21st Annual Short Course on Experimental Models of Human Cancer

The Jackson Laboratory presents this graduate-level genetics course for predoctoral and postdoctoral students as well as established investigators entering the field of mouse genetics. The course focuses on the mouse as an experimental tool in cancer research.

Workshops will include: mouse genome informatics, laboratory animal biomethods (optional), gross pathology, necropsy and tumor histo-pathology. The intensive course offers a mix of formal lectures, discussion groups, demonstrations, workshops and tutorials. The course is held in a retreat-like setting and is limited to 35 participants to ensure a supportive learning atmosphere with exceptional interaction between students and faculty.

Topics include(preliminary list):

Genetics of the laboratory mouse
Tools for genetic analysis
Developmental genetics and cancer
Genetic models in cancer research
Genetics of inbred mouse strains
Spontaneous/induced mutants
Lab animal husbandry
Genetic mapping, physical mapping
Candidate gene identification
Statistical genetics
Complex trait analysis
Gene expression analysis
Strategies in induced mutagenesis
Bio-informatics in genetics and genomics
Development, growth control and malignancy
Mouse models for cancer research
+ show speakers and program
REVISED 8/21/11
20
th
ANNUAL SHORT COURSE ON EXPERIMENTAL MODELS OF HUMAN CANCER
August 19 – 27 , 2011
For more information please contact Nancy Place, nancy.place@jax.org
REVISED Schedule - subject to change
Friday, August 19
12:30 PM Arrival at Highseas anytime after 12:30 PM
4:00 Reception - Highseas Lobby
Location – Highseas Conference Room – 3
rd
Floor
5:00 Course Evaluations
Brian Doore, M.S., University of Maine, Center for Research and Evaluation
5:15 History of The Jackson Laboratory in Cancer Research
Barbara Knowles, Ph.D., IMCB/A*STAR, Singapore
6:00 Dinner – Highseas Dining Room
Free Evening
Saturday, August 20 (Highseas and GRB Training Lab)
7:00 – 8:00am Breakfast – Highseas
BACKGROUND SESSIONS
8:20 AM Pathology and histopathology of normal and neoplastic tissue: an
overview Oded Foreman, D.V.M., ACVP, The Jackson Laboratory
9:30 Group A - Colony management workshop (Highseas)
• Mouse Genetics and Strain Nomenclature: What’s in a Name?
Jennifer Corrigan, M.S., The Jackson LaboratoryREVISED 8/21/11
• Practical aspects of using mice in biomedical research:
breeding strategies
Dorcas Corrow, B.S., L.A.T.G., The Jackson Laboratory (retired)
• Break
• Practical aspects of using mice in biomedical research: Issues
in Animal Health
Peggy Danneman, VMD, MS, DACLAM, The Jackson Laboratory
9:30 Group B Van Transportation to GRB Training Lab
• Pathology and necropsy workshop (Group B) (GRB Training
Lab)
Oded Foreman, D.V.M., ACVP, The Jackson Laboratory
12:15 PM Group B Van Transportation to Highseas
12:30 PM Lunch Highseas Dining Room
1:30 Group B - Colony management workshop (Group B) (Highseas)
• Mouse Genetics and Strain Nomenclature: What’s in a Name?
Jennifer Corrigan, M.S., The Jackson Laboratory
• Practical aspects of using mice in biomedical research:
breeding strategies
Dorcas Corrow, B.S., L.A.T.G., The Jackson Laboratory (retired)
• Break
