Stem Cell Regulation in Homeostasis and Disease

Stem cell regulation is critical for tissue development and maintenance. Defects in stem cell regulatory mechanisms are thought to contribute to many diseases, including congenital diseases, cancer and diseases of aging; therefore, these mechanisms are of interest to a diverse audience. Recent stem cell meetings have tended to focus on the interface of stem cells and cancer, or on reprogramming. This has left the majority of stem cell biologists with fewer forums that focus on the basic mechanisms that regulate stem cell function. And yet critical advances are occurring that give glimpses of new molecular mechanisms that regulate stem cell and tissue homeostasis. The goal of this Keystone Symposia meeting is to identify new and common mechanisms governing stem cell function and differentiation across tissues and across species. To address this, the meeting is organized into sessions according to distinct modes of stem cell regulation, without regard to species, in a way that might highlight novel paradigms of regulation. Speakers will be chosen, first and foremost, based on research quality, and then to cover broad areas of stem cell research. The program for this meeting is highly likely to attract a wide variety of investigators, many of whom might not otherwise interact. The focus on stem cell regulation in general provides an umbrella under which speakers from different areas of research (e.g., developmental biology, tissue growth and homeostasis, regeneration, cancer and aging) are being brought together in an environment that is highly conducive to cross-talk.
+ show speakers and program
SUNDAY, FEBRUARY 24

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 25

07:00—08:00
Breakfast

08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/24/2013

George Q. Daley, Children's Hospital Boston, USA
Disease Modeling in iPS Cells

09:00—12:00
Pluripotency and Disease Modeling
Registered attendees can view abstracts starting on 01/24/2013

Anjana Rao, La Jolla Institute for Allergy and Immunology, USA
DNA Methylation, TET Proteins and Pluripotency

Konrad Hochedlinger, Massachusetts General Hospital, USA
Sox2(+) Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice

Kathrin Plath, University of California, Los Angeles, USA
Insights into Reprogramming Mechanisms

Deepak Srivastava, Gladstone Institute of Cardiovascular Disease, USA
Talk Title to be Determined

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

12:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells and Regeneration
Registered attendees can view abstracts starting on 01/24/2013

Trista E. North, Beth Israel Deaconess Medical Center, USA
Metabolic Regulation of Hematopoietic Stem Cell Formation

Alejandro Sánchez Alvarado, HHMI/Stowers Institute for Medical Research, USA
Planaria

David T. Scadden, Massachusetts General Hospital and Harvard University, USA
The Pysiological Function of Mesenchymal Stem Cells

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 26

07:00—08:00
Breakfast

08:00—11:00
Niche Regulation of Stem Cell Function
Registered attendees can view abstracts starting on 01/24/2013

Allan C. Spradling, HHMI/Carnegie Institute, USA
Stem Cells and Tissue Homeostasis

Valerie Horsley, Yale University, USA
Skin Stem Cell Niche

Fiona Doetsch, Columbia University, USA
Stem Cells and their Niche in the Adult Mammalian Brain

Sean J. Morrison, HHMI/University of Texas Southwestern Medical Center, USA
Hematopoietic Stem Cell Niche

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Emerging Regulatory Mechanisms
Registered attendees can view abstracts starting on 01/24/2013

Iannis Aifantis, HHMI/New York University School of Medicine, USA
E3 Ligases in HSC Differentiation

K. J. Patel, MRC Laboratory of Molecular Biology, UK
Mechanisms to Prevent DNA Damage by Metabolites in Stem Cells

Yukiko M. Yamashita, University of Michigan, Ann Arbor, USA
Cellular Polarity, Germline Stem Cell Maintenance and Aging

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 27

07:00—08:00
Breakfast

08:00—11:00
RNA Regulation and Stem Cells
Registered attendees can view abstracts starting on 01/24/2013

Haifan Lin, Yale University, USA
RNA Stability in Fly Stem Cells

Robert H. Blelloch, University of California, San Francisco, USA
MicroRNA Regulation of Pluripotency

Richard Iain Gregory, Harvard Medical School, Children's Hospital, USA
Lin28, Let-7 and Stem Cells

Judith E. Kimble, University of Wisconsin-Madison, USA
Notch Signaling and an RNA Regulatory Network Control C. elegans Germline Stem Cells

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Stem Cells and Cancer
Registered attendees can view abstracts starting on 01/24/2013

Richard J. Gilbertson, St. Jude Children's Research Hospital, USA
Lineage Tracing in Normal Stem Cells and Cancer

Austin Gurney, OncoMed Pharmaceuticals, USA
Targeting Stem Cell Pathways in Cancer

Luis F. Parada, University of Texas Southwestern Medical Center, USA
Lineage Tracing in Brain Tumors

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 28

07:00—08:00
Breakfast

08:00—11:00
The Aging of Mitotic Cells
Registered attendees can view abstracts starting on 01/24/2013

Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Protein Quality Control in Stem Cells and Aging

Anne Brunet, Stanford University, USA
The Regulation of Stem Cell Aging

Manuel Serrano, Spanish National Cancer Center (CNIO), Spain
Tumor Suppressors and Lifespan

Norman E. Sharpless, University of North Carolina School of Medicine, USA
Regeneration and Aging

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Self-Renewal Pathways and Disease
Registered attendees can view abstracts starting on 01/24/2013

Alexandra Joyner, Memorial Sloan-Kettering Institute, USA
Sonic Hedgehog and the Regulation of Neural Stem Cells

Frederic J. de Sauvage, Genentech, Inc., USA
Targeting Sonic Hedgehog Signaling in Cancer

Fernando D. Camargo, Children's Hospital Boston, USA
Hippo Signaling

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, MARCH 1


Departure


*Session Chair †Speaker invited, not yet responded.

24 Feb - 1 Mar 2013
Banff
Canada
meeting website