The reciprocal interactions of signaling pathways and non-coding RNA

A wide variety - if not all - biological functions depend on the coordinated interactions between non-coding RNA and cell signaling networks that integrate a multitude of environmental cues. This EMBO Workshop in Ascona, Switzerland, will connect researchers working on non-coding RNA such as microRNA or long non-coding RNA and cellular signaling pathways relevant in a broad spectrum of biological functions. This workshop will also provide insight into technology and therapeutic approaches to advance our understanding of molecular networks in health and disease.

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Non-coding RNA has emerged as crucial regulator of gene expression and alternative splicing which provides cells with an exquisite capacity to fine-tune their transcriptome and proteome and thus impact cell functions.


This workshop will cover the interactions of non-coding RNA with cell signaling in:
■Development
■Metabolic and cardiovascular disease
■Stress pathways
■Cancer

Further sessions will address:
■Strategies for target prediction and validation
■New concepts for RNA technology in health and disease


One important family of non-coding RNA is represented by microRNAs. Since their first description, microRNAs have been proven to be a rich resource of regulators that impact on virtually all aspects of biology. Direct linkages between the activation of cell signaling pathways and the action of non-coding RNA have now been established. Moreover, there is emerging evidence that these reciprocal interactions between the worlds of cell signaling and non-coding RNA are targets of alterations in human diseases ranging from cancer to metabolic and heart disease. The main goal of this workshop is to bring together scientists from Europe and overseas to share their newest results and insights into topics that directly address the reciprocal interactions of non-coding RNA and cell signaling.

We plan to gather 120 participants to discuss the latest ideas on the mechanisms underlying non-coding RNA and cell signaling interactions. A major purpose of our meeting is to provide a unique forum to enhance the participation of scientists, especially at the junior level, in a stimulating and informal conference together with the top-leading scientists in this field. We specifically encourage young scientists to submit an abstract that could be chosen as a short talk or poster. The program is designed to allow ample time for participants to interact scientifically and socially and will include two poster sessions.

+ show speakers and program


Maha


Abdellatif


New Jersey Medical School


US




Reuven


Agami


The Netherlands Cancer Institute


NL




Robert


Blelloch


University of California San Francisco


US




Thomas


Brabletz


University of Freiburg Medical Center


DE




Jens


Brüning


University of Cologne


DE




Stefanie


Dimmeler


Goethe University Frankfurt


DE




Christine


Esau


Regulus Therapeutics


US




Manel


Esteller


Bellvitge Biomedical Research Institute


ES




Elsa R.


Flores


University of Texas


US




Akiko


Hata


Tufts University School of Medicine


US




Lin


He


University of California at Berkeley


US




Sakari


Kauppinen


Santaris Pharma, Hørsholm


DK




Wilhelm


Krek


ETH Zurich


CH




Jan


Krützfeldt


University Hospital Zurich


CH




Jeanni T.


Lee


Harvard Medical School


US




Gunter


Meister


Universität Regensburg


DE




Joshua T.


Mendell


Johns Hopkins University School of Medicine


US




Eric N.


Olson


University of Texas Southwestern Medical Center


US




Stefano


Piccolo


University of Padua


IT




Markus


Stoffel


ETH Zurich


CH




Jernej


Ule


MRC Laboratory of Molecular Biology, Cambridge


UK




Olivier


Voinnet


ETH Zurich


CH




Claes


Wahlestedt


University of Miami Miller School of Medicine


US




Mihaela


Zavolan


University of Basel


CH


16 Sep - 19 Sep 2012
Ascona
Switzerland
meeting website