Machines on genes II - The central dogma at the interface of biology, chemistry and physics

The conference will cover topics in DNA replication, recombination, repair and transcription and will showcase the latest work of world leaders in the fields of structural biology, chemical biology and novel biophysical methods including single-molecule detection.

Topics:
Mechanisms of DNA/RNA motor proteins
Biochemical and biophysical analysis of DNA:protein interactions
New mechanistic insights into DNA replication, recombination, repair and transcription
Architecture of multi-protein machines involved in complex DNA/RNA transactions
Application of new biophysical methods including single molecule detection
+ show speakers and program
arly Career Research Award
Structural studies of the type IV secretion system
Vidya Chandran (Indian Institute of Science, India)
Speakers:
Anna Marie Pyle (Yale University, U.S.A.)
Single-molecule studies of DNA replication
Antoine van Oijen (Groningen University, Netherlands)
Molecular machines of DNA break repair: what they look like and how they work
Claire Wyman (Erasmus MC, The Netherlands)
Nucleotide-driven conformational changes in gyrase and reverse gyrase couple the nucleotide cycle to strand passage and DNA supercoiling
Dagmar Klostermeier (University of Muenster, Germany)
Structure and mechanism of the INO80 chromatin remodelling complex
Dale Wigley (The Institute of Cancer Research, United Kingdom)
Watching the action of gene machines one at a time
David Sherratt (University of Oxford, United Kingdom)
Quantifying how DNA stretches, melts and changes twist under tension
Gijs Wuite (VU University Amsterdam , Netherlands)
Single molecule studies of eukaryotic transcription
Jens Michaelis (Ludwig-Maximilians-Universität München , Germany)
The mechanism of phiC31 integrase; a controllable site-specific recombination system of the serine integrase family
Maggie Smith (University of Aberdeen, United Kingdom)
CRISPR interference machines: sentinels for antiviral defence
Malcolm White (St Andrews University, United Kingdom)
ATP-induced helicase slippage reveals highly coordinated subunits
Michelle Wang (Howard Hughes Medical Institute Cornell University, U.S.A.)
Nynke Dekker (Technical University Delft, Netherlands)
Pete McGlynn (University of Aberdeen , United Kingdom)
Ralf Seidel (BIOTEC, TU-Dresden, Germany)
Structural basis of transcription initiation
Richard Ebright (Rutgers, U.S.A.)
Single molecule visualization of protein-DNA complexes: watching machines at work
Steve Kowalczykowski (University of California, Davis, U.S.A.)
To what extent are the central dogma enzymes machines
Taekjip Ha (University of Illinois, U.S.A.)
Bottom-up reconstruction of DNA repair pathways at single-molecule resolution
Terence Strick (Institut Jacques Monod, France)
Vincent Croquette (Ecole Normale Supérieure, France)
Xiaodong Zhang (Imperial College London, United Kingdom)
Organizers: Achillefs Kapanidis (University of Oxford, United Kingdom)
Mark Dillingham (University of Bristol, United Kingdom)
Marshall Stark (University of Glasgow, United Kingdom)
Richard Bowater (University of East Anglia, United Kingdom)

19 Aug - 23 Aug 2012
Oxford
United Kingdom
meeting website