PROTEIN FOLDING IN THE CELL


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Sunday, July 29, 2012
4:00PM – 9:00AM Conference Registration
6:00PM – 7:00 PM FASEB Opening Reception
7:00PM – 8:30 PM Dinner
8:45PM – 10:00PM Ulrich Hartl, Max Planck Institute, Martinsreid, German
Chaperone-mediated folding in health and disease
Monday, July 30, 2012
7:30AM – 9:00AM Breakfast
Session 1: 9:00AM – 12:15PM Principles of Protein Folding
Jane Clarke, Univ. of Cambridge, U.K.
9:00AM – 9:15AM Welcome from FASEB
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
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9:15AM - 9:45AM Jane Clarke, Univ. of Cambridge, U.K.
Biophysical and structural studies of protein folding
9:45AM –10:15AM Lynne Regan, Yale University
Hsp90 dependent folding and its regulation
10:15AM – 10:30 AM Short Talk Selected From Submitted Abstracts
10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM Adrian Elcock, Univ. of Iowa
Molecular simulations of protein folding in vivo
11:30AM – 12:00PM Elizabeth Craig, Univ. of Wisconsin, Madison
The diversity of Hsp70:J-protein function
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 1 – even numbers
6:00PM – 7:00PM Dinner
Session 2: 7:00PM – 9:45PM Function of Chaperone Machines
Elke Deuerling, Konstanz Univ., Germany
7:00PM - 7:30PM Jonannes Buchner, Technische Universitaet, Munich, Germany
Mechanistic aspects of molecular chaperones
7:30PM – 8:00PM Lila Gerasch University of Massachusetts, Amherst
The allosteric landscape of Hsp70 molecular chaperones
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Kazuhiro Nagata, Kyoto Sangyo Univ, Japan
Protein folding and quality control in the ER
9:15PM – 9:45PM Elke Deuerling, Konstanz Univ., Germany
Ribosome-associated chaperones as key modulators of protein
homeostasis
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
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Tuesday, July 30, 2012
7:30AM – 9:00AM Breakfast
Session 3: 9:00AM – 12:15PM Protein Folding Networks
Ineke Braakman, Utrecht Univ., Netherlands
9:00AM - 9:30AM Linda Hendershot, St. Jude's Children's Research Hospital
ER DnaJs in folding versus degradation
9:30PM –10:00AM Jonathan Weissman, Univ. of California, San Francisco
New ways to probe the folding network
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM David Agard, Univ. of California, San Francisco
Client Interactions and kinetic control in Hsp90 molecular
chaperones
11:15PM – 11:45PM Ineke Braakman, Utrecht Univ., Netherlands
Glycoprotein folding in the ER
11:45 PM – 12:00 PM Short Talk Selected From Submitted Abstracts
12:00 PM – 12:15 PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM
1:15PM – 2:15PM
Lunch
Round Table Discussion with Speakers
Free Afternoon
4:00PM – 6:00PM Poster Session 2 – odd numbers
6:00PM – 7:00PM Dinner
Session 4: 7:00PM – 9:45PM Cotranslational nascent chain interactions and folding
William Skach, Oregon Health and Science University
7:00PM - 7:30PM John Christodolou, University College of London , UK
Use of NMR to understand the dynamics and folding of nascent
chains
7:30PM – 8:00PM Arthur Johnson, Texas A&M Univ.
Folding during co-translational membrane protein biogenesis
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
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8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Roland Beckman, Univ. of Munich, Germany
CryoEM studies of cotranslational folding and chaperone
interactions
9:15PM – 9:45PM William Skach, Oregon Health and Science University
Ligand Driven Vectorial folding of ribosome-bound CFTR
Wednesday, July 31, 2012
7:30AM – 9:00AM Breakfast
Session 5: 9:00AM – 12:15PM Biology and Biophysics of Amyloids
Chris Dobson, University of Cambridge, UK
9:00AM - 9:30AM Jeffery Kelly, Scripps Institute, La Jolla
The enhanced aromatic sequon dramatically stabilizes
glycoproteins and enhances cellular glycosylation efficiently
9:30PM –10:00AM Helen Saibil, Univ. of London, UK
