Neurogenesis

Formation of the nervous system starts with neurogenesis from neural stem cells in the developing embryo and continues throughout life in discrete regions of the adult brain. Defects in the developing and adult neurogenesis have been implicated in various mental disorders and degenerative neurological diseases. In recent years, tremendous progress has been made in understanding the cellular and molecular mechanism regulating neurogenesis from neural stem cells/progenitors in the developing and adult brain. This meeting will gather an interdisciplinary group of scientists using various experimental model systems to highlight latest advances in the neurogenesis field, including understanding of novel genetic and epigenetic mechanisms regulating developing and adult neurogenesis, disease modeling using patient-derived induced pluripotent stem cells, and identification of potential functions of adult neurogenesis and its contribution to mental disorder and degenerative neurological disorders. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent Keystone Symposia meeting on New Frontiers in Neurodegenerative Disease Research, which will share two plenary sessions with this meeting. In combination, these meetings will provide a platform for both speakers and participants to initiate extensive discussion and promote scientific collaborations on new directions.
+ show speakers and program
SUNDAY, FEBRUARY 3

16:00—20:00
Arrival and Registration

Sweeney Ballroom Foyer

MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Fred H. Gage, The Salk Institute for Biological Studies, USA
Neurogenesis and Neurological Disorders: Lessons from Studies of Adult Neurogenesis and Patient-Derived iPSCs


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
Susan Lindquist, HHMI/Whitehead Institute for Biomedical Research, USA
Modeling Pathology in Simpler Cells

09:00—12:00
Neurogenesis and Gliogenesis
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Gordon J. Fishell, New York University Medical Center, USA
The Role of Genetics and Activity in the Generation of Cortical Neuron Subtypes

Jonas Frisén, Karolinska Institutet, Sweden
Gliogenesis in Postnatal CNS

Dwight E. Bergles, Johns Hopkins University School of Medicine, USA
NG2+ OPCs and Role in ALS

Patrik Ernfors, Karolinska Institutet, Sweden
Cell Type Specificiation in the Neural Crest

Short Talk Chosen from Abstracts


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

09:00—12:00
Protein Aggregation and Propagation of Misfolded Proteins in the Brain
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
Virginia M. Y. Lee, University of Pennsylvania School of Medicine, USA
Protein Aggregation in Alzheimer’s Disease and Frontal Temporal Dementia

John Collinge, Institute of Neurology, University College London, UK
Prion Disease

Mathias Jucker, Universität Tübingen, Germany
Propagation of Misfolded Proteins in the Brain

Jeffery W. Kelly, The Scripps Research Institute, USA
Strategies to Ameliorate Neurodegenerative Diseases by Adapting the Proteostasis Network

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

Sweeney F, Main Level Breakouts
12:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts

Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

17:00—19:00
Mechanisms of Early Disease Intervention and Biomarkers
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
John Q. Trojanowski, University of Pennsylvania, USA
Alzheimer’s Biomarkers and Tau-Focused Therapies

Ronald B. DeMattos, Lilly Research Laboratories, USA
The Use of Biomarkers in the Development of AD Therapies

Rosa Rademakers, Mayo Clinic, USA
Frontal Temporal Dementia and Amyotrophic Lateral Sclerosis

Short Talk Chosen from Abstracts

17:00—19:00
Model Systems
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Tzumin Lee, HHMI/Janelia Farm Research Campus, USA
Lineage Analysis with Twin-Spot MARCM in Drosophila

Arnold Kriegstein, University of California, San Francisco, USA
oSVZ Neurogenesis in Developing Mouse and Human Cortex

Su-Chun Zhang, University of Wisconsin-Madison, USA
Generation of Diverse Neural Subtypes from Pluripotent Human Stem Cells

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Neurogenesis and Development: Molecular Mechanisms
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Yukiko Gotoh, University of Tokyo, Japan
Regulation of Neural Stem/Progenitor Cell Fate during Mouse Development

Soo-Kyung Lee, Oregon Health & Science University, USA
Gene Regulatory Networks in Spinal Cord Neurogenesis

Francois Guillemot, National Institute for Medical Research, UK
Transcriptional Control of Stem Cell Fates in the Embryonic and Adult Brain

Jenny Hsieh, University of Texas Southwestern Medical Center at Dallas, USA
Signaling Mechanism in Adult Neurogenesis

Short Talk(s) Chosen from Abstracts


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

08:00—11:00
Molecular Mechanisms of Neuronal Vulnerability
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
Myriam Heiman, Massachusetts Institute of Technology, USA
TRAPping Parkinson’s and Huntington’s Diseases

