Cardiac Regulatory Mechanisms

The 2012 Cardiac Regulatory Mechanisms Gordon Research Conference is one of the premier meetings for scientists interested in cellular and molecular mechanisms regulating the normal and diseased heart. In addition to the role of Ca in excitation/contraction coupling and contractility that formed the original basis for this meeting, the 2012 meeting will integrate studies at the nexus of Ca, ion channels, redox and kinase signaling, and mitochondria in regulating cardiac cell function and diseases such as sudden arrhythmias, hypertrophy and heart failure. Emerging data has shown an important role for redox and kinase regulation of ion channels and transporters. Compelling data also show cross-talk between kinase and redox signaling. Mitochondria are involved in ion signaling, redox regulation, metabolism and cell death and play an important role in regulating excitation contraction coupling and cardiac function. The meeting will report on mechanisms by which these pathways function and interact. Topics include novel models for studying cardiovascular disease, new mechanisms and targets for redox signaling, signaling via contractile proteins, the intersection of calcium, signaling and hypertrophy, mitochondrial regulation of Ca signaling and cardiac function, the importance of location in signaling, ion channels and arrhythmias and novels aspects of Ca dynamics. The meeting will cover basic mechanism as well as perspectives on translating these findings into a better understanding of disease mechanisms, diagnosis, prevention and treatment. The goal of the meeting is to bring together scientists who can critically evaluate developments at the forefront of cardiovascular research. This is accomplished by including established as well as early career research scientists from the fields of physiology, pharmacology, molecular biology, biochemistry, biophysics and bioengineering, along with physician/scientists with an appreciation for the therapeutic implications of cardiovascular research. Based on past experience, we can guarantee an atmosphere of intense and lively discussions where all participants contribute and learn.

Preliminary List of Topics:

Novel Methods for Studying Cardiovascular Disease
Signaling Via Contractile Proteins
Ion channels and Arrhythmias
Mitochondrial Regulation of Ca Signaling and Cardiac Function
New Mechanisms and Targets for Redox Signaling
The Intersection of Calcium, Signaling Kinases and Hypertrophy
The Importance of Location in Signaling
Novels Regulation of Ca Dynamics


