
PI3K Pathway: Cross-Talk, Feedback, Scaffold (Preclinical)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Christian Rommel, Amgen, Inc., USA

Julian H. Downward, Cancer Research UK, UK
Links between RAS Family GTPases and PI3K Signaling

Neal Rosen, Memorial Sloan-Kettering Cancer Center, USA
Interplay Signaling

Pier Paolo Pandolfi, Beth Israel Deaconess Medical Center/Harvard Medical School, USA
Talk Title to be Determined

Short Talk Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

17:00—19:00
Insights from in vivo Experiments
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Tak W. Mak, Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital, UHN, Canada
Tumor Metabolism Insight from Mouse Models

Yanping Zhang, University of North Carolina, Chapel Hill, USA
Ribosomal Protein-Mdm2-p53 Signaling and Energy Metabolism

Ralph J. DeBerardinis, University of Texas-Southwestern Medical Center, USA
Measuring Metabolism and Metabolites in vivo

Speaker to be Announced
Imaging Glutamine Metabolism in Patient Tumors Using PET

19:00—20:00
Social Hour w/ Lite Bites

Quandary Peak
19:30—22:00
Poster Session 3

Quandary Peak

THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

Quandary Peak
08:00—11:00
PI3K-Related Pathways (Preclinical)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
* Bart Vanhaesebroeck, Barts and The London School of Medicine, UK
PI3K and Mitosis

Davide Ruggero, University of California, San Francisco, USA
Ribosome Signaling

Jonathan Hart, The Scripps Research Institute, USA
PI3K/mTOR/STAT Signaling

William A. Weiss, University of California, San Francisco, USA
Autophagy

Short Talk(s) Chosen from Abstracts


Following Session is for Tumor Metabolism (X4)

08:00—11:00
Targeting Metabolism
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Bing Lim, Genome Institute of Singapore, Singapore
Targeting Glycine Metabolism for Cancer Therapy

Speaker to be Announced
Targeting Fatty Acid Metabolism

Susan Critchlow, AstraZeneca, UK
Targeting Lactate Metabolism

Joan S. Brugge, Harvard Medical School, USA
Use of 3D Culture Models to Understand the Impact of Targeted Therapy on Metabolism

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
PI3K-Related Pathways (Preclinical)
Registered attendees can view abstracts starting on 01/24/2013

Grays Peak
David A. Fruman, University of California, Irvine, USA
Mechanism of mTOR Inhibitor Action in Lymphocytes

Brendan D. Manning, Harvard School of Public Health, USA
The TSC-mTOR Network in Cancer and Metabolism

Ramon Parsons, Columbia University, USA
PTEN Signaling


Following Session is for Tumor Metabolism (X4)

17:00—19:00
Influence of Metabolism on Epigenetic Regulation
Registered attendees can view abstracts starting on 01/24/2013

Longs Peak
Yue Xiong, University of North Carolina at Chapel Hill, USA
Influence of Metabolism on Signal Transduction

Kathryn E. Wellen, University of Pennsylvania, USA
Use of Metabolic Pathways to Sense Cell State

Katherine Yen, Agios Pharmaceuticals, USA
Influence of IDH Mutations on the Epigenetic State of Cells

19:00—20:00
Social Hour w/ Lite Bites

Quandary Peak
20:00—23:00
Entertainment

Quandary Peak

FRIDAY, MARCH 1


Departure


*Session Chair †Speaker invited, not yet responded.

24 Feb - 1 Mar 2013
Keystone
United States of America
meeting website