Genome Engineering – Research & Applications


+ show speakers and program
8:45 PM – 10:00 PM Maria Jasin*, Memorial Sloan-Kettering Cancer Center
Genome modification and DNA repair.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
Monday,
September 3, 2012
7:30 AM – 9:00 AM Breakfast
Session 1:
9:00 AM – 12:15 PM
DNA repair – the foundation of genome engineering
Session Chair: Toni Cathomen*, Hannover Medical School
9:00 AM – 9:15 AM Welcome from FASEB
9:15 AM – 9:45 AM Matthew Weitzman, The Children’s Hospital of Philadelphia
Cellular DNA repair response to virus infection
9:45 AM –10:15 AM Travis Stracker*, Institute for Research in Biomedicine, Barcelona
Genetic approaches to understanding the DNA damage response.
10:15 AM – 10:30 AM Short Talk Selected From Submitted Abstracts
10:30 AM – 11:00 AM Group photo & FASEB Sponsored Coffee Break
11:00 AM – 11:30 AM Nancy Maizels*, University of Washington, Seattle
Using pathways optimized by evolution to engineer the genome.
11:30 AM – 12:00 PM TBA
TBA
12:00 PM – 12:15 PM Short Talk Selected From Submitted Abstracts
12:15 PM – 1:15 PM Lunch
Free Afternoon
5:00 PM – 7:00 PM Poster Session 1
7:30 PM – 8:30 PM Dinner
Session 2:
8:30 PM – 10:30 PM
Engineering customized nucleases (I)
Session Chair: Frédéric Pâques*, Cellectis S.A.
8:30 PM – 9:00 PM Julianne Smith*, Cellectis S.A.
Designing meganucleases for human gene therapy.
9:00 PM – 9:30 PM Thomas Lahaye*, Ludwig-Maximilians University, Munich
TAL effectors as a platform to engineer DNA binding domains.
9:30 PM – 9:45 PM Short Talk Selected From Submitted Abstracts
9:45 PM – 10:00 PM Short Talk Selected From Submitted Abstracts
10:00 PM – 10:30 PM Adam Bogdanove, Iowa State University
TAL effector based genome engineering and gene modulation.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
Tuesday,
September 4, 2012
7:30 AM – 9:00 AM Breakfast
Session 3
9:00 AM – 12:15 PM
Engineering customized nucleases (II)
Session Chair: Daniel Voytas*, University of Minnesota
9:00 AM - 9:30 AM Srinivasan Chandrasegaran*, Johns Hopkins University
Zinc finger nucleases – a historic perspective.
9:30 PM –10:00 AM Edward Rebar*, Sangamo BioSciences
Development of targeted nucleases for genome engineering.
10:00 AM – 10:15 AM Short Talk Selected From Submitted Abstracts
10:15 AM – 10:45 AM FASEB Sponsored Coffee Break
10:45 AM – 11:00 AM Short Talk Selected From Submitted Abstracts
11:00 AM – 11:30 AM Alfred Pingoud*, University of Giessen
Fusions of site-specific endonucleases and DNA-binding modules
for targeted DNA cleavage.
11:30 AM – 12:00 PM Scot Wolfe*, University of Massachusetts Medical School
Expanding the flexibility of zinc finger nucleases for targeted
genome editing.
12:15 PM – 1:15 PM Lunch
Free Afternoon
Optional Trip to Barga
7:30 PM – 8:30 PM Dinner
Session 4:
8:30 PM – 10:30 PM
Genome engineering for synthetic biology
Session Chair: Pernette Verschure*, University of Amsterdam
8:30 PM – 9:00 PM Pernette Verschure*, University of Amsterdam
Epigenetic gene regulation of the eukaryotic genome.
9:00 PM – 9:30 PM Martin Fussenegger*, Swiss Federal Institute of Technology
Synthetic gene switches and networks for therapeutic applications.
9:30 PM – 9:45 PM Short Talk Selected From Submitted Abstracts
9:45 PM – 10:00 PM Short Talk Selected From Submitted Abstracts
10:00 PM – 10:30 PM George Church, Harvard Medical School
How to create life.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
Wednesday,
September 5, 2012
7:30 AM – 9:00 AM Breakfast
Session 5
9:00 AM – 12:15 PM
Transposable elements for genome modification
Session Chair: Nancy Craig, Johns Hopkins University
9:00 AM – 9:30 AM Zoltan Ivics*, Max-Delbrück-Center for Molecular Medicine, Berlin
Retargeting Sleeping Beauty transposon insertion.
9:30 PM – 10:00 AM Matthew Wilson*, Baylor College of Medicine
