Noncoding RNAs in Development and Cancer

A recurrent principle in cancer biology is the co-option of pathways that function during development to promote aberrant tumor cell behavior. This principle clearly applies to the roles of noncoding RNAs in cancer. Examples of noncoding RNAs that modify tumor phenotypes include the microRNA (miRNA) let-7, a key regulator of developmental timing in C. elegans, and the miR-17-92 cluster, which conducts essential regulatory functions during mammalian development. However, we currently have only a rudimentary understanding of how diverse classes of noncoding RNAs function in physiologic and pathophysiologic states. This meeting will bring together experts focused on the roles of noncoding RNAs in development and cancer with the broad goals of 1) illuminating new connections between developmental and cancer pathways controlled by miRNAs and long noncoding RNAs; 2) uncovering novel mechanisms by which developmental and cancer pathways influence noncoding RNA processing and activity; 3) revealing the molecular mechanisms through which miRNAs and long noncoding RNAs function in these pathways; and 4) highlighting how our understanding of noncoding RNA-regulated pathways can be applied in the development of novel therapeutic strategies for cancer and perhaps other diseases. To accomplish these goals, this meeting will bring together experts from disparate fields ranging from organismal-level developmental and cancer biology to biochemical and molecular studies of RNA function to share their newest data and ideas. It is anticipated that the diverse views, approaches, and results presented by participants will foster new lines of investigation and collaborations which will be critical to dissect the myriad functions of noncoding RNAs in health and disease.
+ show speakers and program

SUNDAY, JANUARY 20

15:00—19:30
Arrival and Registration

18:15—19:15
Refreshments

19:15—21:30
Welcome and Keynote Session
Registered attendees can view abstracts starting on 12/20/2012

Jeannie T. Lee, Massachusetts General Hospital, USA
X-Chromosome Inactivation as a Model for Regulation by Long Noncoding RNA

V. Narry Kim, Seoul National University, South Korea
miRNA Processing and Mechanism


MONDAY, JANUARY 21

07:00—08:00
Breakfast

08:00—11:00
MicroRNAs in Development
Registered attendees can view abstracts starting on 12/20/2012

Victor R. Ambros, University of Massachusetts, USA
miRNAs in Developmental Timing

Antonio J. Giraldez, Yale University, School of Medicine, USA
miRNAs in Zebrafish Development

Eric N. Olson, University of Texas Southwestern Medical Center at Dallas, USA
miRNAs in Cardiac Development and Disease

Andrea Ventura, Memorial Sloan-Kettering Cancer Center, USA
miRNAs in Mammalian Development and Disease

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Mechanisms of Small RNA Functions
Registered attendees can view abstracts starting on 12/20/2012

Phillip A. Sharp, Massachusetts Institute of Technology, USA
Regulation and Function of Small RNA Pathways

Judy Lieberman, Immune Disease Institute, USA
A Systems Approach to Understanding Gene Networks Regulated by Oncomirs

Irene Bozzoni, University La Sapienza, Rome, Italy
Regulation of miRNA Function by Competing Endogenous RNAs

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 1


TUESDAY, JANUARY 22

07:00—08:00
Breakfast

08:00—11:00
Long Noncoding RNAs in Development
Registered attendees can view abstracts starting on 12/20/2012

Peter Fraser, Babraham Institute, UK
LncRNA and Higher-Order Chromatin and Chromosome Structure

Caroline Dean, John Innes Centre, UK
LncRNAs and Flowering Control in Plants

Geneviève Almouzni, Centre National de la Recherche Scientifique, France
LncRNA and Centrometric Heterochromatin

Kathrin Plath, University of California, Los Angeles, USA
X Inactivation and Reactivation in Induced Pluripotency

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
Small RNAs in Pluripotent Cells
Registered attendees can view abstracts starting on 12/20/2012

Gregory J. Hannon, Cold Spring Harbor Laboratory, USA
Talk Title to be Determined

Robert H. Blelloch, University of California, San Francisco, USA
Small RNA Regulation of Pluripotency

George Q. Daley, Children's Hospital Boston, USA
Lin28 in Development and Disease

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 2


WEDNESDAY, JANUARY 23

07:00—08:00
Breakfast

08:00—11:00
MicroRNAs in Cancer
Registered attendees can view abstracts starting on 12/20/2012

Tyler Jacks, Massachusetts Institute of Technology, USA
miRNA Expression and Function in Cancer

Joshua T. Mendell, University of Texas Southwestern Medical Center, USA
miRNAs in Cancer Signaling Pathways

Frank J. Slack, Yale University, USA
miRNAs as Oncogenes and Tumor Suppressors

Chang-Zheng Chen, Stanford University, USA
miRNAs in Lymphocytes and Leukemias

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

13:00—22:00
Poster Viewing


On Own for Lunch and Recreation

14:30—16:30
Workshop: Therapeutic Applications of Noncoding RNAs

Sakari Kauppinen, Santaris Pharma A/S, Denmark
LNA Based Anti-miRNA Therapeutics

Eric G. Marcusson, Regulus Therapeutics, USA
Discovery and Development of Anti-miRNA Therapeutics

Andreas G. Bader, Mirna Therapeutics Inc., USA
miRNA Replacement Therapy

Eva van Rooij, miRagen Therapeutics, USA
Targeting miRNAs in Cardiovascular Disease

16:30—17:00
Coffee Available

17:00—19:00
Processing of Noncoding RNAs
Registered attendees can view abstracts starting on 12/20/2012

Manel Esteller, IDIBELL, Spain
Mechanisms of Altered miRNA Processing in Cancer

Richard Iain Gregory, Harvard Medical School, Children's Hospital, USA
Regulation of miRNA Processing by Lin28

Alexei A. Aravin, California Institute of Technology, USA
Regulation of piRNA Processing

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

19:30—22:00
Poster Session 3


THURSDAY, JANUARY 24

07:00—08:00
Breakfast

08:00—11:00
Long Noncoding RNAs in Cancer
Registered attendees can view abstracts starting on 12/20/2012

Howard Y. Chang, Stanford University, USA
Long Noncoding RNAs and Cancer Progression

Arul M. Chinnaiyan, University of Michigan, USA
LncRNAs Discovery and Use as Noninvasive Biomarkers in Prostate Cancer

John S. Mattick, Garvan Institute of Medical Research, Australia
The Role of Regulatory RNA in Human Development

Michael G. Rosenfeld, HHMI/University of California, San Diego, USA
Moving Stories about lncRNA

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available

17:00—19:00
ncRNAs in Transcriptional Control and Chromatin
Registered attendees can view abstracts starting on 12/20/2012

Antonin Morillon, Institut Curie, France
Yeast Cryptic ncRNAs and Chromatin Regulation

Gary Felsenfeld, NIDDK, National Institutes of Health, USA
ncRNA and Organization of Chromatin Domains

Shiv I. S. Grewal, NCI, National Institutes of Health, USA
The RNAi Pathway in Chromatin Regulation

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

20:00—23:00
Entertainment


FRIDAY, JANUARY 25


Departure


*Session Chair †Speaker invited, not yet responded.

20 Jan - 25 Jan 2013
Vancouver
Canada
meeting website