Vth International Conference on Molecular Mechanisms of Fungal Cell Wall Biogenesis

Dear Colleagues,

It is my great pleasure to invite you on behalf of the Organizing Committee to the Vth International Conference on Molecular Mechanisms of Fungal Cell Wall Biogenesis (FCWB2012) which will take place on June 6th - 9th, 2012 in a small touristic place Primošten in the central part of the Croatian Adriatic coast.

The meeting with the intention to gather life scientists of different profiles dealing with biosynthesis, secretion, structural and functional modifications and incorporation of different fungal cell wall components in a complex, sophisticated "outermost cellular compartment", has become a tradition since the first meeting organized in Ascona, Switzerland in 2001.
+ show speakers and program
Speakers
Markus Aebi

Markus Aebi The research of Markus Aebi focuses on the molecular concepts of N-linked protein glycosylation and the functional role of this process in fungal cell wall biogenesis. In addition, the interaction of fungi with predators and parasites is a major interest of his group.
Charles Boone

Howard Bussey

Neta Dean

Neta Dean Protein glycosylation is an essential modification that functions in many biological roles ranging from the stabilization of protein structure to the regulation of cell surface properties. Our research aims to understand how this modification is regulated, how glycoproteins mediate their biological roles at the cell surface, and how cell wall biosynthesis is coordinated with growth and division. As a model system for these studies, we use the budding yeast S. cerevisiae so that we can apply a combined genetic, biochemical, and cell biological approach to address these problems. Since cell surface carbohydrates are among the most important virulence determinants of pathogenic fungi, a major effort is also underway to understand the regulation of cell surface glycoprotein synthesis in the human fungal pathogen, Candida albicans.
Niel Gow

Niel Gow I graduated with a B.Sc. from Edinburgh University and a Ph.D. from Aberdeen University. I was a research fellow in Denver, before returning to Aberdeen as a faculty member in 1984. I am a founding member of the Aberdeen Fungal Group that constitutes one of the largest academic centres for medical mycology in the world. My research is focussed on: (i) the molecular genetics of cell wall biosynthesis in pathogenic fungi - in particular the genetics of glycosylation and the fungus-host interaction in relation to immune recognition and function, (ii) the genetics of chitin synthesis and the response to antifungal agents; (iii) directional growth responses of fungal cells; (iv) the virulence properties of medically important fungal species; (v) the evolution, genome biology and genotyping of Candida species. I have published over 250 research papers and reviews in these areas.
Sarah Gurr

Jean-Marie Francois

Jean-Marie Francois Jean Marie Francois' Laboratory research activities follows three major lines: characterization of the cell wall remodelling by a global transcriptomic approach using various drugs and time course experiments; identifying the function of Knr4/Smi1 in the Pkc1-MAP kinase pathway and how this protein can modulate the connection between cell wall synthesis and cell growth and identifying the precise connection between Slt2 phosphorylation and activation of Rlm1.
Frans Klis

Frans Klis Candida albicans is an opportunistic pathogenic fungus that inhabits the mucosal layers of the human body but can cause fatal systemic infections when the immune system deteriorates. Its walls are covered by a dense coat of 20-30 different covalently linked proteins, which interact with host cells and help to counteract various forms of environmental stress. In our studies we focus on: (1) characterization and regulation of the wall proteome under infection-related stress conditions; (2) functions of individual wall proteins; (3) identification of vaccine antigens based on wall proteins, and (4) identification of diagnostic markers based on secretome proteins.
James B. Konopka

James B. Konopka James Konopka’s lab studies the mechanisms of fungal pathogenesis with an emphasis on the regulation of plasma membrane function. Their recent studies on the role of the MCC/eisosome subdomains of the plasma membrane in Candida albicans have shown that these immobile punctate domains regulate many functions related to virulence,including resistance to stress, morphogenesis, and cell wall synthesis. Recent results will be presented at the conference describing the role of specific MCC/eisosome proteins, such as Sur7 and Nce102, in the spatial regulation of cell wall synthesis and the chemical composition of the cell wall.
Anant K. Menon

Anant K. Menon I am interested in the biogenesis of cellular membranes. Research in my laboratory focuses on understanding how lipids are transported across the membrane bilayer and between different membranes in cells. These transport events are critical in a variety of contexts ranging from membrane bilayer expansion, protein N-glycosylation and GPI anchoring, to the visual cycle and processing of lipoprotein-derived cholesterol.
Yoshikazu Ohya

Ohya Yoshikazu My current research is on biosynthesis and assembly of 1,3-beta-glucan, cell wall integrity checkpoint, and system biology based on cell imaging. I received my PhD in Plant Sciences from the University of Tokyo in 1988, and studied calmodulin in the laboratory of David Botstein (Stanford University). I have been a Professor at the Department of Integrated Biosciences, Graduate School of Frontier Sciences, the University of Tokyo since 1999. I have run the marathon 7 times.
Laura Popolo

Laura Popolo Laura Popolo’s main research interests are: morphogenic development and cell wall biogenesis/regulation in fungi, GAS and PHR families of glucan remodeling enzymes, cell wall stress response, biosynthetic pathway and biochemical characterization of Gas/Phr enzyme family.
Terry Roemer

Caesar Roncero

Caesar Roncero The work in my Lab has been focused for many years in the mechanisms controlling how chitin synthesis is regulated in yeast during cell cycle or under stressful conditions. In this scenario our work has derived lately in the study of the molecular mechanisms that control the intracellular trafficking of yeast major Chitin Synthase, Chs3. Our recent interest is thus focused in understanding how Chs3 oligomerizes at the ER, how Chs3 is polarizelly delivered to the neck and how Chs3 is endocytically recycled and how all of them co-ordinately regulate chitin synthase activity. Our studies try to decipher the molecular domains along the Chs3 protein that dictate its intracellular behaviour but also the role that other accessory proteins play on it. In sum, we are working in the cellular and molecular mechanisms that guarantee the correct assembly of the chitin ring allowing proper morphogenesis of a yeast cell.
Francois Routier

Françoise Routier The research interest of Prof. Françoise Routier and her group lies in the biosynthesis and function of carbohydrates in the eukaryotic pathogen Leishmania major and Aspergillus fumigatus, with a focus on potential drug targets. One of our current centres of attention is the biosynthetic pathway of the fungal polysaccharide galactomannan and its importance in growth.
Gero Steinberg

Gero Steinberg I am interested in intracellular transport processes and how these organize the fungal cell. Most recently my research group has focussed on the cooperation of motor proteins in the secretion of chitin synthases and in early endosome motility. Our work provides insight in the role of the cytoskeleton in cellular organization, polarized growth and pathogenic development in fungi.
Sabine Strahl

Widmar Tanner

Widmar Tanner My present field is the study of lateral compartmentation of yeast plasma membranes. The composition of certain stable membrane microdomains is dependent on the membrane potential. At the same time the sensitivity of the cells towards detergents and polyene antimycotics changes dramatically with depolarizing the cells. What is the molecular reason for this?
Han Wösten

Han Wösten My work focusses on growth and development of fungi. We particularly focus on heterogeneity in the vegetative mycelium and formation of reproductive structures such as mushrooms and conidiophores. In the case of reproductive structures, we focus on regulatory mechanisms and the role of cell wall proteins.
Koji Yoda

Koji Yoda Our lab is interested in molecular mechanisms of intracellular localization of proteins, lipids and carbohydrates especially via the ER and Golgi. We are also interested in biosynthesis of these organelles and the cell wall in the yeast Saccharomyces cerevisiea.

6 Jun - 9 Jun 2012
Primosten
Croatia (Hrvatska)
meeting website