Autophagy, Inflammation and Immunity

Autophagy is a lysosomal degradation pathway by which eukaryotic cells break down their own components to adapt to nutrient deprivation. In multicellular organisms, autophagy and autophagy proteins also play a key role in the orchestration of diverse aspects of cellular and organismal responses to multiple dangerous stimuli, including infection. Thus, autophagy and autophagy proteins represent a key nexus within the cell through which multiple cellular and organismal stresses are integrated. This emerging understanding has led to exciting recent advances that, together, begin to paint a picture of how autophagy and autophagy proteins are involved in multiple diseases. Of particular interest, recent studies reveal a crucial role for autophagy pathways and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune, and inflammatory diseases. The time is therefore ripe for a Keystone meeting that brings together researchers from a variety of fields to focus on emerging themes and concepts in 'Autophagy, Inflammation, and Immunity'. Key advances in this area include the identification of signaling pathways that regulate autophagy, inflammation, and immunity and the finding that inflammation, immunity and autophagy are tightly, and reciprocally, intertwined. The goal of this meeting will be to relate the cell biology and signaling pathways that regulate autophagy and autophagy proteins to fundamental aspects of immunity and inflammation, as well as to diseases associated with alterations in these processes such as autoimmunity, infection, cancer, diabetes, the metabolic syndrome, and cardiovascular disease.
+ show speakers and program

SUNDAY, FEBRUARY 17

16:00—20:00
Arrival and Registration


MONDAY, FEBRUARY 18

07:00—08:00
Breakfast

QE1
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/17/2013

Douglas R. Green, St. Jude Children's Research Hospital, USA
Autophagy and the Immunological Impact of Dying Cells

09:00—11:15
Mechanisms of Autophagy
Registered attendees can view abstracts starting on 01/17/2013

Noboru Mizushima, Tokyo Medical and Dental University, Japan
Mammalian Atg Proteins in Autophagosome Formation

Sharon A. Tooze, London Research Institute, UK
Initiation of the Autophagosomal Membrane

Mark J. Daly, Harvard Medical School, USA
Autophagy Genes in Human Disease

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

11:15—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

QE2
17:00—19:00
Selective Autophagy and Infection
Registered attendees can view abstracts starting on 01/17/2013

Ivan Dikic, Goethe University Medical School, Germany
Autophagy Receptors and Bacterial Autophagy

Beth Levine, University of Texas Southwestern Medical Center, USA
Novel Mediators of Selective Virophagy and Mitophagy

Tamotsu Yoshimori, Osaka University, Japan
Mechanisms of Membrane Dynamics in Selective and Non-Selective Autophagy

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, FEBRUARY 19

07:00—08:00
Breakfast

08:00—11:00
Autophagy and Infection
Registered attendees can view abstracts starting on 01/17/2013

Pascale Cossart, Institut Pasteur, France
Autophagy and Cytosolic Bacteria

Robert L. Modlin, University of California, Los Angeles, USA
Vitamin D, Autophagy and Tuberculosis

Vojo Deretic, University of New Mexico, USA
Autophagy, Host Defense and Inflammation in Tuberculosis

Fulvio Reggiori, University Medical Centre Utrecht, Netherlands
The Autophagosomal Membrane and LC3-Positive Membranes Involved in Viral Infection

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

QE2
17:00—19:00
Autophagy and Immunity
Registered attendees can view abstracts starting on 01/17/2013

Speaker to be Announced
Late-Breaking Research

Herbert (Skip) W. Virgin IV, Washington University School of Medicine, USA
Autophagy Proteins and Macrophage-Based Immunity to Infection

Tatsuya Saitoh, Osaka University, Japan
Role of Atg14L1 in Autophagy and Immunity

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, FEBRUARY 20

07:00—08:00
Breakfast

08:00—11:00
Autophagy and the Inflammasome
Registered attendees can view abstracts starting on 01/17/2013

Gökhan S. Hotamisligil, Harvard University, USA
Metabolic Inflammasome

Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Fatty Acid Regulation of the Inflammasome

Augustine Choi, Harvard Medical School, USA
Autophagy, Mitochondria and the Inflammasome

Nobuhiko Kayagaki, Genentech, Inc., USA
The Non-Canonical Inflammasome and Caspase 11

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

QE2
17:00—19:00
Autophagy and Inflammatory Signaling
Registered attendees can view abstracts starting on 01/17/2013

Masaaki Komatsu, Tokyo Metropolitan Institute of Medical Science, Japan
Autophagy and the Nrf2-Keap 1 Pathway in Stress Response

Jorge Moscat, Sanford-Burnham Medical Research Institute, USA
p62: A Multifunctional Signaling Molecule in Inflammation and Metabolism

Sergio Grinstein, Hospital for Sick Children, Canada
PI3 Kinases and Reactive Oxygen Species in Phagosome Maturation

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, FEBRUARY 21

07:00—08:00
Breakfast

08:00—11:00
Autophagy in Metabolic and Inflammatory Disease
Registered attendees can view abstracts starting on 01/17/2013

Mark J. Czaja, Albert Einstein College of Medicine, USA
Autophagy and Lipid Metabolism

Ramnik Xavier, Massachusetts General/Broad Institute, USA
Autophagy Genes and Inflammatory Bowel Disease

Lora V. Hooper, University of Texas Southwestern Medical Center, USA
Intestinal Epithelial Cell Autophagy and the Microbiota

Thaddeus S. Stappenbeck, Washington University School of Medicine, USA
Autophagy Proteins and Regulation of Intestinal Inflammation

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

QE2
17:00—19:00
Autophagy in Cell Death and Cancer Immunity
Registered attendees can view abstracts starting on 01/17/2013

Eileen P. White, Rutgers University, USA
Autophagy in Tumor Cell Survival

Guido Kroemer, Institut Gustave Roussy, France
Autophagy-Dependent Anti-Tumor Immunity

Speaker to be Announced
Late-Breaking Research

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, FEBRUARY 22


Departure


*Session Chair †Speaker invited, not yet responded.

17 Feb - 22 Feb 2013
Montreal
Canada
meeting website