Diabetes – New Insights into Mechanism of Disease and Its Treatment

Significance: We are in the midst of an epidemic of type 2 diabetes and the closely related metabolic syndrome. These disorders come from a complete interaction between genes and environment which is not fully understood. The goals of this meeting are to address important new areas of research into the primary pathogenesis of these disorders and especially focus on those that might lead to new therapies. The major topics of the meeting are: Mechanisms of metabolic dysfunction and new therapeutic targets for diabetes and obesity; miRNAs in control of metabolism; Aging, mitochondria, and control of metabolism; Epigenetics and perinatal imprinting in diabetes and obesity; CNS control of metabolism; Gastric bypass surgery and the gut in control of metabolism; Metabolic mediators of insulin resistance; and Signaling defects and inflammation in insulin resistance. The major goals of this meeting are to: 1) Make investigators of aware of important new advances in the field of diabetes research. 2) Bring new topics of research from outside the field to the diabetes research community. 3) Stimulate interactions and potential collaborations between participants. 4) Bring lessons from clinical practice back to the bench. We believe we have identified a program which will bring new scientific knowledge, new methods and new insights from clinical practice together to stimulate interchange of ideas and even collaborations. Although this meeting has been a regular annual event in the Keystone Symposium series, many of the topics and speakers are new and thus will enrich the field in new ways. Innovation: The Diabetes Keystone Symposium remains the most important forum for new basic science presentations in the field of diabetes. By bringing it together with the conference on Adipocyte Biology and have multiple joint sessions, we feel this meeting fill a need in the scientific community that is not filled by other conferences. The meeting has novel content that will inform and challenge the attendees and brings many new research paradigms, as well as novel approaches and methods to this scientific community. The meeting is truly interdisciplinary, with not only basic scientists and clinical scientists, it also includes many disciplines outside the fields of endocrinology and metabolism, including gastroenterology, neuroscience, innate immunity, and genetics.
+ show speakers and program
SUNDAY, JANUARY 27

16:00—20:00
Arrival and Registration

Longs Peak Foyer

MONDAY, JANUARY 28

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—09:00
Welcome and Keynote Address (Joint)
Registered attendees can view abstracts starting on 12/27/2012

Columbine Ballroom
Craig B. Thompson, Memorial Sloan-Kettering Cancer Center, USA
Metabolic Regulation in Cancer Biology

09:00—11:00
Mechanisms of Metabolic Dysfunction and New Therapeutic Targets for Diabetes and Obesity (Joint)
Registered attendees can view abstracts starting on 12/27/2012

Columbine Ballroom
Bruce M. Spiegelman, Harvard Medical School, USA
PPAR Non-Agonists as Anti-Diabetic Therapy

David J. Mangelsdorf, University of Texas Southwestern Medical Center, USA
FGF-19 in Metabolic Control

Michael R. Jirousek, Catabasis Pharmaceuticals, Inc., USA
Dual-Action Anti-Inflammatory Insulin Sensitizers

09:40—10:00
Coffee Break

Longs Peak Foyer
11:00—12:00
APSA Panel on Career Development (Joint)

Columbine Ballroom
Jennifer M. Kwan, University of Illinois, Chicago, USA
APSA, Policy Chair, Vice President External Affairs

11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation


Following Session is for Adipose Tissue Biology (J5)

14:30—16:30
Workshop 1: Measurement of Mitochondrial Function in vitro and in vivo

Quandary Peak
Short Talks Chosen from Abstracts

14:30—16:30
Workshop 1

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for Adipose Tissue Biology (J5)

17:00—19:00
Losing Fat: Dynamics of Adipocyte Lipid Turnover
Registered attendees can view abstracts starting on 12/27/2012

Quandary Peak
Rudolf Zechner, University of Graz, Austria
Molecular Regulation of Lipolysis

