Pathogenic Processes in Asthma and COPD

Chronic obstructive pulmonary disease (COPD) and asthma continue to be important causes of morbidity, mortality, and health-care costs worldwide. However, the underlying causes of asthma and COPD remain poorly understood, even as the incidence of such diseases continues to increase. Recent discoveries have uncovered strong associations between both lung function and immune responses in early life and the subsequent development of persistent asthma and chronic airway obstruction in adulthood. However, to date, no meeting has taken advantage of these recent discoveries. The overall goal of this meeting is to draw together investigators from multiple disciplines doing work relevant to understanding the genetic, epigenetic and environmental factors and mechanisms that affect the development of asthma and COPD. The specific goals of the meeting are to: 1) explore recent insights into the genetic and epigenetic origins of asthma and COPD; 2) understand the relationship between early life environmental exposures and impaired lung function throughout life; 3) understand the relationship between lung infections as well as changes in the intestinal microbiome and the development of chronic lung diseases; 4) understand the role of newly described innate immune cell populations and pathways in the development of lung inflammation; 5) understand recent insights into the mechanisms of lung development, repair and remodeling; and 6) explore unique pathways of resolution of lung inflammation. By bringing together a critical mass of multidisciplinary researchers, this symposium should provide an ideal forum for exploring novel prevention and treatment strategies for these chronic respiratory diseases based on the identification of the genetic and environmental factors that interactively cause these disorders. Moreover, this meeting will serve to provide an in-depth exposure of junior investigators (graduate students and post-docs) to a fast-moving, fruitful area of medical research, as well as enticing such scientists into the field. Opportunities for interdisciplinary interactions will be significantly enhanced by the concurrent meeting on Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology, which will share a keynote address and two plenary sessions with this meeting.
+ show speakers and program

THURSDAY, JANUARY 10

15:00—19:30
Arrival and Registration

Sweeney Ballroom Foyer
18:15—19:15
Refreshments

Sweeney F, Main Level Breakouts
19:15—20:30
Welcome and Keynote Address (Joint)
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-E
Bart N. Lambrecht, Ghent University, Belgium
The Dendritic Cell Network and the Response to Allergens


FRIDAY, JANUARY 11

07:00—08:00
Breakfast

Sweeney F, Main Level Breakouts

Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

08:00—11:00
Adaptations to Chronic Helminth Infection
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Fred D. Finkelman, University of Cincinnati, USA
Overview of Adaptations to Intestinal Helminths

Maria Yazdanbakhsh, Leiden University Medical Center, Netherlands
Parasitic Helminths and the Human Immune Response

Ajay Chawla, University of California, San Francisco, USA
Metabolic Consequences of Type 2 Immunity

Speaker to be Announced

Short Talk(s) Chosen from Abstracts

08:00—11:00
New Insights into the Pathogenesis of Lung Diseases
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
Sally E. Wenzel, University of Pittsburgh, USA
Emerging Concepts on the Heterogeneity of Asthma

Fernando D. Martinez, University of Arizona, USA
Early-Life Origins of Chronic Obstructive Pulmonary Disease

Avrum Spira, Boston University, USA
Molecular Insights into COPD via Transcriptomic Profiling

Ian M. Adcock, Imperial College London, UK
Epigenetic Regulation of Lung Diseases

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available


Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

17:00—19:00
Regulating the Type 2 Cytokines
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Dirk E. Smith, Amgen Inc., USA
The Role of IL-33 in Regulating Innate Airway Inflammation

Steven F. Ziegler, Benaroya Research Institute and University of Washington School of Medicine, USA
TSLP in the Regulation of Type 2 Immunity

Richard M. Maizels, University of Edinburgh, UK
Coaptation of the Host Immune Response by Parasitic Helminths

Short Talk Chosen from Abstracts

17:00—19:00
Infectious Origins of Lung Disease
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
James E. Gern, University of Wisconsin, USA
Virus Infections and Asthma Inception and Exacerbation

Sebastian L. Johnston, Imperial College London, UK
Mechanisms of Rhinovirus-Induced Exacerbations in Asthma and COPD

Michael J. Holtzman, Washington University, USA
Immune Pathways Translating Viral Infection into Chronic Airway Disease

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 1

Sweeney F, Main Level Breakouts

SATURDAY, JANUARY 12

07:00—08:00
Breakfast

08:00—11:00
Innate Helper Cells in Type 2 Immunity (Joint)
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-E
Andrew N.J. McKenzie, Medical Research Council, UK
Nuocytes, IL-33 and Lung Inflammation

Hergen Spits, University of Amsterdam, Netherlands
The Spectrum of Human Innate Lymphoid Cells

Richard M. Locksley, University of California, San Francisco, USA
Function-Marking Innate Helper Type 2 Cells

Shigeo Koyasu, Keio University School of Medicine, Japan
Type 2 Innate Immune Responses and the Natural Helper Cell

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available


Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

17:00—19:00
Adaptive Th2 and TFH Cells
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Speakers to be Announced

K. Mark Ansel, University of California San Francisco
MicroRNA Regulation of Tfh and Th2 Cell Development

Shane Crotty, La Jolla Institute for Allergy and Immunology, USA
Th2 - Tfh Cell Determinants

