Mitochondria, Metabolism and Myocardial Function – Basic Advances to Translational Studies

The most common causes of heart failure are coronary artery disease, high blood pressure, and diabetes. Mitochondrial perturbations have been associated with heart failure itself and with most of the other preceding risk factors. In some cases mitochondrial dysfunction may play a causal role while in others mitochondria are a central target responsible for organ dysfunction. Understanding mitochondrial pathophysiology and identifying ways to ameliorate mitochondrial dysfunction is critical to therapy for cardiovascular disease. The continuous contractile function of the heart is required to sustain blood oxygenation, systemic circulation and nutrient supply to the body. This activity results in an unrelenting demand for energy production that is predominantly supported by mitochondrial oxidative phosphorylation. It is therefore not surprising that the mitochondria comprise about one third of cardiomyocyte volume, exhibit a promiscuous capacity to use energy substrates and possess biologic plasticity to maintain bioenergetic homeostasis. The centrality of mitochondria to sustain cardiac bioenergetics is additionally reflected in the development of cardiac pathology when mitochondria are dysfunctional. To counter this, a myriad of innate adaptive mitochondrial homeostatic programs are being identified. In the last two decades the investigations into mitochondrial biology with ever increasing discovery technologies, have enabled the scientific community to identify many novel programs controlling mitochondrial and metabolic function. The objectives of this conference are: to highlight the emerging adaptive programs identified in the heart orchestrating optimal mitochondrial homeostasis; to review how the emerging risk factors of obesity and diabetes disrupt mitochondrial and cardiac function, and to explore emerging metabolic targets for therapeutic interventions to modulate mitochondrial and metabolic perturbations associated with cardiac pathology.
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SUNDAY, FEBRUARY 3

16:00—20:00
Arrival and Registration

Longs Peak Foyer

MONDAY, FEBRUARY 4

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Ana Maria Cuervo, Albert Einstein College of Medicine, USA
Autophagy in Cellular Energy Balance

09:00—12:00
The Biology of Mitochondrial Homeostatic Regulatory Programs and Cardiac Disease
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Roberta Gottlieb, San Diego State University, USA
The Role of Mitophagy in Mitochondrial Biogenesis

Orian S. Shirihai, Boston University, USA
The Interplay between Mitochondrial Dynamics and Autophagy

Kinya Otsu, King's College London, UK
Mitochondrial DNA in the Development of Cardiac Inflammation and Dysfunction

Joseph A. Hill, University of Texas Southwestern Medical Center, USA
Autophagy and the Failing Heart

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

Longs Peak Foyer
12:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Regulation of Redox Stress in Cardiovascular Disease
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Junichi Sadoshima, University of Medicine and Dentistry of New Jersey, USA
The Role of NADPH Oxidases in Mediating Oxidative Stress in Mitochondria

Gerald S. Shadel, Yale University, USA
Mitochondrial ROS Signaling in Disease and Aging

Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center, USA
Novel Pathway Underlying Programmed Cellular Necrosis

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 1

Longs/Quandary Peaks

TUESDAY, FEBRUARY 5

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Metabolic Modulation in the Pathogenesis and Treatment of Cardiac Hypertrophy and Heart Failure
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Jan F. Glatz, Maastricht University, Netherlands
Novel Signaling Pathways Regulating Substrate Switching in the Heart

Martin E. Young, University Alabama Birmingham, USA
The Circadian Clock, Metabolic Regulation and Cardiac Pathology

Gary D. Lopaschuk, University of Alberta, Canada
Modulation of Malonyl-CoA and Cardiac Metabolic Consequences

William C. Stanley, University of Maryland, USA
Mitochondrial Pathology in Heart Failure: Novel Therapeutic Approaches

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Emerging Regulatory Programs in the Control of Mitochondria and Metabolism
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Elizabeth Murphy, NHLBI, NIH, Cardiac Physiology Section Vascular Medicine Branch, USA
S-Nitrosylation in the Control of Mitochondrial Stress Response

Michael N. Sack, NHLBI, National Institutes of Health, USA
Mitochondrial Protein Acetylation and the Control of Mitochondrial Metabolism

Eric N. Olson, University of Texas Southwestern Medical Center at Dallas, USA
The Role of MED13 in Regulating Cardiac Mitochondrial Metabolism and Systemic Insulin Resistance

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 2

Longs/Quandary Peaks

WEDNESDAY, FEBRUARY 6

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Nutrient Stressors and the Modulation of Cardiovascular Function
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Gökhan S. Hotamisligil, Harvard University, USA
ER Stress, Obesity and Atherosclerosis

E. Dale Abel, University of Utah School of Medicine, USA
Obesity-Mediated Disruption of Cardiac Mitochondrial Function

Jason Dyck, University of Alberta, Canada
Caloric Restriction and Cardiovascular Function

Daniel P. Kelly, Sanford-Burnham Medical Research Institute, USA
Myocyte Lipotoxicity Screening to Delineate Mechanisms and Drug Targets

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Longs/Quandary Peaks
13:00—22:00
Poster Viewing

Longs/Quandary Peaks

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Emerging Technologies to Characterize Mitochondrial and Metabolic Functioning
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Robert S. Balaban, NHLBI, National Institutes of Health, USA
Systems Biology of Mitochondria

Peipei Ping, University of California, Los Angeles, USA
Metabolic Lessons from Unbiased Large-Scale Proteomic Studies

Christopher B. Newgard, Duke University Medical Center, USA
Metabolomics Applied to Cardiovascular Diseases

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
19:30—22:00
Poster Session 3

Longs/Quandary Peaks

THURSDAY, FEBRUARY 7

07:00—08:00
Breakfast

Longs/Quandary Peaks
08:00—11:00
Novel Programs Controlling Mitochondria and Metabolism
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Vamsi K. Mootha, Massachusetts General Hospital, USA
Identification of the Mitochondrial Calcium Uniporter

Christine Des Rosiers, Montreal Heart Institute (MHI), Canada
Metabolomics: What Have We Learned from Heart Failure Patients?

Johan Auwerx, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland
Transcriptional Corepressors in the Control of Mitochondrial Homeostasis

Thomas Langer, University of Cologne, Germany
Quality Control of Mitochondrial Proteostasis

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Clinical Studies to Advance Biological Insight and Therapeutic Targets
Registered attendees can view abstracts starting on 01/03/2013

Grays Peak
Lawrence Young, Yale University, USA
AMPK and the Modulation of Mitochondrial Function

Patrick Schrauwen, Maastricht University Medical Center, Netherlands
Lipotoxicity, Mitochondria and Cardiac Function: Insight from Human Clinical Intervention Studies

Anthony J. Muslin, Novartis Institutes for BioMedical Research, Inc., USA
Modulation of Signaling Pathways to Treat Cardiovascular Disease

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Longs/Quandary Peaks
20:00—23:00
Entertainment

Longs/Quandary Peaks

FRIDAY, FEBRUARY 8


Departure


*Session Chair †Speaker invited, not yet responded.

3 Feb - 8 Feb 2013
Keystone
United States of America
meeting website