Manipulating transposon integration site selection.
10:00 AM – 10:15 AM Short Talk Selected From Submitted Abstracts
10:15 AM – 10:45 AM FASEB Sponsored Coffee Break
10:45 AM – 11:00 AM Short Talk Selected From Submitted Abstracts
11:00 AM – 11:30 AM Eric Ostertag*, Transposagen
PiggyBac for the creation of rat models.
11:30 PM – 12:00 PM Nancy Craig, Johns Hopkins University
Site-specific insertion of Tn7 transposons.
12:15 PM – 1:15 PM Lunch
Free Afternoon
5:00 PM – 7:00 PM Poster Session 2
7:30 PM – 8:30 PM Dinner
Session 6:
8:30 PM – 10:30 PM
Targeted genome modification with recombinases and
integrases
Session Chair: Anja Ehrhardt*, Ludwig-Maximilians University
8:30 PM – 9:00 PM Anja Ehrhardt*, Ludwig-Maximilians University, Munich
Viral hybrid vectors for in vivo genome engineering.
9:00 PM – 9:30 PM TBA
TBA.
9:30 PM – 9:45 PM Short Talk Selected From Submitted Abstracts
9:45 PM – 10:00 PM Short Talk Selected From Submitted Abstracts
10:00 PM – 10:30 PM Carlos Barbas, The Scripps Research Institute, La Jolla
Structure-guided reprogramming of serine recombinase DNA
sequence specificity.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
Thursday,
Month, Day, 2012
7:30 AM – 9:00 AM Breakfast
Session 7
9:00 AM – 12:15 PM
Genome engineering in model organisms
Session Chair: Dana Carroll*, University of Utah
9:00 AM – 9:30 AM Daniel Voytas*, University of Minnesota
Targeted modifications in plants.
9:30 AM – 10:00 AM Joanna Yeh*, Harvard Medical School
High-throughput targeted mutagenesis in zebrafish.
10:00 AM – 10:15 AM Short Talk Selected From Submitted Abstracts
10:15 AM – 10:45 AM FASEB Sponsored Coffee Break
10:45 AM – 11:00 AM Short Talk Selected From Submitted Abstracts
11:00 AM – 11:30 AM Toni Cathomen*, Hannover Medical School
Targeted gene correction in mouse disease models.
11:30 AM – 12:00 PM Dana Carroll*, University of Utah
Gene targeting in Drosophila with ZFNs and TALENs.
12:15 PM – 12:45 PM Business Meeting
12:45 PM – 1:45 PM Lunch
Free Afternoon
Optional Trip to Lucca
7:30 PM – 8:30 PM Dinner
Session 8:
8:30 PM – 10:30 PM
Genome engineering in stem cells
Session Chair: J. Keith Joung*, Massachusetts General Hospital
8:30 PM – 9:00 PM J. Keith Joung*, Massachusetts General Hospital
Genome engineering in human iPS cells using open-source
designer nucleases.
9:00 PM – 9:30 PM Paula Cannon*, University of Southern California
Genetic modification of human hematopoietic stem cells using zincfinger
nucleases.
9:30 PM – 9:45 PM Short Talk Selected From Submitted Abstracts
9:45 PM – 10:00 PM Short Talk Selected From Submitted Abstracts
10:00 PM – 10:30 PM David Russell*, University of Washington
AAV-mediated genome editing in pluripotent stem cells.
This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA PRA
Category 1 Credit(s)™ will not be offered.
Friday,
September 7, 2012
7:30 AM – 8:30 AM Breakfast
Session 9
8:30 AM – 11:30 PM
Genome engineering for therapeutic applications
Thierry Vandendriessche*, Free University of Brussels
8:30 AM – 9:00 AM Thierry Vandendriessche*, Free University of Brussels
Transposons as a versatile tool for human gene therapy.
9:00 AM – 9:30 AM Luigi Naldini*, San Raffaele Telethon Institute for Gene Therapy
Sustainable gene transfer using zinc-finger nucleases.
9:30 AM – 9:45 AM Short Talk Selected From Submitted Abstracts
9:45 AM – 10:00 AM Break
10:00 AM – 10:15 AM Short Talk Selected From Submitted Abstracts
10:15 AM – 10:45 AM Andrew Scharenberg*, University of Washington, Seattle
Meganuclease-mediated genome engineering of lymphocytes and
stem cells.
10:45 AM – 11:15 AM Philip Gregory*, Sangamo BioSciences
Blocking HIV infection with ZFNs – an update from the clinic.
11:15 AM – 11:30 AM Closing Comments
11:30 AM Departures
Boxed Lunches Available

2 Sep - 7 Sep 2012

Lucca
Italy
meeting website