Frontiers of NMR in Biology

Nuclear magnetic resonance (NMR) spectroscopy has become an important technology in molecular biology and is widely used for elucidating biological mechanisms. It can provide structural information similar and complementary to X-ray crystallography, electron microscopy, mass spectroscopy and small angle scattering methods. However, NMR can also provide unique insights not obtainable otherwise, such as ones involving weak interactions, enzyme reactions or dynamic states. Thus, the focus of the field is expanding from structure determination to macromolecular interactions, posttranslational modifications, functional studies and drug discovery. Unexpected new technologies are constantly emerging suitable to provide new biological insights. Thus, this meeting will include sessions on new enabling technologies and applications to large and challenging systems. Topics will also include membrane protein structures, protein/nucleotide complexes and systems of high biological significance. The symposium will also include presentations on structure-derived function, posttranslational modifications studied in whole cells or cell extracts, and drug discovery. The overall goal of the meeting will be to examine recent technological developments and to demonstrate state-of-the-art applications that yield new understanding of biological mechanisms.
+ show speakers and program
SUNDAY, JANUARY 13

16:00—20:00
Arrival and Registration

Ballroom Lobby

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Michael F. Summers, HHMI/University of Maryland Baltimore County, USA
NMR Methods for Large RNAs and the Mechanism of HIV-1 Genome Packaging

09:00—12:00
New Methods in Solid State NMR
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Beat H. Meier, ETH Zurich, Switzerland
Amyloid Structures by Solid State NMR

Tatyana Polenova, University of Delaware, USA
Magic Angle Spinning Studies of HIV-1 Protein Assemblies

Bernd Reif, Technische Universität München, Germany
Deuteration in and 1H Detection in Solid State NMR

Chad M. Rienstra, University of Illinois at Urbana-Champaign, USA
High-Resolution Protein Structures by Magic-Angle Spinning NMR

Short Talk Chosen from Abstracts

09:40—10:00
Coffee Break

Ballroom Lobby
12:00—13:00
Poster Setup

Superior/Superior Lobby
13:00—22:00
Poster Viewing

Superior/Superior Lobby

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
NMR in Cells and Cell Extracts
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Philipp Selenko, FMP Berlin, Germany
Real-Time Characterization of Posttranslational Protein Modifications in Cellular Environments

Masahiro Shirakawa, Kyoto University, Japan
In-Cell NMR Spectroscopy of Proteins Inside Living Cells

Teresa Fan, University of Louisville, USA
Metabolite Flux Measurements in Living Cells

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Superior/Superior Lobby
19:30—22:00
Poster Session 1

Superior/Superior Lobby

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Elucidating Protein Structure and Function
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Kevin H. Gardner, University of Texas Southwestern Medical Center, USA
Mechanisms of Hypoxic Gene Activation

Mitsuhiko Ikura, Ontario Cancer Institute, Canada
IP3 Receptor Binding and Channel Gating

Angela M. Gronenborn, University of Pittsburgh, USA
HIV Cellular Protein Interactions

Katherine A. Henzler-Wildman, Washington University, USA
Asymmetry and Exchange in the Mechanism of Multidrug Efflux by EmrE

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby
13:00—22:00
Poster Viewing

Superior/Superior Lobby

On Own for Lunch and Recreation

14:30—16:30
Workshop: Protein and RNA Production and Labeling

Ballroom 2-3
16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Nucleotides and Nucleotide/Protein Complexes
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Juli Feigon, University of California, Los Angeles, USA
The Architecture of Telomerase

Walter J. Chazin, Vanderbilt University, USA
Structure and Dynamics of Integrated DNA Replication, Damage Response and Repair Machinery

Michael J. Sattler, Technische Universität München & Helmholtz Zentrum München, Germany
Protein-Nucleic Acid Interactions in Splicing

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Superior/Superior Lobby
19:30—22:00
Poster Session 2

Superior/Superior Lobby

WEDNESDAY, JANUARY 16

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Membrane Proteins
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
James Jeiwen Chou, Harvard Medical School, USA
Structure and Mechanism of Mitochondrial Carriers

Linda Columbus, University of Virginia, USA
Structure, Folding and Functional Studies of Opacity-Associated (Opa) Proteins from Neisseria gonorrhoeae

Marc Baldus, Utrecht University, Netherlands
Characterization of Membrane Proteins in the Solid State

Senyon Choe, The Salk Institute, USA
Facile NMR Structure Determination of Human Membrane Proteins

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Ballroom Lobby
11:00—13:00
Poster Setup

Superior/Superior Lobby
13:00—22:00
Poster Viewing

Superior/Superior Lobby

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Drug Targets, NMR in Industry
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Stephen W. Fesik, Vanderbilt University School of Medicine, USA
NMR-Based Drug Discovery in Academia

Daniel F. Wyss, Merck & Co., Inc., USA
FBDD on a Tough Target Starts to Yield – Discovery of Orally Active, Brain-Penetrant BACE1 Inhibitors

Teresa Carlomagno, EMBL Heidelberg, Germany
NMR-Based Drug Discovery Methods in Academia

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Superior/Superior Lobby
19:30—22:00
Poster Session 3

Superior/Superior Lobby

THURSDAY, JANUARY 17

07:00—08:00
Breakfast

Golden Cliff/Eagles
08:00—11:00
Solution NMR Methods
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Ad Bax, NIDDK, National Institutes of Health, USA
Structures from Chemical Shifts and Databases

Gerhard Wagner, Harvard Medical School, USA
New NMR Experiments for Challenging Proteins

Gottfried Otting, Australian National University, Australia
Paramagnetic Probes for NMR Studies

Bernhard Brutscher, Institut de Biologie Structurale, France
Fast Methods in Biological NMR

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Ballroom Lobby

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Ballroom Lobby
17:00—19:00
Folding and Disease
Registered attendees can view abstracts starting on 12/13/2012

Ballroom 2-3
Ichio Shimada, University of Tokyo, Japan
Functional Analyses of Membrane Proteins

Robert Tycko, National Institutes of Health, USA
Amyloid Fibril Structures, in vitro and in vivo

Kurt Wüthrich, ETH Zürich /The Scripps Research Institute, Switzerland
NMR and PSI Projects on Soluble and Membrane Proteins

19:00—20:00
Social Hour w/ Lite Bites

Ballroom 2-3
20:00—23:00
Entertainment

Ballroom 2-3

FRIDAY, JANUARY 18


Departure


*Session Chair †Speaker invited, not yet responded.

13 Jan - 18 Jan 2013
Snowbird
United States of America
meeting website