Yeast prion assemblies
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Sheena Radford, Univ. of Leeds, UK
New approaches and insights into protein folding and misfolding
mechanisms
11:15PM – 11:45 PM Chris Dobson, University of Cambridge, UK
Protein Folding: from in silico to in vivo
11:45 PM – 12:00 PM Short Talk Selected From Submitted Abstracts
12:00 PM – 12:15 PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM
1:15PM – 2:15PM
Lunch
Round Table Discussion with Speakers
Free Afternoon
4:00PM – 6:00PM Poster Session 3 – even numbers
6:00PM – 7:00PM Dinner
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
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Session 6: 7:00PM – 9:45PM Evolution of Proteins and Protein Machines
Susan Lindquist, MIT
7:00PM - 7:30PM Dani Tawfik, Weizmann Inst. of Science, Israel
Protein folding, stability and evolvability
7:30PM – 8:00PM Patricia Clark, Univ. of Notre Dame
Reshaping protein folding funnels by altering translation rate
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM James Bardwell, Univ. of Michigan
Optimization of in vivo folding
9:15PM – 9:45PM Susan Lindquist, Whitehead Institute/MIT
Role of stress in shaping evolution
Thursday, August 2, 2012
7:30AM – 9:00AM Breakfast
Session 7: 9:00AM – 12:15PM Quality Control and Degradation
Randy Hampton, Univ. of California, San Diego
9:00AM - 9:30AM Bernd Bukau, Heidelberg Univ, ZMBH, Germany
Chaperone machines involved in protein disaggregation
9:30PM –10:00AM Erik Lee Snapp, Albert Einstein College of Medicine
Organization of the naive and stress-adapted endoplasmic
reticulum folding environments
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Randy Hampton, Univ. of California, San Diego
Quality control in the cytosol
11:15PM – 11:45 PM Tom Rapoport, Harvard Medical School
Mechanisms of retrotranslocation during ERAD
11:45 PM – 12:00 PM Short Talk Selected From Submitted Abstracts
12:00 PM – 12:15 PM Short Talk Selected From Submitted Abstracts
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
Page 6 of 8
12:15PM – 12:45PM Business Meeting
12:45PM – 1:45PM Lunch
Free Afternoon
1:00PM – 6:00PM Optional Organized Group Activity
4:00PM – 6:00PM Poster Session 4 – odd numbers
6:00PM – 7:00PM Dinner
Session 8: 7:00PM – 9:45PM Stress Responses and Signaling
Lea Sistonen, Turku Centre for Biotechnology, Finland
7:00PM - 7:30PM Carol Gross, Univ. of California, San Francisco
The envelope stress response
7:30PM – 8:00PM Peter Walter, Univ. of California, San Francisco
Unfolded protein response in health and disease
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break
8:30PM – 9:00 PM David Ron, Cambridge University, UK
Transcriptional and post-transcriptional regulation of ER chaperone
activity
9:00PM – 9:30 PM Kazutoshi Mori, Kyoto Univ., Japan
The unfolded protein response in Oryzias latipes
9:30PM – 10:00PM Lea Sistonen, Turku Centre for Biotechnology, Finland
Regulation of the mammalian stress response
Friday, August 3, 2012
7:30AM – 8:30AM Breakfast
Session 9: 8:30AM – 11:30PM Protein Misfolding and Disease
David Ron, Cambridge University, UK
8:30AM - 9:00AM Dan Finley, Harvard Medical School
Regulation of the proteosome by deubiquitinating enzymes
9:00AM – 9:30AM Andy Dillin, Salk Institute
Coordinating proteostasis in a multicellular organism
This activity is not being planned in accordance with the ACCME Standards for Commercial Support.
AMA PRA Category 1 Credit(s)™ will not be offered.
Page 7 of 8
9:30AM – 9:45AM Short Talk Selected From Submitted Abstracts
9:45AM – 10:00AM Break
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM Jeff Brodsky, Univ. of Pittsburgh
Using yeast to explore the molecular basis of human misfolding
disease
10:45AM – 11:15PM Rick Morimoto, Northwestern Univ.
Control of chaperone networks and stress responses by neuronal
signaling
11:15AM – 11:30AM Closing Comments
11:30AM Departures
Boxed Lunches Available

29 Jul - 3 Aug 2012

Saxtons River
United States of America
meeting website