Chemotactic Cytokines

Chemotactic Cytokines 2012 will be our 10th GRC. This is a good juncture to look back and commemorate a series of unforgettable meetings, all marking significant milestones of the extraordinary journey in time by the molecules of our dreams, chemokines. From their humble beginnings on the fringes of experimental research as a couple of leukocyte chemoattractants, chemokines became one of the largest families of coherently functioning, versatile intercellular signals, studied now by the cutting edge mainstream molecular science and medicine. It is currently clear that chemokine activities contribute to almost every aspect of our biological existence, starting with the moment of our conception, through months of intrauterine confinement; protecting us during the years of growth, health and wellbeing, only to push us later on, along the countless avenues of diseases, ultimately into the grave. As much as it is almost impossible to encompass the breadths of all chemokines’ activities, it became also impossible to cover all the aspects of contemporary chemokine research, even at a comprehensive conference, such as GRC. Instead of attempting this, Chemokine GRC 2012 for the first time will have a specific thematic focus, also reflected in its title, Chemotactic Cytokines: Molecular and Cellular Mechanisms in Health and Disease. This means that, rather than restricting in any way the breadth of chemokine implications covered, our GRC will concentrate primarily on their most fundamental, mechanistic aspects.

The research on chemokines has considerably accelerated and spread from initially few principal centers to thousands of institutions worldwide. Hence, nowadays it is hard to predict ahead of time in which laboratories the hottest and the coolest chemokine discoveries of 2012 will emerge. In anticipation of such discoveries and to conform with the spirit of the Gordon Conference, calling to showcase cutting edge unpublished data, we allocated even more speaker slots to the late breaking and short talks selected from abstracts. These should complement invited lectures by top scientists covering biochemistry of chemokines and the cellular responses to them, in vitro and in vivo mechanisms of chemokine induced migration, chemokines in immune organogenesis and immune organ function, chemokines in infection and immunity and the contribution of chemokines to the disease pathogenesis, including cancer.

During the last several years a new generation of young scientists joined the research on chemokines. Students and post-docs constitute now the most numerous group of Chemokine GRC participants. The traditional GRC format provided for their top notch and broad ex cathedra education, but not necessarily fostered their most active participation. This hiatus was addressed and, with considerable pride and excitement, we are announcing that Chemokine GRC 2012 will be twinned for the first time with the Chemokine Gordon Research Seminar, a satellite meeting for young bench scientists, post docs and students, which will take place May 26-27, 2012. This meeting will allow young chemokine researches to interact in an informal setting, exchange ideas, gain confidence as speakers and achieve higher personal visibility. Moreover, it will provide a forum for their concerted mentoring by the most outstanding chemokine scientists.

Our GRC will be returning to Il Ciocco, resort tucked away amidst Toscana Mountains, in the heart of a fascinating land, rich in history and culture, warm, hospitable and welcoming. Despite Il Ciocco being not only one of the most beautiful, but also largest GRC venues, its capacity is finite and only first 200 registered participants will be able to attend the Chemokine GRC, 2012. Our last GRC was oversubscribed with long waiting lists and considerable disappointment for those at end of the queue who could not attend. To assure your participation please register early!

We look forward to seeing you in Il Ciocco in May 2012 and hope that the combination of cutting edge science, passionate scientific debate and relaxing atmosphere of Il Ciocco will be conducive of a successful meeting!

