Multiple Sclerosis

Multiple sclerosis (MS) is a complex disease in which genetic, environmental and stochastic factors all play a part to induce aberrant interactions between the immune system and neural cells, ultimately transforming into progressive neurological disability. Our understanding of MS is rapidly evolving and multiple areas of research are showing great promise of future treatment or cure. However, further progress will depend on establishing a deep understanding of the underlying disease mechanisms. With this in mind, this meeting aims to: 1) define integrated approaches by which to study disease pathogenesis, which represents a critical barrier to progress in the field; 2) provide an up to date perspective on molecular pathogenesis and how this might be used to optimize patient management; 3) define state of the art technologies by which to quantitate disease burden; 4) discuss key elements concerning the concept of disease heterogeneity and how emergent approaches to disease stratification can optimize management strategies; and 5) provide perspectives concerning the potential therapeutic applications of neuroprotective, regenerative and bioengineering based strategies, and how these might complement immunotherapy. Speakers have been carefully selected on the basis that, independent of whether they are basic scientists or clinician researchers, they each have a track record in adopting a multi-disciplinary approach that has enabled the application of discoveries in one area of endeavor to seed advances in another. We anticipate that participants will gain an understanding of how a systems biology based approach can accelerate our knowledge base of multiple sclerosis and how that knowledge base can be successfully applied to novel clinical research and development, as well as potentiated patient care.
+ show speakers and program
FRIDAY, JANUARY 11

16:00—20:00
Arrival and Registration

Lower Atrium

SATURDAY, JANUARY 12

07:00—08:00
Breakfast

Gallatin
08:00—09:00
Welcome and Keynote Address
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
* Trevor J. Kilpatrick, University of Melbourne, Australia

Lawrence Steinman, Beckman Center for Molecular Medicine, Stanford University, USA
An Integrated and Evolutionary Perspective to Understanding the Pathogenesis of MS

09:00—23:15
Nature and Nurture: Insights Beyond GWAS and Epidemiological Studies
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
Sreeram Ramagopalan, University of Oxford, UK
Implications of Epigenetic Changes in MS

Justin Rubio, GlaxoSmithKline, UK
Keys to Realizing the Promise of Pharmacogenomics

Speaker to be Announced

Short Talk(s) Chosen from Abstracts

09:40—10:00
Coffee Break

Lower Atrium
11:15—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Cellular and Molecular Profiling: The Road to an Integrated Approach
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
* Hartmut Wekerle, Max Planck Institut, Germany
Lessons from Pathology

William H. Robinson, Stanford School of Medicine, USA
From Tissue to Proteomics and Lipidomics

Ronald N. Germain, NIAID, National Institutes of Health, USA
A Systems Biology Perspective to Autoimmunity

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Gallatin
19:30—22:00
Poster Session 1

Gallatin

SUNDAY, JANUARY 13

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Paraclinical Measures of Structural and Functional Change
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
Elliot Frohman, University of Texas Southwestern Medical Center at Dallas, USA
Eye-ing a Window of Neuroprotection in the Visual System for Multiple Sclerosis

John Gore, Vanderbilt University, USA
Recent Developments in MRI

Speaker to be Announced

Martin Kerschensteiner, Ludwig-Maximilians-University Munich, Germany
Harnessing the Potential of Cellular and Molecular in vivo Imaging

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Immunopathogenesis
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
* Jingwu Zhang Zang, GlaxoSmithKline, China

Marc Veldhoen, Babraham Institute, UK
The Molecular Control of Immune Homeostasis

Stephen M. Anderton, University of Edinburgh, UK
Immune-Mediated Auto-Aggression and Regulation

Takashi Yamamura, National Institute of Neuroscience, NCNP, Japan
Interrogating Innate Immunity and Key Environmental Interactions

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Gallatin
19:30—22:00
Poster Session 2

Gallatin

MONDAY, JANUARY 14

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Clinical Controversies
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
Helen Tremlett, University of British Columbia, Canada
Emerging Concepts of Disease Heterogeneity in MS

Timothy Coetzee, National Multiple Sclerosis Society, USA
Lessons from CCSVI

Jun-ichi Kira, Kyushu University, Japan
Dissecting the Interface between NMO and MS

* Brenda Banwell, University of Pennsylvania, USA
Negotiating between ADEM, CIS and MS: An Age-Specific Roadmap?

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

Lower Atrium
11:00—13:00
Poster Setup

Gallatin
13:00—22:00
Poster Viewing

Gallatin

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Clinical Developments
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
Richard K. Burt, Northwestern University, USA
Hematopoietic Stem Cell Transplantation for Multiple Sclerosis

Jingwu Zhang Zang, GlaxoSmithKline, China
Optimizing Translational Research Pipelines in MS

Richard A. Rudick, Cleveland Clinic Foundation, USA
Design Issues for Progressive MS Clinical Trials

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Gallatin
19:30—22:00
Poster Session 3

Gallatin

TUESDAY, JANUARY 15

07:00—08:00
Breakfast

Gallatin
08:00—11:00
Neurobiology
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
* Trevor J. Kilpatrick, University of Melbourne, Australia

Peter K. Stys, University of Calgary, Canada
Axon-Glial Interactions

Ben Emery, University of Melbourne, Australia
Molecular Determinants of Myelination

Catherine Lubetzki, INSERM and UPMC, France
Translational Approaches to Remyelination

Frauke Zipp, Johannes-Gutenberg-Universität Mainz, Germany
Crosstalk of the Immune System and the Nervous System

Short Talk(s) Chosen from Abstracts

09:00—09:20
Coffee Break

Lower Atrium

On Own for Lunch and Recreation

16:30—17:00
Coffee Available

Lower Atrium
17:00—19:00
Repair
Registered attendees can view abstracts starting on 12/11/2012

Jefferson/Madison
* Catherine Lubetzki, INSERM and UPMC, France

Gianvito Martino, San Raffaele Scientific Institute, Italy
The Role of Neural Stem Cells in Brain Regeneration

Trevor J. Kilpatrick, University of Melbourne, Australia
Targeting the Oligodendrocyte Lineage

Amit Bar-Or, Montreal Neurological Institute, Canada
Talk Title to be Determined

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Gallatin
20:00—23:00
Entertainment

Gallatin

WEDNESDAY, JANUARY 16


Departure


*Session Chair †Speaker invited, not yet responded.

11 Jan - 16 Jan 2013
Big Sky
United States of America
meeting website