B Cell Development and Function

This meeting will provide an overview of the most recent advances in the biology of B cells. In addition to covering the function of B cells under steady-state conditions and infection, the meeting will provide an update on the alterations of B cells in autoimmunity, leukemia and lymphoma. The mechanisms by which B cells crosstalk with different components of the innate and adaptive immune systems and the contribution of distinct B cell subsets to systemic and mucosal immunity remain unclear, particularly in humans. This meeting has the following specific aims: 1) to define the factors involved in B cell lineage specification and reprogramming; 2) to elucidate the evolution and mechanisms of the processes underpinning antibody gene diversification; 3) to better understand the B cell pathways required for systemic and mucosal antibody responses against T cell-dependent and T cell-independent antigens; 4) to clarify the mechanisms by which antibodies provide protection against HIV; 5) to broaden our understanding of the molecular alterations associated with autoimmune and neoplastic B cell disorders; and 6) to provide an interactive forum to involve early stage investigators and highlight their discoveries. By addressing these problems, this meeting will not only generate new knowledge on the biology of B cells in health and disease states, but it will also provide a framework for investigators and clinicians to generate new ideas, initiate new collaborations, and eventually introduce changes in clinical practice. In addition, this meeting will provide a unique opportunity to “take a closer look” at B cells by linking experts in B cell biology with experts in stem cell biology, comparative immunology, molecular biology, and in vivo imaging. Additional opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on HIV Vaccines, which will share a keynote session and two plenary sessions with this meeting.
+ show speakers and program
SUNDAY, FEBRUARY 10

15:00—19:30
Arrival and Registration

Longs Peak Foyer
18:15—19:15
Refreshments

Longs Peak Foyer
19:15—21:30
Welcome and Keynote Session (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Myron S. Cohen, University of North Carolina Chapel Hill, USA
HIV Prevention: Lessons Learned and the Changing Landscape for HIV Vaccines

Michel C. Nussenzweig, Rockefeller University, USA
The Human Antibody Response to HIV


MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
B Cell Genesis
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Ana Cumano, Pasteur Institute, France
Mechanisms for B Cell Commitment of Hematopoietic Progenitors

Thomas Graf, Center for Genomic Regulation, Spain
Factors Regulating B Cell to Myeloid Cell Conversion

Rudolf Grosschedl, Max-Planck-Institute of Immunobiology, Germany
Mechanisms Underlying Transcriptional Control of B Cell Differentiation

Frederick W. Alt, HHMI/Children's Hospital Boston and Immune Disease Institute, USA
Regulation and Dysregulation of V(D)J Gene Recombination


Following Session is for HIV Vaccines (X2)

08:00—11:00
Protective Responses in Animal Models
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
David H. O'Connor, University of Wisconsin-Madison, USA
Genetics and SIV Protection

Genoveffa Franchini, NCI, National Institutes of Health, USA
Correlates of Protection in NHP

Kevin O. Saunders, NIAID, National Institutes of Health, USA
Short Talk: The Passive Immunization and Transfer of VRC01 in Rhesus Macaques

Ruth M. Ruprecht, Dana-Farber Cancer Institute, USA
Passive Immunization Against Mucosal R5 SHIV Transmission

Sallie Permar, Duke University Medical Center, USA
Immune Protection Against Postnatal HIV/SIV Transmission

Short Talk Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation


Following Session is for HIV Vaccines (X2)

14:30—16:30
Workshop 1: Vaccine-Elicited Immune Responses and Potential Correlates

Quandary Peak
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Early Events in B Cell Activation
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Facundo D. Batista, Cancer Research UK, London Research Institute, UK
Dynamic Imaging of Lymphocyte Activation - From Single Molecule to Living Tissue

Michael Reth, Max Planck Institute of Immunobiology and Epigenetics, Germany
Role of Protein Islands for the Activation of B Cells

Susan K. Pierce, NIAID, National Institutes of Health, USA
Molecular Assembly of BCR Oligomers

Short Talk Chosen from Abstracts


Following Session is for HIV Vaccines (X2)

17:00—19:00
Potentially Protective Responses in Human Clinical Trials
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Merlin L. Robb, Walter Reed Army Institute of Research, USA
Key Findings from RV Studies

Glenda Gray, University of the Witwatersrand, South Africa
Key Findings from South African Trials

Barney S. Graham, NIAID, National Institutes of Health, USA
Active and Passive Immunity Against HIV

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
B Cell Evolution and Repertoire Selection
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Max D. Cooper, Emory University, USA
Evolution of Adaptive Immunity in Vertebrates

Garnett H. Kelsoe, Duke University Medical Center, USA
Genetic Control of the First Tolerance Checkpoint in B Cells

Hedda Wardemann, Max-Planck Institute for Infection Biology, Germany
V(D)J Gene Repertoire in Adult B Cells

Michael S. Neuberger, Medical Research Council, UK
Mechanisms of Somatic Hypermutation and Class Switch Recombination via AID

Short Talk(s) Chosen from Abstracts


Following Session is for HIV Vaccines (X2)

