Cyclic Nucleotide Phosphodiesterases

The cyclic-nucleotides cAMP and cGMP are intracellular chemical signals that control most aspects of cellular behavior. These so-called "second messenger" responsive pathways have long been considered therapeutic targets for the treatment of cardiovascular and inflammatory airway diseases and neuropsychiatric disorders. The 2012 Gordon Conference on Cyclic Nucleotide Phosphodiesterases will convene in Il Ciocco Italy from May 20-25, 2012. This 8th meeting in the series will provide a forum for investigators from academia and industry to present cutting-edge research and ponder the latest concepts in molecular and cellular cyclic nucleotide metabolism and cell signaling. The opening session of the meeting will set the scene with lectures from three renowned experts in cyclic nucleotide signaling. Pharmacological intervention of second messenger responses as therapies for a variety of pathophysiological disorders will be a featured topic of discussion. The scientific program will also feature a range of lectures that explore the structural biology of phosphodiesterases, the spatial organization of cAMP/cGMP effector molecules, genetic manipulation of phosphodiesterases and the pathophysiolgical implications of defective cyclic nucleotide signaling. The keynote lecture will be delivered by Dr. Johannes L. Bos on the interface of cAMP and cancer signaling pathways. The organizers encourage junior scientists and graduate students to attend. Delegates should submit an abstract of their research for poster presentation and selected individuals will be invited to give short talks on emerging aspects of cyclic nucleotide research. The collegial atmosphere of this conference, with discussion sessions and informal gatherings in the afternoons and evenings, creates an optimal environment for scientists from different disciplines to interact.
+ show speakers and program
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Cyclic Nucleotide Signaling Pathways: From Impulse to Target
Discussion Leader: TBA
7:45 pm - 8:10 pm Carmen Dessauer (University of Texas Medical School, Houston, TX)
"Facilitation of cAMP Signaling by Anchored Adenylyl Cyclase Complexes"
8:10 pm - 8:20 pm Discussion
8:20 pm - 8:45 pm Susan Taylor (University of California San Diego, CA)
"Dynamic Regulation and Localization of PKA"
8:45 pm - 8:55 pm Discussion
8:55 pm - 9:20 pm Manuela Zaccolo (University of Oxford, UK)
"PDEs and local control of cAMP signal in cardiac myocytes"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm The Physiology of Cyclic Nucleotide Action
Discussion Leader: Nicholas Brandon (Psychiatry Research at Pfizer, Princeton, NJ)
9:05 am - 9:30 am Marco Conti (UCSF, San Francisco, CA)
"PDE4 and regulation of beta adrenergic signaling"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 am TBA (Short Talk)
9:50 am - 9:55 am Discussion
9:55 am - 10:20 am Stanley C. Froehner (University of Washington, Seattle, WA)
"Compartmentalized Nitric Oxide-cGMP Signaling in Skeletal and Cardiac Muscle"
10:20 am - 10:30 am Discussion
10:30 am Group Photo / Coffee Break
11:00 am - 11:25 am Alexander Pfeifer (University of Bonn, DE)
"Differential roles of cGMP and cAMP in fat"
11:25 am - 11:35 am Discussion
11:35 am - 11:45 am TBA (Short Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:15 pm TBA
12:15 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Therapeutic Intervention of Phosphodiesterase Signaling 1
Discussion Leader: Miles Houslay (University of Glasgow, UK)
5:35 pm - 6:00 pm Rick H. Cote (University of New Hampshire, Durham, NH)
"Mapping the interaction surface of PDE6 with its binding partners"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm TBA (Short Talk)
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:50 pm Geert Jan Sterk (Mercachem, Nijmegen, NL)
"Selective inhibitors of TbrPDEB1: A novel treatment for African trypanosomiasis"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:25 pm TBA
7:25 pm - 7:30 pm Discussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Temporal and Spatial Resolution of Second Messenger Signaling
Discussion Leader: Manuela Zaccolo (University of Oxford, UK)
9:05 am - 9:30 am Richard Marais (Institute of Cancer Research, London, UK)
"From BRAF and RAS signalling to therapeutics in melanoma"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 am TBA (Short Talk)