Michael R. Hayden, Xenon Pharmaceuticals Inc., Canada
Huntington's Disease

Valina L. Dawson, Johns Hopkins University School of Medicine, USA
Mechanisms of Cell Death in Neurodegeneration

Steven M. Paul, Weill Cornell Medical College, USA
ApoE, Amyloid Deposition and Abeta Clearance

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
Stem Cell Niches in the Developing and Adult Brain
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Christopher A. Walsh, Children's Hospital Boston, USA
Niche for Embryonic Cortical Neurogenesis

Andrea Brand, University of Cambridge, UK
Nutrient Control of Neural Stem Cells

Chay T. Kuo, Duke University Medical Center, USA
Sustaining New Neuron Production in the SVZ Niche

Short Talk Chosen from Abstracts


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

17:00—19:00
Novel Approaches for the Therapeutic Intervention of Neurodegenerative Disease
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
Anders Bjorklund, Lund University, Sweden
Blockade of alpha-Synuclein-Induced Neurodegeneration by Gene Therapy Approaches

Michael Hutton, Lilly UK, UK
Clearance of Tau

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Epigenetics and Genomics (Joint)
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-E
Yi Eve Sun, University of California, Los Angeles, USA
DNA Methylome during Developmental Neurogenesis

André Fischer, European Neuroscience Institute Göttingen, Germany
Histone Modifications in Degenerative Neurological Disorders

Daniel H. Geschwind, University of California, Los Angeles, USA
Functional Genomic Analyses of Pathways Dysregulated in Frontal Temporal Dementia

Hongjun Song, Johns Hopkins University School of Medicine, USA
Activity-Induced Modification of Neuronal DNA Methylome

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Sweeney F, Main Level Breakouts
11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
Adult Neurogenesis: Regulation and Functions
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Gerd Kempermann, Technische Universität Dresden, Germany
Systems Biology of Adult Neurogenesis and its Function

Pierre-Marie Lledo, Pasteur Institute, France
Adult Neurogenesis and Olfaction

Shaoyu Ge, SUNY Stony Brook, USA
Optogenetic Probing of Adult Neurogenesis Function

Short Talk Chosen from Abstracts


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

17:00—19:00
Aging and Genome Integrity
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
Bruce A. Yankner, Harvard Medical School, USA
DNA Damage in Aging and Neurodegenerative Disorders

Peter J. McKinnon, St. Jude Children's Research Hospital, USA
Defective DNA Damage Signaling and Neurodegeneration

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Genome Integrity, Chromatin Remodeling and Neurodegenerative Disorders

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakouts

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts
08:00—11:00
Adult Neurogenesis under Pathological Conditions
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-B
Xinyu Zhao, University of Wisconsin, USA
Adult Neurogenesis and Fragile X Syndrome

Heather A. Cameron, NIMH, National Institutes of Health, USA
Adult Neurogenesis, Stress and Depression

Randall Reed, Johns Hopkins University, USA
Olfactory Epithelium Neurogenesis after Injury

Jack M. Parent, University of Michigan, USA
Adult Neurogenesis after Injury

Short Talk(s) Chosen from Abstracts


Following Session is for New Frontiers in Neurodegenerative Disease Research (J8)

08:00—11:00
Neurobiology of Disease
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom C-E
David M. Holtzman, Washington University, USA
Regulation of beta-Amyloid by Neuronal Activity

Ted M. Dawson, Johns Hopkins School of Medicine, USA
Molecular Basis of Parkinson’s Disease

Li Gan, University of California, San Francisco, USA
Adult Stem Cells in Aging and Neurodegenerative Disorders

Marc Tessier-Lavigne, Rockefeller University, USA
Axon Degeneration in Development and Disease

Ryan J. Watts, Genentech, Inc., USA
Targeting Neurodegeneration by Boosting Antibody Uptake in Brain

09:00—09:20
Coffee Break

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Sweeney F, Main Level Breakouts
17:00—19:00
iPSC Modeling of Developmental and Degenerative Neurological Diseases (Joint)
Registered attendees can view abstracts starting on 01/03/2013

Sweeney Ballroom A-E
Guo-li Ming, Johns Hopkins University, USA
iPSCs Derived from Schizophrenia Patients with a DISC1 Mutation

Anirvan Ghosh, Hoffmann-La Roche, Switzerland
Small Molecule Screen of hESCs and Patient-Derived iPSCs

Kevin C. Eggan, Harvard University, USA
Modeling ALS Using iPSCs

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment

Sweeney F, Main Level Breakouts

FRIDAY, FEBRUARY 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Feb - 8 Feb 2013
Santa Fe
United States of America
meeting website