Cellular signalling and cancer therapy

This EMBO Conference focusing on cancer biology and therapy follows the successful series of three EMBO Conferences on cellular signalling and molecular medicine.
The processes involved in cancer initiation and progression are highly complex, and a detailed knowledge of the involved mechanisms at molecular, cellular and organismal level is needed to improve both diagnostic tools and patient treatment. Genomic and post-genomic/proteomic technologies have not only delivered a wealth of information about the complex networks underlying carcinogenesis, but at the same time broke the ground for new strategies in developing modern anti-cancer treatments. This EMBO Conference brings together leading experts from different scientific disciplines to discuss new findings and future challenges in cancer research.
The programme will focus on the following topics:
molecular cancer therapeutics
oncogenic signalling networks
cancer metastasis
cell metabolism and cancer development
role of inflammation in cancer progression
involvement of cell death and autophagy pathways in cancer pathogenesis
molecularly-targeted therapies
A key goal of this EMBO Conference is to promote the education of young scientists and catalyze constructive scientific interactions among participants via lectures, poster presentations, selected talks and informal discussions. In addition to the invited speakers, there will be selected presentations from younger scientists and active poster sessions. Two poster prizes (€250 each) are funded by the European Association for Cancer Research to award outstanding contributions to the sessions. Two further poster prizes are funded by EMBO Journal and EMBO reports, both comprise of vouchers of €200 each, to be redeemed at any EMBO Workshop, Conference or Practical Course.
+ show speakers and program
FRIDAY MAY 23, 2014
16.00
Arrival and registration
18.00-18.10
Welcome words
Ivan Dikic, Goethe University Frankfurt, Germany
18.00-18.45
Keynote Lecture 1 Seven Transmembrane Receptors
Bob Lefkowitz, Duke University, USA
18.50-19.25
Keynote Lecture 2: Receptor Tyrosine Kinases; Mechanism of Activation and Cancer Therapy
Joseph Schlessinger, Yale, USA
19.30-20.10
Keynote lecture 3 – in Memory of Tony Pawson
Guiding Signals through Anchored Enzyme Complexes
John Scott, University of Washington, USA
20:15
Welcome Dinner
SATURDAY MAY 24, 2014
Session II Oncogenic Signalling networks I
Chair: John Scott
09.00-09.35
Keynote lecture 4: Targeting K-Ras driven tumors
Mariano Barbacid, Centro Nacional de Investigaciones Oncológicas (CNIO), Spain
09.40-10.10
Tyrosine kinase signalling networks in human cancer
Roger Daly, Monash University, Australia
10.15-10.35
Ubiquitin dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by IAPs
Krishna Rajalingham, Mainz University, Germany
10.40-11.10
Tea Break
11.15-11.40
Novel targets of Raf in tumorigenesis
Manuela Baccarini, Max F. Perutz Laboratories (MFPL), Austria
11.45-12.15
BRAF and RAS signalling in melanoma: basic biology and therapeutic options
Richard Marais,Cancer Research UK Manchester Institute, UK
12.20-12.30
Selected talk 1
12.30-12.40
Selected talk 2
12.40-12.50
Selected talk 3
13.00-14.30
Lunch Break
Session III Genomic integrity in cancer
Chair: Ruth Palmer
14.30-15.05
Keynote lecture 5: Harnessing Genetic Dependencies in Cancer Therapy
Alan Ashwort, The Institute of Cancer Research (ICR), UK
15.10-15.40
Histidine phosphorylation: the invisible phosphoproteome?
Tony Hunter, Salk Institute Cancer Center, USA
15.45-16.05
Comprehensive genomic analysis of human tumors identifies oncogenic drivers
Somasekar Seshagir, Genentech, USA
16.10-16.40
Tea Break
16.40-17.10
Control of DNA repair activity at mammalian telomeres
Jacqueline J. Jacobs, Netherlands Cancer Institute, The Netherlands
17.15-17.45
Signalling a cell cycle exit after radiation therapy
René Medema, Netherlands Cancer Institute, The Netherlands
17.50-18.00
Selected talk 4
18.00-18.10
Selected talk 5
18.10-18.20
Selected talk 6
19.00-23.00
Poster session (odd numbers)

