Genomic and Proteomic Approaches to Complex Heart, Lung, Blood, & Sleep Disorders

This highly acclaimed course covers the application of statistics, molecular biology and genetics to the analysis of complex diseases such as asthma, hypertension and coronary heart disease. Both human and animal model data are presented and considered in depth.

Students learn to detect the genetic basis of disease, perform linkage analysis, conduct genome scans, analyze quantitative trait loci, detect gene interactions, map complex disease genes and clone genes. Emphasis is also placed on how to characterize gene function using the latest in biochemical and molecular genetic techniques. Contemporary approaches to gene discovery such as mutagenesis, microarray analysis, comparative genomics and SNP discovery and analysis are also covered. Social and ethical issues surrounding the generation and use of genetic information are discussed during the course.

Intensive hands-on workshops further expose students to the bioinformatics tools such as: Omim, MGD, Unigene, GeneBank, Blast, Gene-scan, SwissProt and Entrez.

The formal lectures, discussion groups, demonstrations and tutorials, study sessions, recreational activities and informal residential interaction provide a unique and varied learning opportunity.

This intensive residential course is designed for 30-40 participants who hold a doctoral degree or equivalent. The course will be held at The Jackson Laboratory’s Highseas Conference Center.
+ show speakers and program
Rev 8-17-11
Genomic and Proteomic Approaches to Complex
Heart, Lung, Blood, & Sleep Disorders
September 8 – 16, 2011
Draft Schedule - subject to change
For more information please contact: laura.ingerson@jax.org
Thursday, September 8
th
Introduction
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
4:00-7:00p.m. Registration and Dinner Buffet
7:00-9:00 Introduction: Starting a Molecular Genetic Study
Greg Hawkins, Ph.D., Wake Forest UniversityRev 8-17-11
Friday, September 9
th
Epidemiology, Linkage
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-8:35 Welcome and Announcements
8:35-8:45 Course Evaluations
Brian Doore, University of Maine
8:45-9:45 Importance of Phenotype in Genetic Studies
Eugene Bleecker, MD, Wake Forest University
9:45-10:00 Break
10:00 -11:00 Life After Linkage: Family Studies
Deborah Meyers, Ph.D., Wake Forest University
11:00-12:00 Introduction to Association Studies
Jianfeng Xu MD, Dr.PH, Wake Forest University
12:00-1:00 Lunch
1:00-1:30 Association Studies ( continues)
Jianfeng Xu MD, Dr.PH, Wake Forest University
1:30 – 2:00 Study Design
Eugene Bleecker, MD, Wake Forest University
Deborah Meyers, Ph.D., Wake Forest University
2:00 – 2:45 Gene-environment Interactions
Terri Beaty Ph.D., Johns Hopkins University
2:45 – 3:00 Break
3:00 – 4:00 Gene-environment Interactions ( continues)
Terri Beaty Ph.D., Johns Hopkins University
5:00–6:00 Wine and Beer Reception: Student and Faculty Introductions
(Highseas Living Room)
6:00–7:00 Dinner
7:00–8:00 Genetic Epidemiology: Questions-Discussion Period
Terri Beaty, Ph.D., Johns Hopkins UniversityRev 8-17-11
Saturday, September 10
th
GWAS
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:30 Current Advances in Genome Sequencing
Greg Hawkins, Ph.D., Wake Forest University
9:30-9:45 Break
9:45-10:45 RNAseq and RNAseq analysis
Matt Hibbs, Ph.D., The Jackson Laboratory
10:45-12:00 Introduction to Genome Wide Association Studies
Deborah Meyers, Ph.D., Wake Forest University
12:00-1:00 Lunch
1:00-2:00 Genome Wide Association Studies: Results and Implications
Jianfeng Xu MD, Dr.PH, Wake Forest University
2:00-2:15 Break
2:15- 3:45 Genome Wide Association Studies-III and Beyond
Nancy Cox, PhD, University of Chicago
3:45-6:00 Free time
6:00-7:00 Dinner
7:00- 8:30 Beyond GWAS – group discussion
Nancy Cox, Jianfeng Xu, Deb MeyersRev 8-17-11
Sunday, September 11
th
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:30 Epigenetics
Greg Hawkins, Ph.D., Wake Forest University
9:30-10:00 Break, Group Photo
10:00-11:15 Genetics of Asthma
Eugene Bleecker, M.D., Wake Forest University
11:15-12:00 After the GWAS, Then What?
Deborah Meyers Ph.D., Wake Forest University
12:00-1:00 Lunch
1:00-2:00 Pharmacogenetics
Eugene Bleecker, M.D., Wake Forest University
2:00-3:00 CD14 as a Model for Gene-Environment Interaction
Donata Vercelli, M.D., University of Arizona
3:00-3:15 Break
3:15-5:00 Medical Genetics via NCBI
Donna Maglott, Ph.D., National Center for Biotechnology Information
5:00-6:00 Free Time
6:00-7:00 Dinner
7:00-9:00 Computer Workshop NCBI
Donna Maglott, Ph.D., National Center for Biotechnology Information
NCBI, Entrez, dbSNPRev 8-17-11
Monday, September 12
