Cytokine JAK-STAT Signaling in Immunity and Disease

Cytokines are important extracellular factors that direct a variety of biological responses in normal physiology and disease. Cytokine signaling is mediated in large part through four Janus kinase (JAK) proteins and seven Signal Transducer and Activator of Transcription (STAT) proteins, and these molecules intersect with a wide array of additional intracellular signals to drive significant global alterations in gene expression. Cytokine JAK-STAT pathways are intimately associated with innate and adaptive immunity, inflammation, stem cell and developmental biology, and diverse aspects of cancer biology. As JAK-STAT pathways produce both common and unique phenotypes critical for a vast range of biological phenomena, the basic understanding of how these signal transduction cascades are regulated, function and integrate with additional cellular responses has been continuously refined by discoveries of general and pathway-specific mechanisms. Furthermore, drug discovery efforts have produced small molecules targeting JAKs and STATs that are promising agents in clinical treatment of inflammation, arthritis and a variety of cancers. This meeting, coinciding with the 25th year of the discovery of JAK-STAT signaling, will couple invited speakers who have made significant contributions to allied disciplines with cytokine JAK-STAT veterans, with ample opportunities for short talks selected from submitted abstracts.
+ show speakers and program
Receptor Activation and STAT Signaling
Session Topics:
Workshop 1: All Things Interferon
Chromatin and Gene Regulation
Immune Regulation
Inflammation
Stem Cells and Development
Infection and Disease
Metabolic Disease and Cancer
Workshop 2: Therapeutic Targeting of JAK-STAT Pathways
Cancer Microenvironment and Therapeutics

10 Jan - 14 Jan 2016
Steamboat Springs
United States of America
meeting website