Fingerfood Dinner

SUNDAY MAY 25, 2014
Session III Oncogenic Signalling II
Chair: Manolis Pasparakis
09.00-09.35
Keynote lecture 5:
Survival and Vascular Co-option of Metastasis Initiating Cells
Joan Massague, Memorial Sloan Kettering Cancer Center, USA
09.40-10.15
Focal adhesion kinase signalling and cancer immune evasion
Margaret Frame, Edinburg University, UK
10.20-10.40
Targeting Signal Transduction for the Treatment of Acute Myeloid Leukemia
Hubert Serve, Goethe University Frankfurt, Germany
10.40-11.10
Tea Break
11.10-11.40
Rap signalling complexes: landmark recognizing modules in cell adhesion and polarity
Hans Bos, Utrecht University, Netherlands
11.45-12:15
Tumor Suppressor role for the deubiquitinase, BAP1
Vishva Dixit, Genentech, USA
12.20-12.30
Selected talk 7
12.30-12.40
Selected talk 8
13.00-15.00
Poster session (even numbers)
Fingerfood lunch
15.15
Excursion (Dinner not included)

MONDAY MAY 26, 2014
Session IV Inflammation and cancer
Chair: Rene Medema
09.00-09.35
Keynote lecture 7:
Regnase-1-mediated regulation of the immune response
Shizuo Akira, Osaka University, Japan
09.40-10.10
IKK/NF-kB signalling in inflammation and cancer
Manolis Pasparakis, University of Cologne, Germany
10.15-10.45
Targeting Inflammatory Cytokines and Chemokines
Frances Balkwill, Cancer Research UK, Queen Mary University of London, UK
10.50-11.20
Tea Break
11.20-11.50
The EGFR - exploring the unexpected
Maria Sibilia, Medical University of Vienna, Austria
11.55-12.25
A Numb/p53 circuitry couples control of replicative self-renewal and tumour suppression in normal and cancer mammary epithelial cells
Pier Paolo Di Fiore, Istituto FIRC di oncologia molecolare (IFOM), Italy
12.30-12.50
Molecular basis for engineering myeloid suppressors
Peter Murray, St. Jude Children's Research Hospital, USA
13.05-14.30
Lunch
Session V Oncology pathways in cancer metabolism and development
Chair: Margaret Frame
14.30-15.05
Keynote lecture 7:
Signalling in wound-induced skin cancer
Fiona Watt, University of Cambridge, UK
15.10-15.40
Anaplastic Lymphoma Kinase signalling in Drosophila and mouse models
Ruth Palmer, Umea University, Sweden
15.45-16.15
Tea Break
16.15-16.45
Structural regulation of ubiquitin pathways
Brenda Schulman, St. Jude Children's Research Hospital, USA
16.50-17.20
Mitotic Wnt signaling regulates cell growth and proliferation
Christof Niehrs, Institute for Molecular Biology (IMB), Germany
17.25-17.45
The function of p63 and p73 in genetic quality control and cancer development
Volker Dötsch, Goethe University Frankfurt, Germany
18.00-20.00
Poster session (even numbers)
20.30-23:30
Farewell dinner and dancing
TUESDAY MAY 27, 2014
Session VI Cell death and autophagy pathways
Chair: Maria Sibila
09.00-09.35
Keynote Lecture 9:
Life and Death Decisions: Annexin AI expressed on apoptotic cells downregulates the immune response
Peter Krammer, German Cancer Research Center (DKFZ), Germany
09.40-10.10
Caspase-2 as a tumour suppressor
Sharad Kumar, Centre for Cancer Biology (CCB), Australia
10:15-10:25
Selected talk 9
10:25-10:35
Selected talk 10
10.35-11.05
Tea Break
11.05-11.35
Keynote lecture 10:
Autophagy in cancer
Yoshinori Ohsumi, Tokyo Institute of Technology, Japan
11.45-12.15
Autophagy in haematological tumors
Katharina Simon, University of Oxford, UK
12.20-12.50
Autophagy: Friend or foe in the treatment of fusion protein-associated leukemias?
Anne Simonsen, University of Oslo, Norway
12.55-13.10
Poster award ceremony and closing remarks
13:15-14.30
Lunch break

Departure

23 May - 27 May 2014
Cavtat
Croatia (Hrvatska)
meeting website