Tyrosine Kinase Signaling in Cancer, Disease, & Development

Tyrosine Kinase Signaling in Cancer, Disease, & Development
+ show speakers and program
Co-Organizers:
Cindy K. Miranti
Van Andel Research Institute
Grand Rapids, MI
Robert Rottapel
Ontario Cancer Institute
Toronto, ON
Sunday,
July, 22, 2012
4:00PM – 9:00AM Conference Registration

6:00PM – 7:00 PM FASEB Opening Reception

7:00PM – 8:30 PM Dinner

8:45PM – 10:00PM Marsha Rosner
Ben May Cancer Center, University of Chicago
“Identifying Novel Signaling Cascades in Cancer”
Monday,
July, 23, 2012
7:30AM – 9:00AM Breakfast
Session 1:
9:00AM – 12:15PM
Receptor Tyrosine Kinase Signaling I
Session Chair: Morag Park, McGill University

9:00AM – 9:15AM Welcome from FASEB
Organizer: Cindy Miranti

9:15AM - 9:45AM Joseph Schlessinger
Yale University “Cell Signaling by Receptor Tyrosine Kinases: From Basic
Principles to Cancer Therapy”
9:45AM –10:15AM Anne-Claude Gingras
Samuel Lunenfeld Research Institute
“Protein Interactomes”

10:15AM – 10:30 AM Short Talk Selected From Submitted Abstracts
10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM John Kuriyan
University of California Berkley
“Allosteric Mechanisms in the Control of Tyrosine Kinase
Conformations”
11:30AM – 12:00PM Tony Pawson
University of Toronto
“The Phosphotyrosine Signaling Network”
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts

12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Poster Session 1
6:00PM – 7:00PM Dinner
Session 2:
7:00PM – 9:45PM
Receptor Tyrosine Kinase Signaling II
Session Chair: John Kuriyan, UC Berkley

7:00PM - 7:30PM David Stern
Yale University
“Erb Signaling”
7:30PM – 8:00PM Elena Pasquale
Burnham Institute
“Eph Receptor Signaling in Cancer”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Forest White
MIT
“Defining Signaling Pathways by Mass Spec”
9:15PM – 9:45PM Ben Neel
Ontario Cancer Institute
“EGFR and GRB2” Tuesday,
July, 24, 2012
7:30AM – 9:00AM Breakfast

Session 3
9:00AM – 12:15PM
Soluble Tyrosine Kinase Signaling
Session Chair: Elena Pasquale, Burnham Institute

9:00AM - 9:30AM Anne Marie Pendergast
Duke University
“Abl Kinases in Development and Cancer”

9:30PM –10:00AM Angel Nebreda
Spanish National Cancer Center
“Signal Integration by p38 MAPKs”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts
10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15PM Margaret Frame
University of Edinburgh
“FAK and Src in Cell-Cell Adhesion”

11:15PM – 12:00PM Mike Yaffe
MIT
“Phospho-Proteomics and Signaling Networks”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 2:15PM Meet the Expert Luncheon
Free Afternoon

4:00PM – 6:00PM Poster Session 2
6:00PM – 7:00PM Dinner
Session 4:
7:00PM – 9:45PM
Signaling Crosstalk/Membrane Dynamics
Session Chair: Jon Cooper, FHCRC
7:00PM - 7:30PM Stephen Robinson
University of East Anglia
“Unraveling the Molecular Basis of Tumor Angiogenesis”

7:30PM – 8:00PM
David Schlaepfer
University of California San Diego
“Endothelial FAK activity in the control of vascular
permeability and tumor metastasis”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Daniel Leahy
Johns Hopkins
“The Ins and Outs of EGF Receptor Asymmetry”

9:15PM – 9:45PM Doug Lauffenburger
MIT
“ErbB System Signaling Crosstalk with Cytoskeleton and
Migration Regulation”
Wednesday,
July, 25, 2012
7:30AM – 9:00AM Breakfast

Session 5
9:00AM – 12:15PM
Negative Feedback
Session Chair: Daniel Leahy, Johns Hopkins

9:00AM - 9:30AM Jon Cooper
Fred Hutchinson Cancer Research Center
“Negative Regulation of Src-dependent Phenotypes by
Ubiquitin-Mediated Proteolysis”

