Fibroblast Growth Factors in Development & Disease

The Fibroblast growth factors (FGFs) comprise a large family of growth and differentiation factors with essential functions in development, metabolism, and repair of various tissues and organs. Dysregulation of FGF signaling is associated with a wide variety of human diseases, including several developmental/genetic diseases, metabolic disorders, and malignancies. This conference will encompass the most recent and timely research in this highly diverse field, and promote interdisciplinary interactions between scientists, clinicians and colleagues from industry studying all aspects of FGF biology. Topics will cover Biochemistry of the FGF signaling complex and control of downstream signaling pathways and their impact on cell biology, physiology, endocrinology, development, pharmacology, pathology and regeneration/repair.

In addition to presentations by invited speakers, abstracts will be selected for shorter oral presentations for each session, ensuring that the program includes a breadth of exciting new topics emerging in the period just preceding the conference.

Strong emphasis will be placed on presentation of unpublished data and extended discussion times tackling the cutting edge of the field. Poster sessions will also be given high priority. Applications will be accepted from a diverse mix of established investigators, junior PIs, postdocs and graduate students. There will also be a satellite GRS meeting for postdocs and graduate students prior to the main GRC.



+ show speakers and program
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm Keynote and Emerging/Hot Topics
Discussion Leader: Sabine Werner (ETH Zürich, Switzerland)
7:40 pm - 7:55 pm TBA (short talk selected from abstracts)
7:55 pm - 8:05 pm Discussion
8:05 pm - 8:20 pm TBA (short talk selected from abstracts)
8:20 pm - 8:30 pm Discussion
8:30 pm - 9:10 pm Keynote: Michael Brand (Technische Universität Dresden, Germany)
"Biophysical aspects of Fgf8 signaling in vivo"
9:10 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm FGFs, FGFRs and the extracellular environment
Discussion Leader: David Ornitz (Washington University School of Medicine, USA)
9:00 am - 9:25 am Moosa Mohammadi (New York University School of Medicine, USA)
"A Novel Mode of FGF Receptor Dimerization"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am TBA (short talk selected from abstracts)
9:55 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 10:50 am TBA (short talk selected from abstracts)
10:50 am - 11:00 am Discussion
11:00 am - 11:15 am TBA (short talk selected from abstracts)
11:15 am - 11:25 am Discussion
11:25 am - 11:50 am David Fernig (Liverpool University, UK)
"Exploring the Matrix with FGFs"
11:50 am - 12:05 pm Discussion
12:30 pm Group Photo / Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session I
5:30 pm - 7:30 pm FGF signaling pathways
Discussion Leader: David Fernig (Liverpool University, UK)
5:30 pm - 5:55 pm Michael Tsang (University of Pittsburgh, USA)
"Chemical approaches to dissecting the role of FGF signaling in heart development and regeneration"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm Xin Zhang (Indiana University School of Medicine, USA)
"Genetic analysis of FGF signaling in eye development"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:05 pm TBA (Selected from abstracts)
7:05 pm - 7:10 pm Discussion
7:10 pm - 7:25 pm TBA (short talk selected from abstracts)
7:25 pm - 7:30 pm Discussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Endocrine FGFs
Discussion Leader: Nobuyuki Itoh (Kyoto University, Japan)
9:00 am - 9:25 am Steven Kliewer (UT Southwestern Medical Center, USA)
"Metabolic Actions of Endocrine FGFs 15/19 and 21"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am TBA (short talk selected from abstracts)
9:55 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 11:00 am Alexei Kharitonenkov (Lilly Research Laboratories, USA)
"Novel approaches to target FGF21 pathway"
11:00 am - 11:15 am Discussion
11:15 am - 11:30 am TBA (short talk selected from abstracts)
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Yang Li (Amgen, Inc., USA)
"Novel approaches to targeting the FGF21 pathway"
12:05 pm - 12:20 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session I (continued)
5:30 pm - 7:30 pm FGFs in genetic disease, humans and models
Discussion Leader: Fen Wang (Texas A&M Health Science Center, USA)
5:30 pm - 5:55 pm Marja Hurley (University of Connecticut, USA)
"Modulation of FGF2 and FGF Receptors Expression in Aged Osteoblasts"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:25 pm TBA (short talk selected from abstracts)
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:45 pm TBA (short talk selected from abstracts)
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Nelly Pitteloud (Université de Lausanne)
"FGF21 a link between metabolism and reproduction"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm FGFs in growth control and cancer
Discussion Leader: Marja Hurley (University of Connecticut, USA)
9:00 am - 9:25 am Tomoko Iwata (Glasgow University, UK)
"Bladder cancer and the FGF signalling network"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am TBA (short talk selected from abstracts)
9:55 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 11:00 am Pamela Pollock (Queensland University of Technology, Australia)
"FGFR inhibition and the issues of intrinsic and acquired resistance"
11:00 am - 11:15 am Discussion
11:15 am - 11:30 am TBA (short talk selected from abstracts)
11:30 am - 11:40 am Discussion
11:40 am - 12:05 pm Ana Costa-Pereira (Imperial College London, UK)
"JAKs and STATs in FGF-2-mediated drug resistance"
12:05 pm - 12:20 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session II
5:30 pm - 7:30 pm FGFs and organization of development
Discussion Leader: Irma Thesleff (University of Helsinki, Finland)
5:30 pm - 5:55 pm Mark Lewandoski (NCI-Frederick, NIH, USA)
"Diverse roles of Fibroblast Growth Factor signaling during somitogenesis and axis extension"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:25 pm TBA (short talk selected from abstracts)
6:25 pm - 6:30 pm Discussion
6:30 pm - 6:45 pm TBA (short talk selected from abstracts)
6:45 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Saverio Bellusci (Justus-Liebig-Universität, Germany)
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
8:30 am - 9:00 am Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pm FGFs in the nervous system
Discussion Leader: Saverio Bellusci (Justus-Liebig-Universität, Germany)
9:00 am - 9:25 am Albert Basson (King's College London, UK)
"The importance of regulating FGF signals during development of the cerebellum"
9:25 am - 9:40 am Discussion
9:40 am - 9:55 am TBA (short talk selected from abstracts)
9:55 am - 10:05 am Discussion
10:05 am Coffee Break
10:35 am - 11:00 am Hisashi Umemori (University of Michigan, USA)
"FGF and Synapse Formation"
11:00 am - 11:15 am Discussion
11:15 am - 11:30 am TBA (short talk selected from abstracts)
11:30 am - 11:40 am Discussion
11:40 am - 12:15 pm David Ornitz (Washington University School of Medicine, USA)
"In vivo regulation of progenitor cell lineages by the FGF9/16/20 family"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session II (continued)
5:30 pm - 7:30 pm FGF signaling in repair, regeneration and therapeutics
Discussion Leader: Brad Olwin (University of Colorado, USA)
5:30 pm - 5:50 pm Sabine Werner (ETH Zürich, Switzerland)
"Mechanisms of FGF action in repair of epithelial tissues"
5:50 pm - 6:00 pm Discussion
6:00 pm - 6:15 pm TBA (short talk selected from abstracts)
6:15 pm - 6:20 pm Discussion
6:20 pm - 6:40 pm Stijn De Langhe (National Jewish Health, USA)
"Lung stem cells and their niche"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:10 pm Christoph Ladel (Merck Serono Research, Germany)
"FGF18 as specific growth factor for cartilage repair in preclinical and clinical cartilage disorders"
7:10 pm - 7:20 pm Discussion

13 May - 18 May 2012
Les Diablerets
Switzerland
meeting website