Antal Rot and Andy Luster

+ show speakers and program
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:45 pm Welcome / Introductory Comments by GRC Site Staff
7:45 pm - 8:00 pm Welcome / Introductory Comments by Conference Chair, Antal Rot
8:00 pm - 9:15 pm Keynote Session
Discussion Leader: Antal Rot (University of Birmingham)
8:00 pm - 9:00 pm Uli von Andrian (Harvard Medical School)
"Imaging anti-viral immunity"
9:00 pm - 9:15 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Mechanisms in Leukocyte Migration, Recruitment and Mobilization
Discussion Leader: Bernhard Moser (Cardiff University)
9:00 am - 9:20 am Paul Kubes (University of Calgary)
"Chemokines in the hierarchies of migratory signals"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Michael Sixt (Institute of Science and Technology-Austria)
"Interpretation of chemokine gradients in vivo"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Ronen Alon (Weizmann Institute of Science)
"Chemotactic cues for lymphocyte migration"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Group Photo / Coffee Break
10:50 am - 11:10 am Klaus Ley (La Jolla Institute for Allergy and Immunology)
"Differential signaling for chemokine-induced integrin activation and chemotaxis"
11:10 am - 11:20 am Discussion
11:20 am - 11:40 am Sara Rankin (Imperial College)
"Trafficking of leukocytes, stem cells and megakaryocytes in and out of the bone marrow"
11:40 am - 11:50 am Discussion
11:50 am - 12:00 pm TBA (Short Talk)
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pm TBA (Short Talk)
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Bernhard Moser (Cardiff University)
"Concluding Remarks"
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Chemokines in Disease 1
Discussion Leader: Barrett Rollins (Harvard Medical School)
5:30 pm - 5:50 pm Richard Ransohoff (Cleveland Clinic)
"Leukocyte- endothelial interactions at the BBB: Go with the flow"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Christian Weber (Ludwig-Maximilians University, Munich)
"Chemokines in vascular disease"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm David Adams (University of Birmingham)
"Chemokines in liver disease"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:15 pm TBA (Late Breaking Talk)
7:15 pm - 7:20 pm Discussion
7:20 pm - 7:30 pm Barrett Rollins (Harvard Medical School)
"Concluding Remarks"
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Chemokines in Immunity & Infection
Discussion leader: Phil Murphy (NIH)
9:00 am - 9:20 am Andy Luster (Massachusetts General Hospital)
"Chemokine control of T cell migration in homeostasis and inflammation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Federica Sallusto (Institute for Research in Biomedicine)
"Functionally distinct subsets of human memory T cells identified by chemokine receptor expression"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Daniel Campbell (Benaroya Research Institute)
"Control of regulatory T cell specialization"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:00 am TBA (Short Talk)
11:00 am - 11:05 am Discussion
11:05 am - 11:15 am TBA (Short Talk)
11:15 am - 11:20 am Discussion
11:20 am - 11:40 am Jean Lim (Mount Sinai School of Medicine)
"CCR5 and the susceptibility to West Nile virus/flavivirus infection"
11:40 am - 11:50 am Discussion
11:50 am - 12:10 pm Martine Smit (Vrie University Amsterdam)
"The biology of viral chemokine receptors"
12:10 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Phil Murphy (NIH)
"Concluding remarks"
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Biochemistry of Chemokines
Discussion Leader: Amanda Proudfoot (Merck Serono Geneva Research Centre)
5:30 pm - 5:50 pm Tracy Handel (University of California Berkeley)
"Insights into chemokine interactions with receptors and glycosaminoglycans"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Brian Volkman (Medical College of Wisconsin)
"Biased agonism and structure-based inhibition of CXCR4 signaling"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Andreas Kungl (University of Graz)
"Profiling proteoglycans as functional chemokine co-receptors in disease"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Sofie Struyf (Rega Institute, Leuven)
"Mode of action of CXCL4L1"
7:20 pm - 7:25 pm Discussion
7:25 pm - 7:30 pm Amanda Proudfoot (Merck Serono Geneva Research Centre)
"Concluding remarks"
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Chemokines in Immune-mediated Diseases and Cancer
Discussion Leader: Alberto Mantovani (Istituto Clinico Humanitas)
9:00 am - 9:20 am Joshua Farber (NIH)
"Chemokine receptors in Th17 biology and disease"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Kouji Matsushima (University of Tokyo)
"CCR4 as a therapeutic target for the treatment of allergic diseases and T cell leukemia"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Charles Mackay (Monash University)
"CXCR7, GPR43 and GPR18 in health and disease"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:10 am Sam Hwang (Medical College of Wisconsin)
"CCR6+, IL22-producing gamma-delta T cells in psoriasiform dermatitis"
11:10 am - 11:20 am Discussion
11:20 am - 11:35 am TBA (Late Breaking Talk)
11:35 am - 11:40 am Discussion
11:40 am - 11:55 am TBA (Late Breaking Talk)
11:55 am - 12:00 pm Discussion
12:00 pm - 12:10 pm TBA (Short Talk)
12:10 pm - 12:15 pm Discussion
12:15 pm - 12:30 pm Alberto Mantovani (Istituto Clinico Humanitas)
"Concluding remarks"
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Chemokines in Cancer
Sergio Lira (Mount Sinai School of Medicine)
5:30 pm - 5:50 pm Jeffrey Pollard (Albert Einstein College of Medicine)
"Macrophages recruited by chemokines promote tumor cell extravasation and metastatic growth"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Amnon Peled (Hadassah-Hebrew University)
"Role of CXCR4 in cancer development and progression"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Tom Schall (Chemocentryx)
"Chemokine receptors and interceptors in cancer"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:15 pm TBA (Late Breaking Talk)
7:15 pm - 7:20 pm Discussion
7:20 pm - 7:30 pm Sergio Lira (Mount Sinai School of Medicine)
"Concluding remarks"
7:30 pm - 8:00 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Immune Tissues: Structure & Function
Albert Zlotnik (University of California Irvine)
9:00 am - 9:50 am Keynote Lecture: Jason Cyster (University of California San Francisco)
"Oxysterols and chemokines guide the B cell immune response"
9:50 am - 10:00 am Discussion
10:00 am - 10:20 am Graham Anderson (University of Birmingham)
"Intrathymic migration and the selection of developing T-cells"
10:20 am - 10:30 am Discussion
10:30 am - 10:50 am Coffee Break
10:50 am - 11:10 am Reinhold Forster (Hannover Medical School)
"Beyond antigen presentation: The role of dendritic cells in T cell lymph node homeostasis"
11:10 am - 11:20 am Discussion
11:20 am - 11:40 am Reina Mebius (Vrie University Amsterdam)
"The stromal cells of the immune system"
11:40 am - 11:50 am Discussion
11:50 am - 12:00 pm TBA (Short Talk)
12:00 pm - 12:05 pm Discussion
12:05 pm - 12:15 pm TBA (Short Talk)
12:15 pm - 12:20 pm Discussion
12:20 pm - 12:30 pm Albert Zlotnik (University of California Irvine)
"Closing remarks"
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Atypical Chemokine Receptors
Discussion Leader: Rob Nibbs (University of Glasgow)
5:30 pm - 5:50 pm Gerry Graham (University of Glasgow)
"D6 in the coordination of innate and adaptive immune responses"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:20 pm Marcus Thelen (Institute for Research in Biomedicine)
"Expression and function of CXCR7 in B cells"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:50 pm Silvano Sozzani (University of Brescia)
"Regulation of leukocyte trafficking by CCRL2"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:20 pm Massimo Locati (University of Milan)
"Mechanisms of Interceptor signalling"
7:20 pm - 7:25 pm Discussion
7:25 pm - 7:30 pm Rob Nibbs (University of Glasgow)
"Concluding remarks"

27 May - 1 Jun 2012
Lucca
Italy
meeting website