HIV Vaccines

Recent data in both humans and non-human primates suggest that a clinically useful HIV-1 vaccine is possible and that the use of therapeutic interventions can be an efficacious prevention strategy. The path forward will require a detailed understanding of the correlates of protection to HIV-1/SIV and the development of better immunogens to induce specific and long lasting immunity. Moreover, the role of vaccine elicited immune responses to prevent the initial stages of HIV-1 infection at mucosal sites will be critical toward understanding protective immunity. Scientific expertise from vaccine trials and studies of long term immunity will help inform decisions in the path to the induction of immunity by an HIV-1 vaccine. Furthermore, a better understanding of how to target an efficacious vaccine in diverse populations will require more detailed studies of host genetics, innate immune responses, the effect of therapeutic interventions and other host factors (that can affect the development of robust immune responses and/or the analysis of HIV-1 vaccine trials. At this meeting, leading experts from both within and outside the HIV field will present findings from recent advances in human and non-human primate trials on immune mechanisms of protection as well as implementation of efficacious vaccines and other preventative strategies in diverse populations. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on B Cell Development and Function – which will share a keynote session and two plenary sessions with this meeting. This pairing is explicitly designed to enhance opportunities for exchanges between researchers who do not typically interact. In this regard, it must be emphasized that a major roadblock in our efforts to generate a successful HIV vaccine relates to our limited knowledge of the B cell subsets and signals required for the durable production of protective class-switched HIV-1 neutralizing and inhibitory antibodies systemically and at mucosal sites.



This meeting is part of the Keystone Symposia Global Health Series.

Global Health Travel Award Deadline: September 11, 2012
+ show speakers and program

SUNDAY, FEBRUARY 10

15:00—19:30
Arrival and Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Myron S. Cohen, University of North Carolina Chapel Hill, USA
HIV Prevention: Lessons Learned and the Changing Landscape for HIV Vaccines

Michel C. Nussenzweig, Rockefeller University, USA
The Human Antibody Response to HIV


MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for B Cell Development and Function (X1)

08:00—11:00
B Cell Genesis
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Ana Cumano, Pasteur Institute, France
Mechanisms for B Cell Commitment of Hematopoietic Progenitors

Thomas Graf, Center for Genomic Regulation, Spain
Factors Regulating B Cell to Myeloid Cell Conversion

Rudolf Grosschedl, Max-Planck-Institute of Immunobiology, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation

Frederick W. Alt, HHMI/Children's Hospital Boston and Immune Disease Institute, USA
Regulation and Dysregulation of V(D)J Gene Recombination

08:00—11:00
Protective Responses in Animal Models
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
David H. O'Connor, University of Wisconsin-Madison, USA
Genetics and SIV Protection

Genoveffa Franchini, NCI, National Institutes of Health, USA
Correlates of Protection in NHP

Kevin O. Saunders, NIAID, National Institutes of Health, USA
Short Talk: The Passive Immunization and Transfer of VRC01 in Rhesus Macaques

Ruth M. Ruprecht, Dana-Farber Cancer Institute, USA
Passive Immunization Against Mucosal R5 SHIV Transmission

Sallie Permar, Duke University Medical Center, USA
Immune Protection Against Postnatal HIV/SIV Transmission

Short Talk Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Vaccine-Elicited Immune Responses and Potential Correlates

Quandary Peak
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for B Cell Development and Function (X1)

17:00—19:00
Early Events in B Cell Activation
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Facundo D. Batista, Cancer Research UK, London Research Institute, UK
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue

Michael Reth, Max Planck Institute of Immunobiology and Epigenetics, Germany
Role of Protein Islands for the Activation of B Cells

Susan K. Pierce, NIAID, National Institutes of Health, USA
Molecular Assembly of BCR Oligomers

Short Talk Chosen from Abstracts

17:00—19:00
Potentially Protective Responses in Human Clinical Trials
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Merlin L. Robb, Walter Reed Army Institute of Research, USA
Key Findings from RV Studies

Glenda Gray, University of the Witwatersrand, South Africa
Key Findings from South African Trials

Barney S. Graham, NIAID, National Institutes of Health, USA
Active and Passive Immunity Against HIV

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for B Cell Development and Function (X1)