• Practical aspects of using mice in biomedical research: Issues
in Animal Health
Peggy Danneman, VMD, MS, DACLAM, The Jackson Laboratory
1:30 – Group A Van Transportation to GRB Training Lab
• Pathology and necropsy workshop (Group A) (GRB Training
Lab)
Oded Foreman, D.V.M., ACVP, The Jackson Laboratory
4:30 Group A Van Transportation to Highseas
6:00 Lobster Dinner with Faculty Highseas Dining RoomREVISED 8/21/11
Sunday, August 21
7:00 – 8:00am Breakfast - Highseas
Location – Highseas Conference Center
FUNDAMENTALS
8:30 AM Mouse Genetics
Nancy Jenkins, Ph.D., IMCB/A*STAR, Singapore
9:30 Experimental design
Michael Festing, Ph.D., University of Leicester
10:30 Break
11:00 The Knockout Mouse Project
Mark Moore, Ph.D, National Institutes of Health
12:00 PM Lunch – Highseas Dining Room
1:30 Humanized SCID Mouse Models for Cancer Research
Lenny Shultz, Ph.D, The Jackson Laboratory
2:30 Harnessing transposons for cancer gene discovery
Neal G. Copeland, Ph.D., IMCB/A*STAR, Singapore
3:30 Break
4:00 Integrated approaches to deciphering biological function
Olga Troyanskaya, Ph.D., Princeton University
6:00 Dinner – Highseas Dining Room
7:00 Discussion with day’s Faculty
Highseas Sun Porch
Monday, August 22
7:00 – 8:00am Breakfast – Highseas
8:15 AM Van Transportation to Main Lab
Location – CC Little Auditorium
STEM CELLSREVISED 8/21/11
8:30 Causes and Consequences of microRNA Dysregulation in Cancer
Carlo M. Croce, M.D., The Ohio State University Comprehensive Cancer Center
9:30 Cloning, imprinting and reprogramming: path to the stem cells
Davor Solter, M.D., Ph.D., IMCB/A*STAR, Singapore
10:30 Break
11:00 Pluripotency, stem cells and epigenetic reprogramming
Rudolph Jaenisch, M.D., Whitehead Institute
12:00 PM Lunch - Roscoe’s
1:30 Some Cancers Follow A Stem Cell Model and Some Don't
Sean Morrison, Ph.D., University of Michigan
2:30 Break
3:00 Lgr5 Stem Cells in Epithelial Self-Renewal and Cancer
Nick Barker, Ph.D., IMCB/A*STAR, Singapore
4:00 ES Cell/iPS Workshop
Steve Murray, Ph.D., The Jackson Laboratory
Michael Wiles, Ph.D., The Jackson Laboratory
5:00 Van Transportation to Highseas
6:00 Dinner – Highseas Dining Room
7:00 Discussion with day’s Faculty
Highseas Sun Porch
Tuesday, August 23
7:00 – 8:00am Breakfast - Highseas
8:15 AM Van Transportation from Highseas to Main Lab
Location – CC Little Auditorium
PATHWAYS TO CANCER
8:30 Viruses and cancer
Susan Ross, Ph.D., University Pennsylvania
9:30 Systems Genetics of Metastasis Susceptibility
Kent Hunter, Ph.D., NCIREVISED 8/21/11
10:30 Break
11:00 Modeling the Ras Pathway in Cancer
Karen Cichowski, Ph.D., Harvard University
12:00 PM Lunch - Roscoe’s
1:30 Insights into Mechanisms of Leukemia Development and Drug
Responses Using Oncogene Knockin Mice
Theodora Ross, M.D., Ph.D., University of Michigan Comprehensive Cancer
Center
2:30 Lecture Title TBA
James Allison, Ph.D., Memorial Sloan-Kettering Cancer Center
3:30 Optional – Perfusion Demonstration – Necropsy Lab
3:30 Van Transportation to Highseas for those not viewing demonstration
FREE TIME - HIKE
4:15 Van Transportation to Highseas for those viewing demonstration
6:00 Dinner – Highseas Dining Room
7:00 Discussion with day’s Faculty
Highseas Sun Porch
Wednesday, August 24