Short Talk Chosen from Abstracts

17:00—19:00
Role of Th17 Cells in the Regulation of Lung Immunity
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
Jay K. Kolls, University of Pittsburgh School of Medicine, USA
Th17 Cells as Critical Regulators of Host Immunity to Bacterial and Fungal Infections at Mucosal Surfaces

Susan V. Lynch, University of California, San Francisco, USA
Airway Microbiota and Lung Disease

Marsha Wills-Karp, Johns Hopkins Bloomberg School of Public Health, USA
Microbiota Regulation of Th17-Mediated Severe Asthma

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 2

Sweeney F, Main Level Breakouts

SUNDAY, JANUARY 13

07:00—08:00
Breakfast


Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

08:00—11:00
Commensals, Immunity and Epithelial Homeostasis
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Speaker to be Announced

Wenjun Ouyang, Genentech, Inc., USA
The IL-10/22 Family of Cytokines in Epithelial Health

Yasmine Belkaid, NIAID, National Institutes of Health, USA
Parasites and the Commensal Flora

Sabine Eming, University of Cologne, Germany
Tissue Repair and Type 2 Immunity

Short Talk(s) Chosen from Abstracts

08:00—11:00
Lung Development, Repair and Remodeling
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
Jeffrey A. Whitsett, Cincinnati Children's Hospital Medical Center, USA
Transcriptional Networks Linking Mucus Metaplasia and Innate Immunity in the Respiratory Epithelium

Paul W. Noble, Duke University, USA
Matrix Regulation of Lung Injury, Inflammation and Repair

Darryl Knight, University of British Columbia, Canada
Stem Cells for Repair of the Airways

Joanne L. Wright, University of British Columbia, Canada
Cigarette Smoke Induced COPD - Use of Animal Models

Short Talk(s) Chosen from Abstracts

09:20—09:40
Coffee Break

11:00—13:00
Poster Setup

Sweeney F, Main Level Breakouts
13:00—22:00
Poster Viewing

Sweeney F, Main Level Breakouts

On Own for Lunch and Recreation

16:30—17:00
Coffee Available


Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

17:00—19:00
Myeloid Cells in Tissue Homeostasis
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Judith E. Allen, University of Edinburgh, UK
AAMs

David Voehringer, University Hospital of Erlangen, Germany
Eosinophils - What Have We Learned?

Hajime Karasuyama, Tokyo Medical and Dental University, Japan
Basophils - Innate Cells Regulated by the Adaptive Response

Short Talk Chosen from Abstracts

17:00—19:00
Mechanisms of Chronic Obstructive Pulmonary Disease
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
Shyam Biswal, Johns Hopkins School of Public Health, USA
Oxidative Stress Regulation of Lung Inflammation in COPD

Augustine Choi, Harvard Medical School, USA
Regulation and Function of Autophagy in COPD

Farrah Kheradmand, Baylor College of Medicine, USA
Autoreactive T Cells in the Pathophysiology of Human and Mouse Emphysema

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
19:30—22:00
Poster Session 3

Sweeney F, Main Level Breakouts

MONDAY, JANUARY 14

07:00—08:00
Breakfast

08:00—11:00
Initiating Type 2 Immunity (Joint)
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-E
Jean-Philippe Girard, CNRS, France
IL-33 Processing and Activation by Inflammatory Proteases

Jenny P. Ting, University of North Carolina at Chapel Hill, USA
Uric Acid and the Inflammasome

Marco Idzko, University Hospital Freiburg, Germany
ATP and P2X Receptors in Type 2 Immunity

Jack A. Elias, Yale School of Medicine, USA
Chitin and Chitinases

09:00—09:20
Coffee Break


On Own for Lunch and Recreation

16:30—17:00
Coffee Available


Following Session is for Type 2 Immunity: Initiation, Maintenance, Homeostasis and Pathology (J1)

17:00—19:00
Pathologic Syndromes
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom A-B
Stuart G. Tangye, Garvan Institute of Medical Research, Australia
Lymphocyte Defects in Hyper IgE Syndromes

Thomas A. Wynn, NIAID, National Institutes of Health, USA
Pathogenesis of Type 2 Immunity

Lawren C. Wu, Genentech, Inc., USA
Therapeutic Targeting of IgE-Switched Cells in Asthma

Short Talk Chosen from Abstracts

17:00—19:00
Therapeutic Opportunities in Asthma and COPD
Registered attendees can view abstracts starting on 12/10/2012

Sweeney Ballroom C-E
Ruth Tal-Singer, GlaxoSmithKline, USA
Challenges and Opportunities in COPD Drug Development

John G. Matthews, Genentech, Inc., USA
Anti-IL-13 Therapy in Asthma

Alison L. Budelsky, Amgen Inc., USA
Blockade of IL-17RA in Asthma

Short Talk Chosen from Abstracts

19:00—20:00
Social Hour w/ Lite Bites

Sweeney F, Main Level Breakouts
20:00—23:00
Entertainment

Sweeney F, Main Level Breakouts

TUESDAY, JANUARY 15


Departure


*Session Chair †Speaker invited, not yet responded.

10 Jan - 15 Jan 2013
Santa Fe
United States of America
meeting website