08:00—11:00
B Cell Evolution and Repertoire Selection
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Max D. Cooper, Emory University, USA
Evolution of Adaptive Immunity in Vertebrates

Garnett H. Kelsoe, Duke University Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells

Hedda Wardemann, Max-Planck Institute for Infection Biology, Germany
V(D)J Gene Repertoire in Adult B Cells

Michael S. Neuberger, Medical Research Council, UK
Mechanisms of Somatic Hypermutation and Class Switch Recombination via AID

Short Talk(s) Chosen from Abstracts

08:00—11:00
Quality of Immune Response (Immune Geography and Memory)
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function

Jacob D. Estes, NCI, National Institutes of Health, USA
Early Events Following SIV Challenge

Mario Roederer, NIAID, National Institutes of Health, USA
Determination of Immune Response Quality

Speaker Chosen from Abstracts

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mucosal Antibody Responses (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation and Function of Mucosal IgA and IgD in Humans

Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan
IgA Class Switching in Intestinal Follicles

Andrew J. Macpherson, University of Bern, Switzerland
IgA Against Commensal Intestinal Microbes - Induction and Function

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for B Cell Development and Function (X1)

08:00—11:00
Germinal Center, Plasma Cell and Memory B Cell Differentiation
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Carola G. Vinuesa, Australian National University, Australia
Role of T Follicular Helper Cells in the Germinal Center Reaction

Jason G. Cyster, University of California, San Francisco, USA
In vivo Trafficking of Follicular B Cells

Jacques F. Banchereau, , USA
Regulation of Human Plasma Cell Differentiation

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
In vivo Trafficking of Follicular B Cells

Short Talk(s) Chosen from Abstracts

08:00—11:00
CD8 and CD4 T Cell Immunity
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Hendrik Streeck, Massachusetts General Hospital, Harvard Medical School, USA
Impact of CD4 T Cell Help/TFH Cells

Olivier Lambotte, INSERM U1012, France
Cellular Control of HIV-1 Infection

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses

Barbara L. Shacklett, University of California, Davis, USA
T Cell Immunity: Systemic and Mucosal

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Immune Memory

Quandary Peak
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Protective Antibody Responses Against HIV (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Barton F. Haynes, Duke University Medical Center, USA
Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies to HIV Envelope

Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Neutralizing Epitopes on HIV Envelope

Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV

Georgia D. Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Immune Responses

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for B Cell Development and Function (X1)

08:00—11:00
MicroRNAs and B Cell Neoplasias
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Louis M. Staudt, NCI, National Institutes of Health, USA
Biology and Treatment of B Cell Lymphoma

David Baltimore, California Institute of Technology, USA
MicroRNAs, Inflammation and Cancer

Riccardo Dalla-Favera, Columbia University, USA
Molecular Pathogenesis of B Cell Lymphoma

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells

Short Talk(s) Chosen from Abstracts

08:00—11:00
New Concepts in Innate Immunity and Stimulation
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Nina Bhardwaj, New York University School of Medicine, USA
Innate Stimulation

Steven Reed, Infectious Disease Research Institute, USA
Novel Adjuvants and Immune Stimulation

Karin Loré, Karolinska Institutet, Sweden
Innate Stimulation for Generating Potent HIV Immune Responses

Short Talks Chosen from Abstracts

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for B Cell Development and Function (X1)

17:00—19:00
Autoimmunity and Regulatory B Cells
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Betty Diamond, Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells

Robert Brink, Garvan Institute of Medical Research, Australia
Censoring Self-Reactive B Cells in the Germinal Center Reaction

Edgar G. Engleman, Stanford University, USA
B Cells and Insulin Resistance

Short Talk Chosen from Abstracts

17:00—19:00
Antibody Genomics and Immunogen Design
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
John R. Mascola, NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation

William Schief, The Scripps Research Institute, USA
Structure-Based HIV Vaccine Design

Susan W. Barnett, Novartis Vaccines and Diagnostics, Inc., USA
Selection of Envs and Adjuvants for Vaccine Evaluation

Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Chemical Modifications of Env for Vaccine Design

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
20:00—23:00
Entertainment

Colorado Rockies Ballroom

FRIDAY, FEBRUARY 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 Feb - 15 Feb 2013
Keystone
United States of America
meeting website