Paul F. Pilch, Boston University School of Medicine, USA
Caveolins and Lipolysis

Richard N. Bergman, Cedars-Sinai Medical Center, USA
Physiology: Oscillations in Adipocyte Lipolysis

Short Talk Chosen from Abstracts

17:00—19:00
miRNAs and Metabolic Disease
Registered attendees can view abstracts starting on 12/27/2012

Longs/Grays Peaks
Markus Stoffel, Institute of Molecular Systems Biology, Switzerland
miRNAs in Control of beta-Cell Function

Jens C. Brüning, Institute for Genetics, University of Cologne, Germany
miRNAs in Control of Liver Metabolism

Anna Krook, Karolinska Institutet, Sweden
Role of miRNA Let7 in Diabetes-Related Inflammation

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 1

Colorado Rockies Ballroom

TUESDAY, JANUARY 29

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for Adipose Tissue Biology (J5)

08:00—11:00
Remodeling a Healthy Adipose Tissue
Registered attendees can view abstracts starting on 12/27/2012

Quandary Peak
Silvia Corvera, University of Massachusetts Medical School, USA
Feeding Fat and Vascular Remodeling

Rajat Singh, Albert Einstein College of Medicine, USA
When Fat Is Self-Absorbed – Autophagy and Lipid Metabolism

Chad A. Cowan, Harvard University, USA
Adipocyte Ontogeny and Turnover

Speaker to be Announced

Short Talk(s) Chosen from Abstracts

08:00—11:00
Aging, Mitochondria and Control of Metabolism
Registered attendees can view abstracts starting on 12/27/2012

Longs/Grays Peaks
Andrew G. Dillin, The Salk Institute for Biological Studies, USA
Humoral Control of Mitochondrial Form and Function

Kitt F. Petersen, Yale University School of Medicine, USA
Altered Mitochondrial Function in Muscle in Aging and Disease

Eric M. Verdin, University of California, San Francisco, USA
Reversible Acetylation in Regulation of Mitochondrial Function and Aging

Domenico Accili, Columbia University, USA
Talk Title to be Determined

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer
17:00—19:00
Epigenetics and Perinatal Imprinting in Diabetes and Obesity (Joint)
Registered attendees can view abstracts starting on 12/27/2012

Columbine Ballroom
C. Ronald Kahn, Joslin Diabetes Center and Harvard Medical School, USA
Diabetes and Obesity - Nature versus Nurture

Anne Ferguson-Smith, University of Cambridge, UK
Mechanisms of Genetic Imprinting

Paolo Sassone-Corsi, University of California, Irvine, USA
Epigenetic Control of Circadian Rhythms and Metabolism

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 2

Colorado Rockies Ballroom

WEDNESDAY, JANUARY 30

07:00—08:00
Breakfast

Colorado Rockies Ballroom
08:00—11:00
Signaling Defects and Inflammation in Insulin Resistance (Joint)
Registered attendees can view abstracts starting on 12/27/2012

Columbine Ballroom
Diane J. Mathis, Harvard Medical School, USA
T-Cell Function in Adipose Tissue Depots

Anthony W. Ferrante, Columbia University, USA
Macrophages in Insulin Resistance

Ruslan M. Medzhitov, Yale University School of Medicine, USA
Inflammation and Metabolism

Ajay Chawla, University of California, San Francisco, USA
Innate Control of Metabolism

09:20—09:40
Coffee Break

Longs Peak Foyer
11:00—13:00
Poster Setup

Colorado Rockies Ballroom
13:00—22:00
Poster Viewing

Colorado Rockies Ballroom

On Own for Lunch and Recreation


Following Session is for Adipose Tissue Biology (J5)

14:30—16:30
Workshop 2: Assessing Immune Cell Populations in Adipose Tissue: What Are the FACS?

