Lung Development, Cancer and Disease

Respiratory pathologies, including asthma, chronic obstructive pulmonary disease, lung cancer and fibrosis, impose significant health care burdens on populations throughout the world. The goal of this meeting is to bring together basic and clinical scientists studying a range of topics including: mechanisms underlying the embryonic development and maturation of the normal lung, endogenous stem cells and their role in repair and regeneration, the genetics of human lung diseases, and the cells-of-origin and progression of cancer and fibrosis. The format will be designed to promote critical discussion and debate and collaboration among participants who do not traditionally go to the same scientific meetings. The emphasis will be to stimulate new ways of thinking about old problems and new ideas about potential therapies. A common theme will be the question of how the different cell types in the lung – the epithelium, vasculature, mesenchyme and immune cells – interact during development and how these mechanisms may be disrupted or re-activated in association with disease initiation and progression. Based on participant feedback from the 2011 Keystone Symposia meeting on Lung Development and Repair there will be more workshop style sessions in which specific technical issues will be critically discussed, and junior clinician scientists and trainees can learn about different models of lung development, lung injury and repair, and lung stem cells. Other sessions will address emerging issues in lung biology, including new cellular therapies, the effect of environmental factors, and the identification of genes and pathways associated with rare lung diseases that have the potential to throw light on broader issues of lung biology.
+ show speakers and program
TUESDAY, FEBRUARY 5

16:00—20:00
Arrival and Registration

Chamisa Lobby

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Los Vaqueros
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Anton J.M. Berns, Netherlands Cancer Institute, Netherlands
Cell of Origin of Lung Cancer

09:00—12:00
Lung Development
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Mark A. Krasnow, Stanford University School of Medicine, USA
Genetic Dissection of Lung Development and Disease

James M. Wells, Cincinnati Children's Hospital Research Foundation, USA
Specification and Patterning of Foregut Endoderm

Xin Sun, University of Wisconsin, USA
Branching Morphogenesis of the Lung

Emma Rawlins, University of Cambridge, UK
Multipotent Epithelial Progenitor Cells in the Developing Lung

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

Chamisa Lobby
12:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

14:30—16:30
Workshop 1: Lung Cell Replacement

NOTE: Topics to include differentiation of iPSCs into lung endoderm and derivation of iPSCs from diseased lung, making artificial airways, and synthetic biopolymers as scaffolds for building new airways.

Chamisa Ballroom 1
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Specification, Differentiation and Patterning of Airway Epithelial Cell Lineages
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Transcription Factors in Lung Development and Disease

Eszter Katalin Vladar, Stanford University School of Medicine, USA
Mechanisms Regulating Epithelial Planar Cell Polarity in the Developing Lung

John F. Engelhardt, University of Iowa, USA
Development and Maintenance of the Submucosal Gland Stem/Progenitor Cell Niche

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 1

Chamisa Ballroom 2

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lung Cancer and COPD
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
David M. Ornitz, Washington University School of Medicine, USA
FGF Signaling Pathways in Lung Development and Cancer

Christin S. Kuo, Stanford University, USA
Neuroendocrine Cell Development and Small Cell Lung Cancer

Mary Armanios, Johns Hopkins School of Medicine, USA
Telomerase and its Role in Emphysema-Fibrosis Pathogenesis

Avrum Spira, Boston University, USA
The Airway Field of Injury in Lung Cancer and COPD

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Lung Mesodermal Lineages and Vascularization
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Patrick E. Bogard, Stanford University School of Medicine, USA
Development and the Lung Vasculature

Maya Kumar, Stanford University, USA
Embryonic Origin of Mesodermal Lineages in the Lung

Bruce C. Trapnell, University of Cincinnati College of Medicine, USA
GM-CSF, Lung Macrophages and PAP

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 2

Chamisa Ballroom 2

FRIDAY, FEBRUARY 8

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Alveolar Development, Vascular Remodeling and Alveolar Disease
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Tushar Desai, Stanford University, USA
Lung Adenocarcinoma and Alveolar Remodeling

Daniel B. Rifkin, New York University, USA
TGF-beta Signaling, Extracellular Matrix and Lung Development

Mark Looney, University of California, San Francisco, USA
Real-Time Imaging of Cell Trafficking in Lung Alveoli

Vladimir V. Kalinichenko, Cincinnati Children's Hospital Medical Center, USA
Transcriptional Regulation of Endothelial Cells during Lung Development and Alveolar Disease

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Chamisa Lobby
11:00—13:00
Poster Setup

Chamisa Ballroom 2
13:00—22:00
Poster Viewing

Chamisa Ballroom 2

On Own for Lunch and Recreation

14:30—16:30
Workshop 2: Models of Injury and Repair in the Lung: Basic Science and Novel Therapeutics

NOTE: Topics to include chemical induced injury and screens for small molecules promoting repair.

Chamisa Ballroom 1
Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
Lung Progenitor Cells and Lung Disease
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Brigid L.M. Hogan, Duke University Medical Center, USA
Airway Stem Cells

Frank McKeon, A*STAR/Harvard Medical School, USA
Lung Regeneration

Henry Danahay, Novartis Institutes for BioMedical Research, UK
Regulation of Cell Fate Decisions in the Airway

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
19:30—22:00
Poster Session 3

Chamisa Ballroom 2

SATURDAY, FEBRUARY 9

07:00—08:00
Breakfast

Los Vaqueros
08:00—11:00
Lung and Tissue Fibrosis
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Christine Kim Garcia, University of Texas Southwestern Medical Center at Dallas, USA
Cellular Stress and Lung Fibrosis

Andreas Günther, University of Giessen Lung Center, Germany
Signaling Mechanisms in Lung Fibrosis

Jeremy S. Duffield, University of Washington, USA
Pericytes and Tissue Fibrosis

Steven R. Ledbetter, Genzyme Corporation, USA
TGF-beta Signaling in Chronic Disease

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Chamisa Lobby

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Chamisa Lobby
17:00—19:00
New Insights from Genetic Analysis of Rare Lung Diseases
Registered attendees can view abstracts starting on 01/05/2013

Chamisa Ballroom 1
Enid R. Neptune, Johns Hopkins University, USA
Cellular Mechanisms Associated with Cutis laxa, Fibulins, TGF-beta and Lung Disease

Speaker to be Announced

Esteban Carlos Dell'Angelica, University of California, Los Angeles, USA
Molecular Basis of Hermansky-Pudlak Syndrome

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Chamisa Ballroom 2
20:00—23:00
Entertainment

Chamisa Ballroom 2

SUNDAY, FEBRUARY 10


Departure


*Session Chair †Speaker invited, not yet responded.

5 Feb - 10 Feb 2013
Taos
United States of America
meeting website