Glycobiology and glycochemistry: Applications to human health and disease

Very recently, by expanding the knowledge of modern molecular biology and medicine, Glycosciences have become more vibrant. At long last, the importance of glycans in biological processes has started to be appreciated. Glycosciences provides us with solutions and offer tools for demanding health problems.
Glycobiology and Glycochemistry are the two main and intertwined areas of Glycosciences, dealing with various aspects of glycans, including carbohydrate structure, biochemistry, biological functions and applications. This EMBO Workshop aims to instigate the creation of “scientifically bilingual” investigators fluent in glycan chemistry and biology. This is necessary in order to sustain and advance the identification of key glycobiological aspects and the application of Glycans and Glycoengineering strategies in the design of novel therapies to improve human health. close
At the end of this EMBO Workshop, the participants should be able to discuss distinct scientific subjects within the scope of Glycosciences.
Themes covered will include:
Glycochemistry
Glycans in human physiological mechanisms
Glycans and Cancer
Congenital Disorders of Glycosylation
Biosynthesis of disease related carbohydrate antigens
Methods in Glycosciences

Lectures:
The workshop includes easy-to-understand lectures, provided by scientists and renowned professors working in Glycosciences. Lectures are focused on the modern knowledge, methods and applications in Glycosciences and aim to encourage discussion among participants. An e-learning platform with video recorded lectures will also be available for students to get in-depth information about Glycobiology and Glycochemistry.
Selected Presentations:
It also includes Oral presentations (10 minutes + 5 minutes discussion) selected from early stage researchers and students. Ample time is provided for discussions both formally after the presentations but also in an informal atmosphere during the workshop.
Posters:
A poster sneak preview and two poster sessions are included in the workshop. The posters will be available for viewing throughout the entire meeting.
Workgroups:
In a group participants will be asked to discuss research articles related with Glycosciences and then to prepare a small presentation at the end of the workshop. The presentations will be supervised by teachers and evaluated by everyone.
During the Workshop:
Participants are encouraged to approach speakers to discuss topics related with the workshop and may request private meetings. During one lunch, the participants will have the chance to select a teacher to share a table. A poster quiz game and prize will be held to promote interaction between poster presenters and all participants.
+ show speakers and program
PRELIMINARY PROGRAMME
SATURDAY MAY 24
12:00 – 15:00
Registration

15:00 – 16:00
Poster sneak preview

16:00 – 17:00
Paula Videira / OPENING LECTURE “Introduction to Glycobiology”

17:00 – 18:00
LECTURE Amélia Pilar Rauter “Introduction to Glycochemsitry”

18:00 – 19:00
LECTURE Anne Dell "Sugars and recognition: glycomic and glycoproteomic strategies”

19:00 – 19:30
“Course details, overview of syllabus and evaluation. Presentation of the work groups and distribution of the themes”

19:30 -
Welcome buffet at Sala dos Passos perdidos, Faculdade de Ciências Médicas. A momento of Portuguese History
SUNDAY MAY 25

Session: Glycochemistry

9.00 – 10:00
LECTURE Serge Perez Molecular modelling in glycoscience

10:00 – 10:30
Coffee Break

10:30 – 11:30
LECTURE Antoni Planas "Glycoside hydrolases as synthetic tools in Glycochemistry"


Session: Biosynthesis of disease related carbohydrate antigens

11:30 – 12:30
LECTURE Stefan Oscarson
Carbohydrate chemistry and the development of carbohydrate-based vaccines and drugs

12:30 – 14:30
Lunch

14:30 – 15:30
LECTURE Richard Schmidt "Glycoside bond formation - Can chemists learn from nature?"

15:30 – 16:30
Poster Session

16:30 – 17:00
Coffee Break

17:00 – 19:00
Work Groups / Tutorials
MONDAY MAY 26

Session: Glycans in human physiological mechanisms

9.00 – 10:00
LECTURE Joseph Lau “Extracellular Glycosyltransferases as Systemic Regulators of Blood Cell Development and Function”

10:00 – 10:30
Coffee Break

10:30 – 11:30
LECTURE – Yvette Van Kooyk
Immune stimulatory and inhibitory glycans that regulate Dendritic cell immune responses

11:30 – 12:30
LECTURE – Michaela Wimmerova
Lectins from pathogens and their recognition of host glycans

12:30 – 14:30
Lunch students and speakers


Session: Glycans and Cancer

14:30 – 15:30
LECTURE – Fabio Dall’Olio "Mechanisms of cancer-associated glycosylation changes.”

15:30 – 16:30
Poster Session

16:30 – 17:00
Coffee Break

17:00 – 18:00
Oral Presentation from selected abstracts from young investigators (10 minutes + 5 minutes discussion)

18:30 – 20:30
Walking in Lisbon downtown / sunset over the Tagus river
TUESDAY MAY 27




Session: Glycans and Cancer (cont.)

9.00 – 10:00
LECTURE Marco Trinchera "The problematic origin of circulating CA19.9 antigen"


Session: Congenital Disorders of Glycosylation

10:00 – 10:30
Coffee Break

10:30 – 11:30
LECTURE / Dirk Lefeber “CDG-I and CDG-II defects”

11:30 – 13:00
PRATICAL / Dirk Lefeber CDG pratical course




13:00 – 14:00
Lunch

14:30 – 16:00
PRATICAL LECTURE Dirk Lefeber
CDG pratical course

16:00 – 16:30
Coffee Break

16:30 – 17:30
Group Discussions

17:30 – 18:30
Oral Presentation of selected abstracts from young researchers/ Posters (10 minutes + 5 minutes discussion)

18:30 - 19:30
Meetings between students and teachers

19:30
– GALA DINER with Fado, a moment of Portuguese culture.
WEDNESDAY MAY 28




Session: Methods in Glycosciences

9.00 – 10:00
LECTURE Hans Wandall
Use of nuclease gene targeting for functional glycomics.

10:00 – 10:30
Coffee Break

10:30 – 11:30
LECTURE Angelina Palma "Glycan microarrays to decipher roles for glycans, challenging molecules of life"

11:30 – 12:30
LECTURE Alexandre Ferreira and Rui Vitorino "Analytical methods in glycomics and glycoproteomics”

12:30 – 14:00
Lunch

14:00 – 16:00
Group Presentations and Discussions

16:00 – 16:30
Coffee Break

16:30– 18:30
Group Presentations and Discussions


COLLOQUIUM - Conclusive thoughts and final discussion, distribution of certificates


Social Event

24 May - 28 May 2014
Lisbon
Portugal
meeting website