7:00 – 8:00am Breakfast - Highseas
8:15 AM Van Transportation from Highseas to Main Lab
SEQUENCING AND GENOMICS
Location – CC Little Auditorium
8:30 EGFR Pathways and Cancer
Pasi Antero Janne, M.D., Ph.D., Harvard University
9:30 Expression profiling in the cancer genome atlas
David Neil Hayes, M.D., M.P.H., University of North Carolina, Lineberger
Comprehensive Cancer Center
10:30 BreakREVISED 8/21/11
11:00 Cancer gene discovery in the mouse
David Adams, Ph.D., Wellcome Trust Sanger Institute
12:00 PM Lunch – Roscoe’s
1:30 HANDS-ON WORKSHOP
(Auditorium)
Carol Bult, Ph.D., The Jackson Laboratory
Joel Graber, Ph.D., The Jackson Laboratory
Matt Hibbs, Ph.D., The Jackson Laboratory
4:30 Van Transportation to Highseas
6:00 Dinner – Highseas Dining Room
7:00 Discussion with day’s Faculty
Highseas Sun Porch
Thursday, August 25
7:00 – 8:00am Breakfast - Highseas
Location – Highseas Conference Room – 3
rd
Floor
CANCER PROGRESSION
8:30 Mechanisms of malignant progression
Robert Weinberg, Ph.D., Whitehead Institute
10:30 Break
11:00 Lung Cancer Progression
Tyler Jacks, Ph.D., Massachusetts Institute of Technology
12:00 PM Lunch – Highseas Dining Room
Discussion with the day’s faculty during lunch
2:00 Proteomic approaches to identifying new cancer markers
Samir Hanash, M.D., Ph.D., Fred Hutchison Cancer Research Center
3:00 Sequencing the cancer genome
Elaine Mardis, Ph.D., Washington University
4:00 Break
4:30 Personalized medicine
Raju S. Kucherlapati, Ph.D., Harvard Medical SchoolREVISED 8/21/11
6:00 Lobster Dinner Highseas Dining Room
Friday, August 26
7:00 – 8:00am Breakfast – Highseas
8:15 AM Van Transportation to Main Lab
Location – CC Little Auditorium
TRANSLATION
8:30 Identifying Molecular Targets for the Treatment of Human Brain Cancer
Eric Holland, M.D., Ph.D., Memorial Sloan Kettering Cancer Center
9:30 Why don’t we get more cancer?
Mina Bissell, Ph.D., Lawrence Berkeley National Laboratory
10:30 Break
11:00 Tumor Angiogenesis And Microenvironment
Rakesh K. Jain, Ph.D., Harvard Medical School
12:00 PM Lunch - Roscoe’s
1:30 Cancer treatment strategies
David Tuveson, M.D. Ph.D., Cancer Research UK Cambridge Research
Institute
2:30 Polymorphisms in Maternal Effect Genes are Associated with Infertility,
Autism and early onset Cancers in the Offspring : new methods for
uncovering the genetic origins of diseases
Arnold Levine, Ph.D., Institute for Advanced Study
3:30 Break
4:00 Zebrafish Models to Dissect Human Cancer Pathways
Thomas Look, M.D., Dana Farber Cancer Institute
5:00 Van Transportation to Highseas
6:00 Dinner – Highseas Dining Room
7:00 Discussion with day’s Faculty
Highseas Sun PorchREVISED 8/21/11
Saturday, August 27
7:00 – 8:00am Breakfast - Highseas
Location – Highseas Conference Center
MODELING CANCER
8:30 The heat-shock response and tumorigenesis: stress phenotype of
cancer
Chengkai Dai, Ph.D., The Jackson Laboratory
9:30 Modeling Chromosome Instability in Cancer
Kevin Mills, Ph.D., The Jackson Laboratory
10:30 Break
11:00 Discussion with Day’s Faculty
12:00 PM Lunch – Highseas Dining Room
FREE AFTERNOON
6:00 Dinner – Highseas Dining Room
Sunday, August 28
7:00 – 8:30am Breakfast - Highseas
Departures

24 Aug - 1 Sep 2012

Bar Harbor
United States of America
meeting website