23rd Annual Short Course on Experimental Models of Human Cancer

The Jackson Laboratory presents this graduate-level genetics course for predoctoral and postdoctoral students as well as established investigators entering the field of mouse genetics. The course focuses on the mouse as an experimental tool in cancer research.

Workshops will include: mouse genome informatics, laboratory animal biomethods (optional), gross pathology, necropsy and tumor histo-pathology. The intensive course offers a mix of formal lectures, discussion groups, demonstrations, workshops and tutorials. The course is held in a retreat-like setting and is limited to 35 participants to ensure a supportive learning atmosphere with exceptional interaction between students and faculty.

Topics include(preliminary list):

Genetics of the laboratory mouse
Tools for genetic analysis
Developmental genetics and cancer
Genetic models in cancer research
Genetics of inbred mouse strains
Spontaneous/induced mutants
Lab animal husbandry
Genetic mapping, physical mapping
Candidate gene identification
Statistical genetics
Complex trait analysis
Gene expression analysis
Strategies in induced mutagenesis
Bio-informatics in genetics and genomics
Development, growth control and malignancy
Mouse models for cancer research
+ show speakers and program
The 2014 event schedule is being developed and will be posted as soon as possible.

In the meantime, please view the 2013 event schedule for an idea of course content and structure.


Friday, August 23

12:30 PM Arrival at Highseas anytime after 12:30 PM

Location – Highseas Conference Room – 3
rd
Floor


5:00 Course Evaluations
Brian Doore, M.S., University of Maine, Center for Research and Evaluation

5:15 History of The Jackson Laboratory in Cancer Research
Barbara Knowles, Ph.D., IMB/A*STAR, Singapore


6:00 Reception - Highseas Lobby

6:30 Dinner – Highseas Dining Room

Saturday, August 24 (Highseas and GRB Training Lab)

7:00 – 8:00am Breakfast – Highseas

Location – Highseas Conference Room – 3rd Floor

BACKGROUND SESSIONS

8:20 AM Pathology and histopathology of normal and neoplastic tissue: an
overview Rosalinda Doty, D.V.M., The Jackson Laboratory

9:30 Group A - Colony management workshop

Location – Highseas Conference Room – 3
rd
Floor


9:30 Mouse Genetics and Strain Nomenclature: What’s in a Name?
Jennifer Corrigan, M.S., The Jackson Laboratory

10:15 Practical aspects of using mice in biomedical research: breeding
strategies
Marge Strobel, Ph.D. The Jackson Laboratory

11:15 Break

11:30 Practical aspects of using mice in biomedical research: Issues in Animal
Health
Peggy Danneman, V.M.D., M.S., ACLAM., The Jackson Laboratory

12:30 End of Morning Session

9:30 Group B Van Transportation to GRB Training Lab

Location: Main Lab - GRB Training Lab

9:30 Workshop: (Group B)
Pathology, Tissue Trimming, Necropsy, and Perfusion
James Miller , The Jackson Laboratory
Mike McCluskey, The Jackson Laboratory


12:45 PM Group B Van Transportation to Highseas

12:45 PM Lunch Highseas Dining Room

1:30 Group B - Colony management workshop (Group B)

Location – Highseas Conference Room – 3
rd
Floor

1:30 Mouse Genetics and Strain Nomenclature: What’s in a Name?Jennifer Corrigan, M.S., The Jackson Laboratory

2:15 Practical aspects of using mice in biomedical research: breeding
strategies
Marge Strobel, Ph.D. The Jackson Laboratory REVISED August 20, 2013


3:15 Break

3:30 Practical aspects of using mice in biomedical research: Issues in Animal
Health
Peggy Danneman, V.M.D., M.S., ACLAM., The Jackson Laboratory

4:30 End of Afternoon Sessions


Location: Main Lab - GRB Training Lab

1:30 Workshop: (Group A)
Pathology, Tissue Trimming, Necropsy, and Perfusion
James Miller , The Jackson Laboratory
Mike McCluskey, The Jackson Laboratory

5:00 Group A Van Transportation to Highseas

6:00 Lobster Dinner with Faculty Highseas Dining Room


Sunday, August 25

7:00 – 8:00am Breakfast - Highseas

Location – Highseas Conference Center

FUNDAMENTALS

8:30 AM Mouse Genetics
Nancy Jenkins, Ph.D., The Methodist Hospital Research Institute

9:30 Statistical Analysis & Experimental Design
Gary Churchill, Ph.D., The Jackson Laboratory

10:30 Break

11:00 The Knockout Mouse Project
Mark Moore, Ph.D, National Institutes of Health


12:00 PM Lunch – Highseas Dining Room
Discussion with day’s Faculty

STEM CELLS AND EPIGENETICS

1:30 Cloning, imprinting and reprogramming: path to the stem cells
Davor Solter, M.D., Ph.D., ., IMB/A*STAR, Duke-NUS, Singapore
2:30 Pluripotency, stem cells and epigenetic reprogramming
Rudolph Jaenisch, M.D., Whitehead Institute

3:30 Break

4:00 Cancer Epigenetics
Peter Laird, Ph.D., USC Norris Comprehensive Cancer Center

6:00 Dinner – Highseas Dining Room

Monday, August 26

7:00 – 8:00am Breakfast – Highseas

8:15 AM Van Transportation to Main Lab

Location – The Jackson Laboratory, CC Little Auditorium

CANCER RESEARCH PAST, PRESENT & FUTURE


8:30 Genomics and Cancer
Ed Liu, M.D., The Jackson Laboratory

9:30 Break

10:00 Targeting the Hedgehog pathway in cancer: From Bench to Clinic
Frederic de Sauvage, Ph.D., Genentech