Quandary Peak
Short Talks Chosen from Abstracts

14:30—16:30
Workshop 2

Short Talks Chosen from Abstracts

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for Adipose Tissue Biology (J5)

17:00—19:00
Variation in the Biology of Adipose Depots
Registered attendees can view abstracts starting on 12/27/2012

Quandary Peak
Susan K. Fried, Boston Medical Center, USA
Genes Regulating Fat Distribution in Men and Women

James L. Kirkland, Mayo Clinic, USA
Cellular Senescence and Adipocyte Tissue

Short Talk Chosen from Abstracts

17:00—19:00
Gastric Bypass Surgery and the Gut in Control of Metabolism
Registered attendees can view abstracts starting on 12/27/2012

Longs/Grays Peaks
David E. Cummings, University of Washington, USA
Metabolic Surgery: Endocrine Mechanisms of Diabetes Remission after "Bariatric" Operations

Jin-Long Chen, NGM Biopharmaceuticals, Inc., USA
New Gut Mediators of Bypass Surgery

Lee M. Kaplan, Massachusetts General Hospital, USA
Physiological Responses to Bariatric Surgery

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
19:30—22:00
Poster Session 3

Colorado Rockies Ballroom

THURSDAY, JANUARY 31

07:00—08:00
Breakfast

Colorado Rockies Ballroom

Following Session is for Adipose Tissue Biology (J5)

08:00—11:00
Brown Adipose Tissue: Where There Is Smoke...
Registered attendees can view abstracts starting on 12/27/2012

Quandary Peak
Stephen R. Farmer, Boston University School of Medicine, USA
Brite Fat-Molecular Mechanisms

Sheila Collins, Sanford-Burnham Medical Research Institute, USA
Converging Hormonal Signals that 'Spark' the Brown-in-White Adipocyte Transformation

Yu-Hua Tseng, Joslin Diabetes Center/Harvard Medical School, USA
Developmental Control of Brown Adipose Tissue

Short Talks Chosen from Abstracts

08:00—11:00
Metabolic Mediators of Insulin Resistance
Registered attendees can view abstracts starting on 12/27/2012

Longs/Grays Peaks
Philipp E. Scherer, University of Texas Southwestern Medical Center at Dallas, USA
Ceramides as Mediators of Insulin Resistance

Gerald I. Shulman, HHMI/Yale University School of Medicine, USA
Novel PKCs as Mediators of Insulin Resistance

Gökhan S. Hotamisligil, Harvard University, USA
ER Stress as a Mediator of Insulin Resistance

Reuben J. Shaw, The Salk Institute, USA
AMPK Signaling Modulates Insulin Resistance

09:00—09:20
Coffee Break

Longs Peak Foyer

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Longs Peak Foyer

Following Session is for Adipose Tissue Biology (J5)

17:00—19:00
Beyond Diabetes - Complications of Obesity
Registered attendees can view abstracts starting on 12/27/2012

Quandary Peak
Kathryn J. Moore, New York University Medical Center, USA
Atherosclerosis and Lipid Metabolism

Mikhail G. Kolonin, University of Texas, USA
Regulation of Tumor Progression by Adipose Tissue

Speaker to be Announced

Short Talk Chosen from Abstracts

17:00—19:00
CNS Control of Metabolism
Registered attendees can view abstracts starting on 12/27/2012

Columbine Ballroom
Joel K. Elmquist, University of Texas Southwestern Medical Center, USA
CNS Control of Energy Balance and Peripheral Metabolism

Christoph Buettner, Mount Sinai School of Medicine, USA
Brain Control of Adipose Tissue Metabolism

Richard M. Caprioli, Vanderbilt University Medical Center, USA
Molecular Imaging of Tissue by Mass Spectrometry: Looking Beyond the Microscope

19:00—20:00
Social Hour w/ Lite Bites

Colorado Rockies Ballroom
20:00—23:00
Entertainment

Colorado Rockies Ballroom

FRIDAY, FEBRUARY 1


Departure


*Session Chair †Speaker invited, not yet responded.

27 Jan - 1 Feb 2013
Keystone
United States of America
meeting website