08:00—11:00
Quality of Immune Response (Immune Geography and Memory)
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Ronald N. Germain, NIAID, National Institutes of Health, USA
Imaging Immune Cell Dynamics and Function

Jacob D. Estes, NCI, National Institutes of Health, USA
Early Events Following SIV Challenge

Mario Roederer, NIAID, National Institutes of Health, USA
Determination of Immune Response Quality

Speaker Chosen from Abstracts

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Mucosal Antibody Responses (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Andrea Cerutti, Mount Sinai School of Medicine, USA
Regulation and Function of Mucosal IgA and IgD in Humans

Sidonia Fagarasan, RIKEN Research Center for Allergy and Immunology, Japan
IgA Class Switching in Intestinal Follicles

Andrew J. Macpherson, University of Bern, Switzerland
IgA Against Commensal Intestinal Microbes - Induction and Function

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Germinal Center, Plasma Cell and Memory B Cell Differentiation
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Carola G. Vinuesa, Australian National University, Australia
Role of T Follicular Helper Cells in the Germinal Center Reaction

Jason G. Cyster, University of California, San Francisco, USA
In vivo Trafficking of Follicular B Cells

Jacques F. Banchereau, , USA
Regulation of Human Plasma Cell Differentiation

Tomohiro Kurosaki, WPI Immunology Frontier Research Center, Osaka University, Japan
In vivo Trafficking of Follicular B Cells

Short Talk(s) Chosen from Abstracts


Following Session is for HIV Vaccines (X2)

08:00—11:00
CD8 and CD4 T Cell Immunity
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Hendrik Streeck, Massachusetts General Hospital, Harvard Medical School, USA
Impact of CD4 T Cell Help/TFH Cells

Olivier Lambotte, INSERM U1012, France
Cellular Control of HIV-1 Infection

Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard, USA
Properties of Protective CD8 T Cell Responses

Barbara L. Shacklett, University of California, Davis, USA
T Cell Immunity: Systemic and Mucosal

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation


Following Session is for HIV Vaccines (X2)

14:30—16:30
Workshop 2: Immune Memory

Quandary Peak
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Protective Antibody Responses Against HIV (Joint)
Registered attendees can view abstracts starting on 01/10/2013

Columbine Ballroom
Barton F. Haynes, Duke University Medical Center, USA
Mechanisms of Protection by Broadly Reactive Neutralizing Antibodies to HIV Envelope

Peter D. Kwong, NIAID, National Institutes of Health, USA
Structural Biology of Neutralizing Epitopes on HIV Envelope

Dennis R. Burton, The Scripps Research Institute, USA
Antibody Protection Against HIV

Georgia D. Tomaras, Duke University Medical Center, USA
Spectrum of Vaccine-Elicited Humoral Immune Responses

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
MicroRNAs and B Cell Neoplasias
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Louis M. Staudt, NCI, National Institutes of Health, USA
Biology and Treatment of B Cell Lymphoma

David Baltimore, California Institute of Technology, USA
MicroRNAs, Inflammation and Cancer

Riccardo Dalla-Favera, Columbia University, USA
Molecular Pathogenesis of B Cell Lymphoma

Klaus Rajewsky, Max Delbrück Center for Molecular Medicine, Germany
MicroRNAs in Normal and Neoplastic B Cells

Short Talk(s) Chosen from Abstracts


Following Session is for HIV Vaccines (X2)

08:00—11:00
New Concepts in Innate Immunity and Stimulation
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
Nina Bhardwaj, New York University School of Medicine, USA
Innate Stimulation

Steven Reed, Infectious Disease Research Institute, USA
Novel Adjuvants and Immune Stimulation

Karin Loré, Karolinska Institutet, Sweden
Innate Stimulation for Generating Potent HIV Immune Responses

Short Talks Chosen from Abstracts

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Autoimmunity and Regulatory B Cells
Registered attendees can view abstracts starting on 01/10/2013

Longs/Grays Peaks
Betty Diamond, Feinstein Institute for Medical Research, USA
Negative Regulation of Peripheral Autoreactive B Cells

Robert Brink, Garvan Institute of Medical Research, Australia
Censoring Self-Reactive B Cells in the Germinal Center Reaction

Edgar G. Engleman, Stanford University, USA
B Cells and Insulin Resistance

Short Talk Chosen from Abstracts


Following Session is for HIV Vaccines (X2)

17:00—19:00
Antibody Genomics and Immunogen Design
Registered attendees can view abstracts starting on 01/10/2013

Quandary Peak
John R. Mascola, NIAID, National Institutes of Health, USA
Genetics of Antibody Elicitation

William Schief, The Scripps Research Institute, USA
Structure-Based HIV Vaccine Design

Susan W. Barnett, Novartis Vaccines and Diagnostics, Inc., USA
Selection of Envs and Adjuvants for Vaccine Evaluation

Quentin J. Sattentau, Sir William Dunn School of Pathology, UK
Chemical Modifications of Env for Vaccine Design

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
20:00—23:00
Entertainment

Colorado Rockies Ballroom

FRIDAY, FEBRUARY 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 Feb - 15 Feb 2013
Keystone
United States of America
meeting website