11:00 A time machine: How mouse genetics of the past is shaping current
research
Neal G. Copeland, Ph.D., The Methodist Hospital Research Institute
Nancy Jenkins, Ph.D., The Methodist Hospital Research Institute

12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference
 across from the auditorium

MODELING CANCER

1:30 Modeling Human Cancers in the Mouse
Mario Capecchi, Ph.D., The University of Utah


2:30 Zebrafish Models to Dissect Human Cancer Pathways REVISED August 20, 2013

Thomas Look, M.D., Dana Farber Cancer Institute

3:30 Break

4:00 Role of P53 in Cancer
Gigi Lozano, Ph.D., MD Anderson Cancer Center

5:00 Van Transportation to Highseas

6:00 Dinner – Highseas Dining Room

Tuesday, August 27

7:00 – 8:00am Breakfast - Highseas

8:15 AM Van Transportation from Highseas to Main Lab

Location – The Jackson Laboratory, CC Little Auditorium

GENETICS & GENOMICS OF CANCERS

8:30

9:30 Sequencing the cancer genome
Elaine Mardis, Ph.D., Washington University

10:30 Break

11:00 Analyzing Genome Sequence Data
Gaddy Getz, Ph.D., Broad Institute

12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference
 across from the auditorium

1:30 Genetic Engineering – What We Can do Now – and How-
Steve Murray, Ph.D., The Jackson Laboratory

2:45 Break

3:15 Accessing genomic data through on-line resources
Gareth Howell, Ph.D., The Jackson Labortory

5:00 Van Transportation to Highseas

6:00 Lobster Dinner - Highseas Dining Room

Wednesday, August 28

7:00 – 8:00am Breakfast - Highseas

8:15 AM Van Transportation from Highseas to Main Lab

DISEASE PROGRESSION & THERAPEUTIC INTERVENTION

Location – The Jackson Laboratory, CC Little Auditorium

8:30 Mechanisms of malignant progression
Robert Weinberg, Ph.D., Whitehead Institute

10:30 Break

11:00 Causes and Consequences of microRNA Dysregulation in Cancer
Carlo M. Croce, M.D., The Ohio State University Comprehensive Cancer Center


12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conferenence across from the auditorium

1:00pm Van Transportation to Highseas

Afternoon Off – Free Time

6:00 Dinner – Highseas Dining Room

7:00pm Ethics
Raju Kucherlapati, Ph.D., Harvard Medical School


Thursday, August 29

7:00 – 8:00am Breakfast - Highseas

Location – The Jackson Laboratory, CC Little Auditorium

CANCER PATHWAYS

8:30 Personalized medicine
Raju S. Kucherlapati, Ph.D., Harvard Medical School

9:30 Tumor Angiogenesis And Microenvironment
Rakesh K. Jain, Ph.D., Harvard Medical School

10:30 Break

11:00 Proteomic approaches to identifying new cancer markers
Sam Hanash, M.D., Ph.D., M.D. Anderson Cancer Center

12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference
 across from the auditorium

PREVENTIONS & THERAPIES

2:00 Targeted therapies in Lung Cancer
Bruce Evans Johnson, M.D., Dana-Farber / Harvard Cancer Center

3:00 Novel approaches for Cancer Prevention
Cory Abate-Shen, Ph.D., Columbia University Medical Center


4:00 "Strategy for Future Anti-cancer Therapeutics: Put the Cart Before the
Horses?"
Tak Mak, Ph.D., The Campbell Family Institute for Breast Cancer Research at
Princess Margaret Hospital, UHN

5:00 Van Transportation to Highseas

6:00 Dinner - Highseas Dining Room

Friday, August 30

7:00 – 8:00am Breakfast – Highseas

8:15 AM Van Transportation to Main Lab

Location – The Jackson Laboratory, CC Little Auditorium

CANCER BIOLOGY

8:30 Harnessing transposons for cancer gene discovery
Neal G. Copeland, Ph.D., The Methodist Hospital Research Institute

9:30 Pancreatic cancer treatment strategies
David Tuveson, M.D. Ph.D., Cold Spring Harbor Laboratory

10:30 Break


11:00 Genetics & Biology of Breast Cancer
David M. Livingston, M.D., Dana-Farber Cancer Institute REVISED August 20, 2013


12:00 PM Lunch - Served in Roscoe’s
Discussion with day’s Faculty – Staff Conference
across from the auditorium

1:30 Genetic Engineering
Michael Wiles, Ph.D., The Jackson Laboratory


2:30 Mouse Models for the Analysis of the Tumor Immune Microenvironment
Jeff Pollard, Ph.D., University of Edinburgh

3:30 Break

4:00 Humanized SCID Mouse Models for Cancer Research
Lenny Shultz, Ph.D, The Jackson Laboratory

5:00 Van Transportation to Highseas

6:00 Dinner – Highseas Dining Room


Saturday, August 31

7:00 – 8:00am Breakfast - Highseas

Location – Highseas Conference Center

8:30 Viruses and cancer
Susan Ross, Ph.D., University Pennsylvania

9:30 Modeling Chromosome Instability in Cancer
Kevin Mills, Ph.D., The Jackson Laboratory

12:00 PM Lunch – Highseas Dining Room

1:00 Free Time

6:00 Dinner – Highseas Dining Room

Sunday, September 1

7:00 – 8:30am Breakfast - Highseas

Departures

16 Aug - 26 Aug 2014
Bar Harbor
United States of America
meeting website