The Gut Microbiome: The Effector/Regulatory Immune Network

The mammalian GI track harbors a complex assemblage of microbial organisms that are essential for the development of the immune system. Alterations of the gut microbiota may lead to immune dysregulation both in the gut and in distal effector sites leading to the development of autoimmune disease. This meeting will focus on the role of the microbiota in balancing the effector and regulatory response leading to immune homeostasis. Recent findings suggest that altering certain bacterial populations present in the gut can lead to an inflammatory state associated with Th1/Th17 polarization. In contrast, other commensal bacteria and their antigenic products, when presented in the correct context, are regulatory and protect against inflammation. Particular emphasis will be placed on the biologic dynamics of the microbiota, the interaction with APC, modulation of the regulatory network and the immunologic consequences on experimental and human autoimmune conditions such as IBD, CNS demyelination and RA. The practical application of these novel interactions between the host and gut microbiota may lead to the identification of new therapeutics and novel insights into the mechanisms of human autoimmunity. The opportunity to assemble basic scientists in bacteriology and mucosal immunology with clinicians to explore this rapidly expanding arena is unique as there have been no previous organized meetings to meet this need. How the gut microbiome guides effector and regulatory immune functions will provide new pathways for the development of novel therapeutic targets.
+ show speakers and program
SUNDAY, FEBRUARY 10

16:00—20:00
Arrival and Registration

Chamisa Lobby

MONDAY, FEBRUARY 11

07:00—08:00
Breakfast

Los Vaqueros
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/10/2013

Chamisa Ballroom 1
Dan R. Littman, New York University School of Medicine, USA
The Gut Commensal Microbiota's Effects on Systemic Autoimmunity

09:00—23:15
The Gut Microbiome
Registered attendees can view abstracts starting on 01/10/2013

Chamisa Ballroom 1
Curtis Huttenhower, Harvard School of Public Health, USA
Large-Scale Genomic Data Mining of the Human Microbiome

David A. Relman, Stanford University, USA
Assembly, Stability and Resilience of the Human Microbiome

S. Dusko Ehrlich, Institut National de la Recherche Agronomique (INRA), France
The Human Metagenome

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

Chamisa Lobby
12:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Gut Microbiome and Immune Development
Registered attendees can view abstracts starting on 01/10/2013

Chamisa Ballroom 1
Chyi-Song Hsieh, Washington University, USA
Education of the Immune System by Commensal Microbiota

Ruth E. Ley, Cornell University, USA
Adaptive Immune Regulation of Bacterial Motility and Community Structure

Susan V. Lynch, University of California, San Francisco, USA
Gastrointestinal Microbiome and Pediatric Asthma Development

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

TUESDAY, FEBRUARY 12

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Gut Microbiome-APC Interactions
Registered attendees can view abstracts starting on 01/10/2013

NOTE: To appreciate the interaction between the gut microbiome and antigen presention such as dendritic cells, immunocytes that lead to the development or regulation of autoimmunity.

Chamisa Ballroom 1
B. Brett Finlay, University of British Columbia, Canada
The Interface between the Immune System and Microbiota in Infectious and Allergic Diseases

Dennis L. Kasper, Harvard Medical School, USA
Modulation of Immune Responses by Commensal Microbes

Brian L. Kelsall, NIAID, National Institutes of Health, USA
A Focus on Dendritic Cells and Macrophages as Key Regulators of Mucosal Immunity

Gérard Eberl, Institut Pasteur, France
Development and Function of Intestinal Innate Lymphoid Cells

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Experimental Colitis/IBD: Regulator Networks
Registered attendees can view abstracts starting on 01/10/2013

NOTE: This session will focus on the role of the microbiome in the development or regulation of both human and experiemental inflammatory bowel disease.

Chamisa Ballroom 1
Sarkis K. Mazmanian, California Institute of Technology, USA
Learning to Tolerate Our Microbial Self

Richard S. Blumberg, Brigham and Women's Hospital, USA
Microbial Exposure during Early Life Has Persistent Effects on Natural Killer T Cell Function

David Artis, University of Pennsylvania School of Medicine, USA
CD4(+) Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

WEDNESDAY, FEBRUARY 13

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Gut Bacteria Modulation of Effector Networks
Registered attendees can view abstracts starting on 01/10/2013

NOTE: The objective of this session is to evaluate the interaction of the gut microbiome and its capacity to polarize the immune response to either an effector or regulatory phenotype.

Chamisa Ballroom 1
Eric G. Pamer, Memorial Sloan-Kettering Cancer Center, USA
Regulation of Innate and Adaptive Immunity by the Commensal Microbiota

Nadine Cerf-Bensussan, Université Paris Descartes, France
The Variable Trade-Off between Commensal Bacteria and the Gut Immune System

Gabriel Nuñez, University of Michigan, USA
In Development of Natural Th17 Cell in the Intestine through IL-1b

Fiona M. Powrie, University of Oxford - NDM, UK
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Gut Modulation of Effector/Regulatory Networks in CNS Disease
Registered attendees can view abstracts starting on 01/10/2013

Chamisa Ballroom 1
Gurumoorthy Krishnamoorthy, Max Planck Institute of Neurobiology, Germany
Commensal Microbiota as a Trigger of Spontaneous Autoimmune Demyelination

Yun Kyung Lee, California Institute of Technology, USA
Proinflammatory T-Cell Responses to Gut Microbiota Promote Experimental Autoimmune Encephalomyelitis

Lloyd H. Kasper, Dartmouth Medical School, USA
Role of Commensal Bacteria in the Regulation of Central Nervous System Disease Demyelination

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

THURSDAY, FEBRUARY 14

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Modulation of Gut Microbiota and Autoimmunity
Registered attendees can view abstracts starting on 01/10/2013

Chamisa Ballroom 1
Peter J. Turnbaugh, Harvard University, USA
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice

Duccio Cavalieri, Università di Firenze, Italy
Microbiota in Children of Divergent Cultures

Fergus Shanahan, National University of Ireland, Ireland
Diet, Microbes and Metabolic Health

Javier Ochoa-Repáraz, EMD Serono, Inc., USA
The Gut as a Source of Small Molecule Therapeutics

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Chamisa Lobby

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Gut Bacteria Modulation of Autoimmunity
Registered attendees can view abstracts starting on 01/10/2013

NOTE: This is a continuation of the morning session regarding the interaction of the gut microbiome with other autoimmune conditions.

Chamisa Ballroom 1
Mogens Jakobsen, University of Copenhagen, Denmark
Gut Microbiota and Diabetes

Alexander Chervonsky, University of Chicago, USA
Innate Immune Signaling and the Gut Microbiota in Type 1 Diabetes

Christophe Benoist, Harvard Medical School, USA
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cell

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

FRIDAY, FEBRUARY 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 Feb - 15 Feb 2013
Taos
United States of America
meeting website