Biological Methylation: From DNA and Histones to Disease

Biological Methylation: From DNA and Histones to Disease
+ show speakers and program
Co-Organizers:
Brian D. Strahl
University of North Carolina
Chapel Hill, NC
Paul A. Wade
NIEHS
Research Triangle Park, NC
Sunday, August 12, 2012
4:00 PM – 9:00 PM Conference Registration
6:00 PM – 7:00 PM FASEB Opening Reception
7:00 PM – 8:30 PM Dinner
8:45 PM – 10:00 PM Keynote address
Steve Henikoff
Fred Hutchinson Cancer Center
“DNA methylation in gene bodies: what, why and how?” This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA
PRA Category 1 Credit(s)™ will not be offered.
Monday, August 13, 2012
7:30 AM – 9:00 AM Breakfast
Session 1: Methylation in Development/pluripotency
9:00 AM – 12:15 PM Laurie Jackson-Grusby, Harvard
9:00 – 9:15 AM Welcome from FASEB
9:15 – 9:45 AM Laurie Jackson-Grusby (Harvard University)
“Methylation, development and pluripotency”
9:45 – 10:15 AM GertJan Veenstra (Radboud University) “Development of
chromatin states during Xenopus embryogenesis”
10:15 – 10:45 AM Group photo and FASEB sponsored coffee break
10:45 – 11:15 AM Albert Jeltsch (Jacobs University)
“Reading and writing of methylation marks”
11:15 – 11:45 PM TBD
11:45 – 12:15 PM Alex Meissner (Harvard University)
“DNA methylation dynamics in development”
12:15 – 1:15 PM Lunch
4:00 PM – 6:00 PM Poster Session 1
6:00 PM – 7:00 PM Dinner
Session 2: Methyl-binding modules
7:00 PM – 9:45 PM Tatiana Kutateladze, Univ of Colorado
7:00 – 7:30 PM Tatiana Kutateladze (University of Colorado)
“Molecular insight into histone recognition by PHD fingers”
7:30 – 8:00 PM Or Gozani (Stanford University)
“Lysine methylation in chromatin and disease regulation”
8:00 – 8:30 PM Cheryl Arrowsmith (University of Toronto)
“Structural and chemical biology of chromatin modulating factors”
8:30 – 8:45 PM Break
8:45 – 9:15 PM Sepideh Khorasanizadeh (Sanford/Burnham Institute) This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA
PRA Category 1 Credit(s)™ will not be offered.
“Functions of chromodomains in epigenetic regulation”
9:15 – 9:45 PM Wolfgang Fischle (Max Planck Institute)
“Molecular analysis of histone methylation readout”
Tuesday, August 14, 2012
7:30 – 9:00 AM Breakfast
Session 3: Methylation in Disease
9:00 AM – 12:00 PM Paula Vertino, Emory University
9:00 – 9:30 AM Peter Jones (USC)
“Targeting the cancer epigenome for therapy”
9:30 – 10:00 AM Tim Huang (University of Texas Health Sciences Center)
“Methylation profiling of CpG islands and neighboring regions in
cancer”
10:00 – 10:30 AM FASEB sponsored coffee break
10:30 – 11:00 AM Paula Vertino (Emory University)
“Chromatin determinants of aberrant DNA methylation in cancer”
11:00- 11:30 AM Ken Nephew (Indiana University)
“Epigenetic-targeting therapies to overcome chemotherapy
resistance”
11:30 AM – 12:00 PM Ari Melnick (Weil Cornell Medical College)
“Epigenetic mechanisms driving leukemogenesis”
12:15 – 1:15 PM Lunch
1:15 PM – 2:15 PM Meet the Experts session
6:00 PM – 7:00 PM Dinner
Session 4: Protein Methylation
7:00 PM – 9:45 PM Steven Clarke, UCLA
7:00 – 7:30 PM Mark Bedford (MD Anderson)
“Identifying methyl-arginine substrates and effector modules”
7:30 – 7:45 PM short talk selected from abstracts This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA
PRA Category 1 Credit(s)™ will not be offered.
7:45 – 8:15 PM Stephane Richard (Lady Davis Institute)
“The role of arginine methylation in DNA damage signaling”
8:15 – 8:30 PM Break
8:30 – 9:00 PM Said Sif (Ohio State University)
“Role of protein arginine methylation in cancer”
9:00 – 9:15 PM short talk selected from abstracts
9:15 – 9:45 PM Steven Clarke (UCLA)
“The human and yeast methyltransferasomes – what’s in it for
proteins?”