+ show speakers and program
7:30 pm - 7:35 pm Welcome / Introductory Comments by GRC Site Staff
7:35 pm - 9:30 pm Novel Methods for Studying Cardiovascular Disease
Discussion Leaders: Steve Houser (Temple University, Phila, PA) and TBA (Junior Investigator)
7:35 pm - 8:00 pm Howard Rockman (Duke University, Durham, NC)
"New models for cardiovascular disease"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:35 pm Karl-Ludwig Laugwitz (Universit√§t M√ľnchen, Munich, Germany)
"iPS models for arrhythmias"
8:35 pm - 8:45 pm Discussion
8:45 pm - 9:03 pm Eva Van Rooij (miRagen Therapeutics, Boulder, CO)
"micro RNAs as tools for studying cardiovascular disease"
9:03 pm - 9:10 pm Discussion
9:10 pm - 9:25 pm TBA (Late-breaking talk selected from Abstracts)
9:25 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
8:30 am Group Photo
9:00 am - 12:30 pm Mitochondrial Signaling and Cardiac Function
Discussion Leaders: Bob Balaban (NHLBI/NIH) and TBA (Junior Investigator)
9:00 am - 9:25 am Paul Brookes (Rochester Univ, NY)
"Regulation of the mitochondrial KATP channel"
9:25 am - 9:35 am Discussion
9:35 am - 9:53 am Elena Dedkova (Rush University, Chicago, IL)
"Mitochodrial Ca transients"
9:53 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Godfrey Smith (University ofGlasgow, UK)
"Mitochondrial regulation of Ca dynamics"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Peipei Ping (UCLA, CA)
"Mitochondria phospho-proteome"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Luca Scorrano (University of Geneva, Geneva, Switzerland)
"Mitochondrial dynamics and cardiovascular function"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm Yasemin Sancak (Harvard University, Boston, MA)
"Characterization of the mitochondrial Ca uniporter"
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Ion channel protein defects and arrhythmias
Discussion Leaders: David Eisner (Manchester Univ, UK) and Henry Colcraft (Columbia University, NY)
7:30 pm - 7:55 pm David Yue (Johns Hopkins University, Baltimore, MD)
"Regulation of calcium channels"
7:55 pm - 8:05 pm Discussion
7:55 pm - 8:05 pm Stephane Hatem (INSERM/UPMC, Paris, France)
"K channel regulation and trafficking"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:58 pm Tom Hund (Ohio State Univeristy, Columbus, OH)
"Ankyrin-B Dysfunction and Arrhythmias"
8:58 pm - 9:05 pm Discussion
9:05 pm - 9:23 pm TBA (Selected from abstracts)
9:23 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Intersection of Signaling Kinases and Hypertrophy
Discussion Leaders: Wally Koch (Temple University, Phila, PA) and Edward Lakatta (NIA, NIH, Baltimore)
9:00 am - 9:25 am Joan Heller-Brown (UCSD, San Diego, CA)
"CaM kinase and hypertrophy"
9:25 am - 9:35 am Discussion
9:35 am - 9:53 am Jeffrey Erickson (UC Davis, Davis, CA)
"FRET sensor Camui: insights into mechanisms of CaMKII activation"
9:53 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Beth McNally (University of Chicago, IL)
"Sarcomere mutations in human cardiomyopathy"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Roberta Gottlieb (SDSU, San Diego, CA)
"Role of mitophage in cardiac disease"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Mark Sussman (SDSU, San Diego, CA)
"Kinase singaling and hypertrophy"
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm TBA (Selected from abstracts)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm New Mechanisms and Targets for Redox Signaling
Discussion Leaders: Mark Anderson (University of Iowa, Iowa City, IA) and Bjorn Knollmann (Vanderbilt Univ, TN)
7:30 pm - 7:55 pm Jun Sadoshima (UMDNJ, Newark, NJ)
"Identification of novel targets of thioredoxin1 in the heart by thioredoxin-trap mutant"
7:55 pm - 8:05 pm Discussion
7:55 pm - 8:05 pm Barbara Casadei (Oxford University, Oxford, UK)
"Human studies: Uncoupled NOS and EC coupling"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:58 pm Jenny Van Eyk (Johns Hopkins, Baltimore, MD)
"Proteomic changes in resynchronization therapy"
8:58 pm - 9:05 pm Discussion
9:05 pm - 9:23 pm TBA (Selected from abstracts)
9:23 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Signaling Via Contractile Proteins
Discussion Leaders: Litsa Kranias (University of Cincinnati, OH) and TBA (Junior Investigator)
9:00 am - 9:25 am Jolanda Van der Velden (University Medical Center Amsterdam, Netherlands)
"Phosphorylation and redox regulation of sacromere"
9:25 am - 9:35 am Discussion
9:35 am - 10:00 am Lucie Carrier (University of Hamburg, Germany)
"Proteolytic systems in sarcomeropathy"
10:00 am - 10:10 am Discussion
10:10 am Coffee Break
10:40 am - 11:05 am John Solaro (University of Ilinois at Chicago, IL)
"Phosphorylation and redox regulation of sacromere"
11:05 am - 11:15 am Discussion
11:15 am - 11:40 am Mathias Gautel (King's College London, London, UK)
"Cytoskeletal protein kinases"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Jeff Robbins (Cincinnati Children's Hosp, OH)
"Myosin-binding protein C and signaling"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:00 pm - 7:30 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
7:30 pm - 9:30 pm Novels Regulation of Ca2+ Dynamics
Discussion Leaders: Don Bers (UC Davis, Davis, CA) and TBA (Junior Investigator)
7:30 pm - 7:55 pm Jon Lederer (University of Maryland, Baltimore, MD)
"X-ROS signaling in heart: discoveries and insight from a new signaling pathway"
7:55 pm - 8:05 pm Discussion
7:55 pm - 8:05 pm Hector Valdivia (University of Wisconsin, Madison, WI)
"RyR and signaling"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:58 pm William Louch (Oslo University, Norway)
"SERCA-KO and Ca dynamics"
8:58 pm - 9:05 pm Discussion
9:05 pm - 9:23 pm Kat Dibb (University of Manchester, UK)
"Atrial remodeling in heart failure"
9:23 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Importance of Location in Signaling
Discussion Leaders: Yibin Wang (UCLA, Los Angeles, CA) and TBA (Junior Investigator)
9:00 am - 9:25 am David Kass (Johns Hopkins, Baltimore, MD)
"Localized Redox signaling and heart failure"
9:25 am - 9:35 am Discussion
9:35 am - 9:53 am Niall Macquaide (University of Leuvin, Belgium)
"Localized Ca Signaling"
9:53 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Christian Soeller (University of Aukland, NZ)
"Localized Ca signaling"
10:55 am - 11:05 am Discussion
11:05 am - 11:30 am Daria Mochly-Rosen (Stanford University, Stanford, CA)
"The importance of localization in designing clinical trials"
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm TBA (Selected from abstracts)
12:05 pm - 12:15 pm Discussion
12:15 pm - 12:25 pm TBA (Selected from GRS)
12:25 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Keynote Lecture
Discussion Leaders: Jeff Molkentin (Cincinnati Children's, OH) and TBA (Junior Investigator)
7:30 pm - 8:30 pm Rosario Rizzuto (University of Padua, Italy)
"The Mitochondrial Ca2+ Uniporter: New Insights on Ca2+ Regulation"

10 Jun - 15 Jun 2012
New london
United States of America
meeting website