G protein-coupled receptor kinases: From molecules to diseases

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Sunday,
June 8, 2014

4:00PM – 9:00PM Conference Registration

6:00PM – 7:00 PM FASEB Opening Reception

7:00PM – 8:30 PM Dinner

8:45PM – 10:00PM Mark Caron, Duke University, Durham, NC
“Physiological roles of G protein-coupled receptor kinases”


Monday,
June 9, 2014

7:30AM – 9:00AM Breakfast

Session 1:
9:00AM – 12:15PM
GRK structure and mechanism of activation
John J Tesmer, University of Michigan at Ann Arbor

9:00AM – 9:15AM Welcome from FASEB

9:15AM - 9:45AM Speaker 1, John J Tesmer, University of Michigan at Ann Arbor,
“Mechanism of GRK activation by active G protein-coupled
receptors”

9:45AM –10:15AM Speaker 2, Vsevolod V. Gurevich, Vanderbilt University
“How arrestins decode GRK phosphorylation of GPCRs”

10:15AM – 10:30 AM Short Talk Selected From Submitted Abstracts

10:30AM – 11:00AM Group photo & FASEB Sponsored Coffee Break

11:00AM – 11:30AM Speaker 3, Rachel Sterne-Marr, Siena College
“Structural determinants of GRK2 interaction with Gαq”

11:30AM – 12:00PM Speaker 4, Tivadar Orban, Case Western Reserve University
“Mechanism of GRK1 activation”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts

12:15PM – 1:15PM Lunch

Free Afternoon

4:00PM – 6:00PM Poster Session 1

6:00PM – 7:00PM Dinner

Session 2:
7:00PM – 9:45PM
GRK function in the cardio-vascular pathology
Guido Iaccarino, Universita degli Studi di Salerno

7:00PM - 7:30PM Speaker 1, Douglas Tilley, Temple University
“GRK-dependent effects on cardiac receptor signaling”

7:30PM – 8:00PM Speaker 2, Hitoshi Kurose, Kyushu University
“GRK and heart diseases”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts

8:45PM – 9:15PM Speaker 3, Guido Iaccarino, Universita degli Studi di Salerno
“GRK2 at the shaft of the endothelial function”

9:15PM – 9:45PM Speaker 4, Robin Felder, The University of Virginia
“The role of GRK4 in the etiology of hypertension and salt
sensitivity of blood pressure”


Tuesday,
June 10, 2014

7:30AM – 9:00AM Breakfast

Session 3
9:00AM – 12:15PM
GRK regulation, expression, and degradation
Federico Mayor, Universidad Autonoma de Madrid

9:00AM - 9:30AM Speaker 1, Martin Lohse, University of Würzburg
“Regulation of GRK2 by its interaction with Raf kinase inhibitor
protein”

9:30AM –10:00AM Speaker 2, Julie Pitcher, University College London
“G protein-coupled receptor kinase 5 (GRK5) as a
transcriptional repressor”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15AM Speaker 3, Ching-Kang Jason Chen, Virginia Commonwealth
University
“The physiology of calcium-dependent interaction between
recoverin and rhodopsin”

11:15AM – 12:00PM Speaker 4, Jihee Kim, Duke University
“GRK2/3 and GRK5/6 drive distinct β-arrestin functions”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts

12:15PM – 1:15PM

1:15PM – 2:15PM
Lunch

Meet the Expert

Free Afternoon

4:00PM – 6:00PM Poster Session 2 – Optional

6:00PM – 7:00PM Dinner

Session 4:
7:00PM – 9:45PM
GRK in neuronal functions I.
Eugenia V Gurevich, Vanderbilt University

7:00PM - 7:30PM Speaker 1. Cobi J. Heijnen, University of Texas
“GRK2 regulates transition from acute to chronic pain via multiple
mechanisms”

7:30PM – 8:00PM Speaker 2, William Suo, Kansas State University
“Potential roles of GRKs in Alzheimer's pathogenesis”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts

8:45PM – 9:15PM Speaker 3, Ellen Weiss, University of North Carolina
“Regulation of GRK Phosphorylation by Light in Vertebrate Vision”

9:15PM – 9:45PM Speaker 4, Charles Chavkin, University of Washington
“Ligand directed signaling underlying opioid analgesia and
depression is mediated by GRK”


Wednesday,
June 11, 2014

7:30AM – 9:00AM Breakfast

Session 5
9:00AM – 12:15PM
GRK-dependent regulation of receptor signaling
Richard Premont, Duke University

