Bioorganic Chemistry

The Gordon Research Conference on Bioorganic Chemistry was founded in 1992 to bring together scientists from a range of disciplines to present and discuss cutting-edge research at the interface between chemistry and biology. Both fundamental and applied research relevant to academia and industry are highlighted. To maintain a balance between these areas, the conference is organized by two co-chairs, one from academia and one from industry. The conference emphasizes the presentation of techniques or approaches that are broadly applicable across multiple areas of chemical and biological research. Traditionally, small molecules that probe, modulate, or mimic cellular components or processes as well as studies of biology at the molecular level have been of particular interest. The meeting in 2012 will showcase sessions in the areas of medicinal chemistry, drug discovery, chemical biology, chemical proteomics, biosynthesis, synthetic biology, natural products, nucleic acids, and carbohydrates. As a new feature of the meeting, a discussion-based session will be included to foster conversation and ideas on challenges facing the community. For this 2012 meeting, the discussion will focus on "How to make a small molecule modulator to every biology target".

All conferees are encouraged to present posters. Poster presenters should submit an abstract with their applications on the GRC web site. A number of poster presenters will be invited to give short talks. Given the popularity of this meeting, submission of applications by early 2012 is strongly encouraged.

+ show speakers and program
7:35 pm - 9:30 pm Frontiers in Medicinal Chemistry
Discussion Leader: David Ehmann (AstraZeneca)
7:35 pm - 8:00 pm James Bradner (Dana Farber Cancer Institute)
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Paul Richardson (Abbott)
"Modular Probes: Flexibility for Profiling Assays and Chemoproteomics"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Peter Tonge (Stony Brook University)
"Drug-Target Residence Time: Correlating In Vitro Enzyme Inhibition with In Vivo Antibacterial Activity"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Challenging Drug Targets
Discussion Leader: Brian McNaughton (Colorado State University)
9:00 am - 9:30 am Jared Cumming (Merck-Schering)
"Discovery of structurally novel, centrally-active, beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Chris Straub (Novartis)
10:10 am - 10:20 am Discussion
10:20 am Group Photo / Coffee Break
10:50 am - 11:20 am Adrian Whitty (Boston University)
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am TBA (Poster Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm TBA (Poster Talk)
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA (Poster Talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Chemical Biology and Ecology
Discussion Leader: W. Seth Horne (University of Pittsburgh)
7:30 pm - 8:00 pm Jianmin Gao (Boston College)
"Targeting Membrane Lipids with Designed Peptides"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Phil Cole (Johns Hopkins University)
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Christina Grozinger (Pennsylvania State University)
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Chemical Proteomics
Discussion Leader: Champak Chatterjee (University of Washington)
9:00 am - 9:30 am Minkui Luo (Memorial Sloan-Kettering Cancer Center)
"Chemical Biology Approaches to Profile Substrates of Protein Methyltransferases"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Craig Crews (Yale University)
"Small Molecule Control of Intracellular Protein Levels"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Benjamin Cravatt (The Scripps Research Institute)
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am TBA (Poster Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm TBA (Poster Talk)
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA (Poster Talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Community Forum: How to Make a Small Molecule Modulator to A Biological Target
Discussion Leader: Michelle Arkin (University of California, San Francisco)
7:30 pm - 8:00 pm John Overington (Inpharmatica)
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Michael Foley (Broad Institute)
"Design, Synthesis and Characterization of a CNS-Focused Library of Small Molecules"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Barry Morgan (GlaxoSmithKline)
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Nucleic Acid Chemistry and Biology
Discussion Leader: Ming Hammond (University of California, Berkeley)
9:00 am - 9:30 am Anne Baranger (University of California, Berkeley)
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Tamara Hendrickson (Wayne State University)
"Identifying new bacterial players in the Central Dogma"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Samie Jaffrey (Weill Medical College, Cornell University)
"A general strategy for generating genetically encoded sensors using RNA mimics of GFP"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am TBA (Poster Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm TBA (Poster Talk)
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA (Poster Talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Enabling Methods for the Bioorganic Community
Discussion Leader: Stacie Canan (Celgene)
7:30 pm - 8:00 pm Sirano Dhe-Paganon (University of Toronto)
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Michael MacCoss (University of Washington)
"Probing genetic and pharmacologic perturbations using next generation proteomic technologies"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Heather Carlson (University of Michigan, Ann Arbor)
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Biosynthesis of Natural Products and Sugars
Discussion Leader: Tanya Schneider (Connecticut College)
9:00 am - 9:30 am Kevin Walker (Michigan State University)
"Dissecting the Mechanisms of Isozymic Aminomutases"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Jon Thorson (University of Kentucky)
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
10:50 am - 11:20 am Xi Chen (University of California, Davis)
"Sialosides as biological probes"
11:20 am - 11:30 am Discussion
11:30 am - 11:45 am TBA (Poster Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:05 pm TBA (Poster Talk)
12:05 pm - 12:10 pm Discussion
12:10 pm - 12:25 pm TBA (Poster Talk)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Frontiers in Bioorganic Chemistry
Discussion Leader: Jitesh Soares (ACS Chemistry Biology)
7:30 pm - 8:00 pm Carlos Garcia-Echeverria (Sanofi-Aventis)
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Christopher Schofield (Oxford University)
"Discovering and exploiting Novel Post-translational Modifications"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Thomas Kodadek (The Scripps Research Institute, Scripps Florida)
"The development of a simple and accurate blood test for Alzheimer's Disease"

10 Jun - 15 Jun 2012
Andover
United States of America
meeting website