Wednesday, August 15, 2012
7:30 – 9:00 AM Breakfast
Session 5 Enzymes, Mechanisms and Structures
9:00 AM – 12:00 PM Xiaodong Cheng, Emory University
9:00 – 9:30 AM Xiaodong Cheng (Emory University)
“Mechanisms of coordinated DNA methylation and histone
methylation”
9:30 – 9:45 AM Yujun (George) Zheng (Georgia State University)
“Mechanism and inhibition of arginine methylation”
9:45 – 10:15 AM Squire Booker (Penn State University)
“A radical-dependent strategy for methylation of rRNA leading to
antibiotic resistance”
10:15 – 10:45 FASEB sponsored coffee break
10:45 – 11:15 AM Shoji Tajima (Osaka University)
“Multiple-step process of maintenance methylation”
11:15 – 11:30 AM Short talk selected from abstracts
11:30 AM – 12:00 PM Chuan He (University of Chicago)
“Mammalian demethylases that catalyze mRNA demethylation in
biological regulation”
12:15 – 1:15 PM Lunch This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA
PRA Category 1 Credit(s)™ will not be offered.
4:00 – 6:00 PM Poster session 2
6:00 – 7:00 PM Dinner
Session 6 Histone Methylation
7:00 – 9:45 PM Joanna Wysocka, Stanford
7:00 – 7:30 PM Joanna Wysocka (Stanford University)
“Histone methylation in early development”
7:30 – 7:45 PM short talk selected from abstracts
7:45 – 8:15 PM Alex Ruthenburg (University of Chicago)
“Uncle SAM wants you: noncoding RNA recruitment of histone
methylation complexes”
8:15 – 8:30 PM Break
8:30 – 9:00 PM Sharon Dent (MD Anderson)
“Exploring functions for histone methylases”
9:00 – 9:15 PM short talk selected from abstracts
9:15 – 9:45 PM Thomas Jenuwein (Max Planck Institute)
“Histone methyltransferases”
Thursday, August 16, 2012
7:30 – 9:00 AM Breakfast
Session 7 DNA and histone demethylation
9:00 AM – 12:00 PM Rob Klose, Oxford
9:00 – 9:30 AM Rob Klose (Oxford University)
“Histone demethylation at CpG islands”
9:30 – 9:45 AM short talk selected from abstracts
9:45 – 10:15 AM Johnathan Whetstine (Harvard University)
“Bridging cell cycle and organismal behavior through histone
demethylation”
10:15 – 10:45 AM FASEB sponsored coffee break
10:45 – 11:15 AM Wolf Reik (Babraham Institute)
“Epigenetic reprogramming in mammalian development” This activity is not being planned in accordance with the ACCME Standards for Commercial Support. AMA
PRA Category 1 Credit(s)™ will not be offered.
11:15 – 11:30 AM Anjana Rao (La Jolla Institute for Allergy and
Immunology)
“TET proteins and DNA methylation”
11:30 AM – 12:00 PM Guoliang Xu (Shanghai Institute for Biological Sciences)
“DNA oxidation towards totipotency in mammalian development”
12:00 – 12:30 PM Business Meeting
12:30 – 1:30 PM Lunch
Free Afternoon
6:00- 7:00 PM Dinner
Session 8 DNA methylation – genomics and patterning
7:00 – 9:45 PM Steve Jacobsen, UCLA
7:00 – 7:30 PM Joseph Costello (UCSF)
“Genetic and epigenetic evolution during malignant transformation
of primary low grade tumors”
7:30 – 8:00 PM Chuck Vinson (NCI)
“CpG methylation is needed to activate some tissue specific genes”
8:00 – 8:30 PM Eric Selker (University of Oregon)
“Control of DNA methylation in Neurospora”
8:30 – 8:45 PM Break
8:45 – 9:15 PM Joe Ecker (Salk Institute)
“DNA methylation dynamics in genomes”
9:15 – 9:45 PM Steve Jacobsen (UCLA)
“DNA methylation in Arabidopsis thaliana”
Friday, August 17, 2012
7:30 – 9:00 AM Breakfast

12 Aug - 17 Aug 2012
snowmass village
United States of America
meeting website