9:00AM - 9:30AM Speaker 1, Richard Premont, Duke University
“Tissue-dependent specificity of mAChR2 regulation by GRKs”

9:30AM –10:00AM Speaker 2, Jonathan Willets, University of Leicester
“GPCR regulation by GRKs in native systems”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15AM Speaker 3, Ricardo Richardson, North Carolina Central University
“Regulation of CXCR2-mediated cellular functions by GRK6 and
AGS3”

11:15AM – 12:00PM Speaker 4, Leonard Girnita, Karolinska Institute
“Differential regulation of IGF1 signaling by GRKs”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts

12:15PM – 1:15PM Lunch

Free Afternoon

4:00PM – 6:00PM Poster Session 3 – Optional

6:00PM – 7:00PM Dinner

Session 6:
7:00PM – 9:45PM
GRK-dependent phosphorylation of non-GPCR substrates
Jeffrey L Benovic, Thomas Jefferson University

7:00PM - 7:30PM Speaker 1, Jeffrey L Benovic, Thomas Jefferson University
“The role of GRKs in cell cycle regulation”

7:30PM – 8:00PM Speaker 2, Christina Murga, Universidad Autonoma de Madrid
“GRK-dependent regulation of cell migration”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts

8:45PM – 9:15PM Speaker 3, Lan Ma, Fudan University
“Novel functions of GRKs”

9:15PM – 9:45PM Speaker 4, Neil Freedman, Duke University
“GRK regulation of growth factor receptors”


Thursday,
June 12, 2014

7:30AM – 9:00AM Breakfast

Session 7
9:00AM – 12:15PM
Phosphorylation-independent regulation of signaling by GRKs
Stephen Ferguson, University of Western Ontario

9:00AM - 9:30AM Speaker 1, Stephen Ferguson, University of Western Ontario
“Phosphorylation-independent regulation of metabotropic glutamate
signaling by GRK2”

9:30AM –10:00AM Speaker 2, Eitan Reuveny, Weizmann Institute of Science
“Differential control of potassium channel activity by GRK2”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15AM Speaker 3, Annemieke Kavelaars, University of Texas
“The GRK2/Epac1 interface as a target to prevent chronic pain”

11:15AM – 12:00PM Speaker 4, Federico Mayor Jr., Universidad Autónoma de Madrid
“GRK2 as a node in cell signaling networks”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts

12:15PM – 12:45PM Business Meeting

12:45PM – 1:45PM Lunch

Free Afternoon

1:00PM – 6:00PM Optional Organized Group Activity

4:00PM – 6:00PM Poster Session 4 – Optional

6:00PM – 7:00PM Dinner

Session 8:
7:00PM – 9:45PM
GRK in neuronal functions II
Raul Gainetdinov, Istituto Italiano di Tecnologia

7:00PM - 7:30PM Speaker 1, Raul Gainetdinov, Italian Institute of Technology
“Regulation of dopamine signaling by GRKs: implications for related
disorders”


8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts

8:15PM – 8:30PM Break

8:30PM – 8:45PM Short Talk Selected From Submitted Abstracts

8:45PM – 9:15PM Speaker 3, Laura Bohn, The Scripps Research Institute
“GRK-related mechanisms of opiate analgesia, addiction and
tolerance”

9:15PM – 9:45PM Speaker 4, Richard L. Hauger, University of California San Diego
“Role of GRK-mediated regulation of CRF receptor signaling in
stress vulnerability ”

Friday,
June 13, 2014

7:30AM – 8:30AM Breakfast

Session 9
8:30AM – 11:30PM
GRKs in model organisms
Melanie Philipp, University of Ulm

8:30AM - 9:00AM Speaker 1, Melanie Philipp, University of Ulm
“GRK5 in symmetry breaking during organ patterning”

9:00AM – 9:30AM Speaker 2, David Hipfer, University of Montreal
“Drosophila GPRK2 regulation of Hedgehog signaling”

9:30AM – 9:45AM Short Talk Selected From Submitted Abstracts

9:45AM – 10:00AM Break

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts

10:15AM – 10:45AM Speaker 3, Wei Chen, Duke University
“Regulation of Wnt signaling via GRK phosphoryation of LRP6”

10:45AM – 11:15AM Speaker 4, Denise Ferkey, University at Buffalo-SUNY
“GRK functions in C. elegans”

11:15AM – 11:30AM Closing Comments

11:30AM Departures
Boxed Lunches Available

END OF CONFERENCE

8 Jun - 8 Jun 2014

Steamboat Springs
United States of America
meeting website