9:50 am - 9:55 am Discussion
9:55 am - 10:20 am Emilio Hirsch (University of Torino, IT)
"cAMP and PIP3 at a crossroad in the heart"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Benjamin Kaupp (Research Centre Caesar, Bonn, DE)
"Sperm chemotaxis - a cGMP-signaling pathway with single-molecule sensitivity"
11:25 am - 11:35 am Discussion
11:35 am - 11:45 am TBA (Short Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:15 pm Miles Houslay (University of Glasgow, UK)
"Dynamic regulation of PDE4 by multi-site phosphorylation"
12:15 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Metabolic Control and Local Second Messenger Signaling
Discussion Leader: Vince Manganiello (NIH, Bethesda, MD)
5:35 pm - 6:00 pm Sven Enerb├Ąck (Gothenburg University, SE)
"Metabolically active brown adipose tissue in healthy adult humans"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm TBA (Short Talk)
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:50 pm Brian A. Hemmings (Friedrich Miescher Institute for Biomedical Research, Basel, CH)
"Regulation of Epithelial-mesenchymal Transition and Cancer Metastasis by PI3K/PKB Signaling"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:25 pm George S. Baillie (University of Glasgow, UK)
"A novel point of crosstalk between the cAMP and ERK Mapkinase signalling pathways"
7:25 pm - 7:30 pm Discussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm PDE Pharmacology and Cardiovascular Control
Discussion Leader: Marco Conti (UCSF, San Francisco, CA)
9:05 am - 9:30 am Joseph Beavo (University of Washington, Seattle, WA)
"Roles for PDE8 in regulation of cellular function"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 am TBA (Short Talk)
9:50 am - 9:55 am Discussion
9:55 am - 10:20 am David A. Kass (John Hopkins Hospital, Baltimore, MD)
"Cardiac myocyte stress modulation by PDEs: Multiple players, multiple compartments"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Donald Maurice (Queen's University, Kingston, ON, Canada)
"Compartment specific cyclic nucleotide signaling and control of mural cell vascular functions"
11:25 am - 11:35 am Discussion
11:35 am - 11:45 am TBA (Short Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:15 pm TBA
12:15 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:30 pm Free Time
4:30 pm - 6:00 pm Poster Session
6:00 pm - 7:30 pm Keynote Lecture: Cyclic Nucleotide Signaling by Small G Proteins
6:00 pm - 7:15 pm Johannes L. Bos (Utrecht University, NL)
"Epac as spatiotemporal control units in cAMP signaling"
7:15 pm - 7:30 pm Discussion
7:30 pm - 8:00 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Therapeutic Intervention of Phosphodiesterase Signaling 2
Discussion Leader: James M. O'Donnell (West Virginia University, Morgantown, WV)
9:05 am - 9:30 am Nicholas Brandon (Psychiatry Research at Pfizer, Princeton, NJ)
"Understanding PDE10A Inhibition for the Treatment of Schizophrenia"
9:30 am - 9:40 am Discussion
9:40 am - 9:50 am TBA (Short Talk)
9:50 am - 9:55 am Discussion
9:55 am - 10:20 am Lawrence P. Wennogle (Intra-Cellular Therapies Inc, NY)
"Phosphodiesterase 1 Mechanisms Implicated in Disorders of the Central Nervous System"
10:20 am - 10:30 am Discussion
10:30 am Coffee Break
11:00 am - 11:25 am Martin Gunthorpe (biocrea GmbH, Radebeul, DE)
"Dualing with PDE10/2 inhibitors to combat unmet medical need in schizophrenia"
11:25 am - 11:35 am Discussion
11:35 am - 11:45 am TBA (Short Talk)
11:45 am - 11:50 am Discussion
11:50 am - 12:15 pm Vahri Beaumont (CHDI Foundation, Los Angeles, CA)
"Opportunities for Huntington's Disease therapeutics and PDE inhibition"
12:15 pm - 12:25 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm Cyclic Nucleotide Signaling and Pathophysiology
Discussion Leader: Jackie D. Corbin (Vanderbilt Univ Medical Center, Nashville, TN)
5:35 pm - 6:00 pm Doris Koesling (Ruhr University Bochum, DE)
"PDEs involved in NO/cGMP mediated effects"
6:00 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm TBA (Short Talk)
6:20 pm - 6:25 pm Discussion
6:25 pm - 6:50 pm Finn Olav Levy (University of Oslo, NO)
"PDE-mediated crosstalk between cGMP and cAMP in normal and failing hearts"
6:50 pm - 7:00 pm Discussion
7:00 pm - 7:25 pm Rodolphe Fischmeister (University of Paris-Sud 11, FR)
"PDE4 and cardiac excitation - contraction coupling"

20 May - 25 May 2012
Lucca
Italy
meeting website