9:30PM –10:00AM Jeff MacKeigan
Van Andel Research Institute
“Identification of Autophagic Phosphatases
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Kermit Carraway III
University of California Davis
“Mechanisms of ErbB Receptor Tyrosine Kinase Quantity
Control”

11:15PM – 12:00PM Morag Park
McGill University
“Met-Trafficking, Signaling and Tumorigenesis”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon
4:00PM – 6:00PM Workshop: Translating Signaling to the Clinic
6:00PM – 7:00PM Dinner
Session 6:
7:00PM – 9:45PM
Tyrosine Kinases in Disease and Development
Session Chair: Yosef Yarden, Weizmann Institute 7:00PM - 7:30PM Steve Watson
University of Birmingham
“The Platelet hemITAM Receptor CLEC-2 and Lymphatic
Development”

7:30PM – 8:00PM Rejji Kuruvilla
Johns Hopkins
“Endocytic Trafficking of Trk Receptors in Neural
Development”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts
8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Greg Lemke
Salk Institute
“Systems Biology of Tyrosine Kinase Signaling in Immune
Regulation”

9:15PM – 9:45PM Robert Rottapel
Ontario Cancer Institute
“Adaptors in Immune Signaling”
Thursday,
July, 26, 2012
7:30AM – 9:00AM Breakfast

Session 7
9:00AM – 12:15PM
Cancer
Session Chair: Greg Lemke, Salk Institute

9:00AM - 9:30AM Senthil Muthuswamy
Ontario Cancer Institute
“Cell Polarity Pathways and ErbB2 Regulated Breast Cancer”
9:30PM –10:00AM Don Botarro
NIH
“HGF/Met Signaling in Cancer”
10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM FASEB Sponsored Coffee Break
10:45AM – 11:15PM Susan Waltz
University of Cincinnati
“The wRONg Path to Prostate Cancer: Ron Receptor Function
during Tumorigenesis”
11:15PM – 12:00PM George Vande Woude
Van Andel Research Institute
“Phenotypic Switching and the Molecular Anatomy of
Malignant Progression (E-M-T/M-E-T)”
12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts
12:15PM – 1:15PM Lunch
Free Afternoon

1:00PM – 5:00PM Optional Organized Group Activity
5:00PM – 6:00PM Business Meeting
6:00PM – 7:00PM Dinner
Session 8:
7:00PM – 9:45PM
Microenvironment/Metastasis
Session Chair: Cindy Miranti, VARI
7:00PM - 7:30PM William Muller
McGill University
“Microenvironment in Breast Cancer”
7:30PM – 8:00PM Sara Courtneidge
Burnham Institute
“The Control of Invasion and Metastasis”
8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break
8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts
8:45PM – 9:15PM Ashani Weeraratna
Wistar Institute
“Hear the Wnt Ror: The Intricacies of Wnt Signaling in
Melanoma Metastasis”

9:15PM – 9:45PM Yosef Yarden
Weizmann Institute
“Roles for EGF-like Growth Factors in Tumor Progression and
Metastasis”
Friday,
July, 27, 2012
7:30AM – 8:30AM Breakfast
Session 9
8:30AM – 11:30PM
Therapeutics
Session Chair: Sara Courtneidge, Burnham Institute

9:00AM - 9:30AM Donald McDonald
University of California San Francisco
“Receptor Tyrosine Kinase Inhibitor Targeting of Tumor
Angiogenesis, Invasion, and Metastasis”

9:30AM – 10:00AM Sam Lee Harvard
“DDR1 RTK as an emerging target in cancer therapeutics”

10:00AM – 10:15AM Break

10:15AM – 10:45AM Susan Eccles
Institute of Cancer Research
“Targeting Downstream Signaling Pathways for Effective
Therapeutic Intervention”
10:45AM – 11:15PM Heidi Greulich
Dana Farber Cancer Institute
“Functional Analysis of Receptor Tyrosine Kinase Mutations in
Lung Cancer”
11:15AM Closing Comments
Organizer - Robert Rottapel
11:30AM Departures
Boxed Lunches Available

22 Jul - 27 Jul 2012
snowmass village
United States of America
meeting website