th
QTL Studies, Computer Resources
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:45 Why Human Geneticists Need to Know About Mice
Ron Korstanje, Ph.D., The Jackson Laboratory
9:45-10:45 Complex Trait Analysis with Inbred Line Crosses
Gary Churchill, Ph.D., The Jackson Laboratory
10:45-11:00 Break
11:00-12:00 From QTL to Gene
Ron Korstanje, Ph.D., The Jackson Laboratory
12:00-1:00 p.m. Lunch
1:00-2:00 Bioinformatic Toolbox for Narrowing QTLs
Luanne Peters, Ph.D., New York Blood Center
2:00-3:00 Practical Bioinformatics for Candidate Gene Analysis
Judy Blake, Ph.D., The Jackson Laboratory
3:00-3:15 Break
3:15-4:00 The role of rare and functional coding variants in disease risk -
DNA sequencing and association studies
Rasika Mathias, ScD, Johns Hopkins University General Internal
Medicine / Allergy and Clinical Immunology
Computer Workshops Choices:
4:00-6:00 Mouse Genome Informatics
Judy Blake, Ph.D., David Shaw, M.S., The Jackson Laboratory
JQTL
Keith Sheppard, M.S., The Jackson Laboratory
Mouse Phenome Database
Molly Bogue, Ph.D., The Jackson Laboratory
6:00-7:00 Dinner
7:00-8:00 Workshop - The role of rare and functional coding variants in
disease risk - DNA sequencing and association studies
Rasika Mathias, ScD, Johns Hopkins University General Internal
Medicine / Allergy and Clinical ImmunologyRev 8-17-11
Tuesday, September 13
th
QTL, Microarrays, Functional Studies
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:15 Functional Characterization of a Gene: IL13
Donata Vercelli, M.D., University of Arizona
9:15-10:30 Statistical Design and Analysis of Gene Expression Microarray
Experiments
Gary Churchill, Ph.D., The Jackson Laboratory
10:30-10:45 Break
10:45-12:00 Using Microarrays in Complex Trait Analysis
Naftali Kaminski, M.D., University of Pittsburgh Medical Center
12:00-1:00 p.m. Lunch
Faculty Meeting
1:00-2:30 Pathways and Gene Set Enrichment Analysis
Ben King, M.S., Mount Desert Island Biological Laboratory
2:30-2:45 Break
2:45-4:00 In Vitro Analysis of Gene Function
Joachim Herz MD, University of Texas, Southwestern
4:00-6:00 Free Time
6:00-7:00 Dinner
7:00-9:00 Computer Workshops (sequential)
1. Microarrays – Practical Approaches
Naftali Kaminski, M.D., University of Pittsburgh Medical Center
2. Pathways Analysis of Array Datasets
Ben King, M.S, Mount Desert Island Biological LaboratoryRev 8-17-11
Wednesday, September 14
th
Complex traits, Functional Studies
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:30 Animal Models – Transgenics and Knockouts
Joachim Herz MD, University of Texas, Southwestern
9:30-9:45 Break
9:45-10:45 Zebrafish Model
Barry Paw, M.D., Ph.D., Harvard Medical School/Brigham & Women’s
Hospital
10:45-12:00 Cardiovascular
Patrick Ellinor, M.D., Ph.D., Massacheusetts General Hospital
12:00-1:00 Lunch
1:00-2:30 Rat
Howard Jacob, Ph.D, Medical College of Wisconsin
2:30-2:45 Break
2:45-4:00 Genetic Studies of Blood Phenotypes
Luanne Peters, Ph.D, New York Blood Center
4:00 – 6:00 Free Time
6:00-7:00 Dinner
7:00-9:00 Ethics
Deborah Meyers, Ph.D., Wake Forest UniversityRev 8-17-11
Thursday, September 15
th
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-9:45 Clinical Phenotyping of Mice to Detect Cardiovascular and
Metabolic Disorders
Karen Svenson, Ph.D., The Jackson Laboratory
9:45-10:00 Break
10:00-11:00 Role of microRNAs in Complex Lung Diseases
Naftali Kaminski, M.D., University of Pittsburgh Medical Center
11:00-12:00 Sleep Disorders
Allan Pack, M.B., Ch.B, Ph.D., Univ. of Pennsylvania
12:00-1:00 p.m. Lunch
1-00-2:30 Proteomics-Review of Methodologies and Technologies
Andy Greene, Medical College of Wisconsin
2:30-
Free Time
Dinner on your own
Work on Student ProposalsRev 8-17-11
Friday, September 16
th
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
7:30-8:30 a.m. Breakfast
8:30-10:30 Proteomic Approaches to Understanding Complex Phenotypes
Andy Greene, Ph.D., Medical College of Wisconsin
10:30-10:45 Break
10:45-12:00 Haplotype Association Mapping with EMMA Correction Server: A
Practical Guide
Jill Recla, The Jackson Laboratory
12:00-1:00 Lunch
1:00-2:30 Web-based Systems Genetic Analysis
Elissa Chesler, Ph.D., The Jackson Laboratory
2:30-6:00 Free Time
Work on Student Proposals
6:00-7:00 Lobster Dinner
7:00- Student Grant Proposal Presentations
Deborah Meyers, Ph.D., Wake Forest University
Eugene Bleecker, MD, Wake Forest UniversityRev 8-17-11
Saturday, September 17
All lectures and workshops are on the 3
rd
floor at Highseas unless otherwise noted
8:00-9:00 a.m. Breakfast
Depart all Bedrooms by 9:00am for cleaning staff
Students can be on 1
st
floor till time to depart

27 Sep - 6 Oct 2012

Bar Harbor
United States of America
meeting website