Phospholipid Cell Signaling and Metabolism in Inflammation and Cancer”

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Organizers:
Julian G. Cambronero
Wright State University
Dayton, OH

George M. Carman
Rutgers University
New Brunswick, NJ

Sunday, June 1, 2014
4:00PM – 9:00PM Conference Registration

6:00PM – 7:00PM FASEB Opening Reception

7:00PM – 8:00PM Dinner

8:00PM – 8:15PM Welcome from Organizers

8:15PM – 9:10PM Keynote Speaker-1, Charles Serhan, Harvard University
“Resolution of inflammation and infection: Role of pro-resolving
mediators”

9:10PM – 10:05PM Keynote Speaker-2, Pier Paolo Pandolfi, Harvard University
“Cancer metabolism: fatty acid oxidation in the limelight”

Monday, June 2, 2014

7:30AM – 9:00AM Breakfast

Session 1:
9:00AM – 12:00PM
Phospholipid metabolism and cell signaling
Chair, George M. Carman, Rutgers University

9:00AM - 9:30AM George M. Carman, Rutgers University
“Phosphatidate phosphatase in lipid signaling and vesicular”
trafficking”

9:30AM –10:00AM Peter Tontonoz, University of California, Los Angeles
“Regulation of phospholipid metabolism by LXRs”

10:00AM – 10:15 AM Short Talk Selected From Submitted Abstracts


10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15AM Suzanne Jackowski, St. Jude Children’s Research Hospital
“Elimination of CDP-ethanolamine-derived phospholipid alters
liver and muscle”

11:15AM – 11:45PM Bruce D. Hammock, UCD Comprehensive Cancer Center
“Omega-3 fatty acids act through their epoxides to block
angiogenesis, tumor growth and metastasis in murine
xenographs”

11:45PM – 12:00PM Short Talk Selected From Submitted Abstracts


12:00PM – 1:00PM Lunch

1:00PM – 2:00PM • Meet the Experts-1 (Dr. Peter Tontonoz UCLA; Dr. Bruce
Hammock, UCD; and Dr. Tamas Balla, NIH)


Free Afternoon

4:00PM – 6:00PM Poster Session (Even numbers)

6:00PM – 7:00PM Dinner

Session 2:
7:00PM – 9:55PM
Membrane remodeling imaging and cell migration
Chair, Pietro De Camilli, Yale University School of Medicine

7:00PM - 7:30PM Pietro De Camilli, Yale University School of Medicine
“Role of phosphoinositide metabolism in the regulation of
endocytosis”

7:30PM – 8:00PM Gregory Fairn, St. Michael's Hospital, Toronto
“Cholesterol and endocytic recycling regulate the (sub)cellular
distribution of phosphatidylserine”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts


8:15PM – 8:40PM Break

8:40PM - 9:10PM Peter Devreotes, Johns Hopkins University School of Medicine
“Propagating waves of Ras activation and phosphoinositide
production control directed cell migration”

9:10PM – 9:40PM Michael J. O. Wakelam, The Babraham Institute
“Lipid-protein biology in cellular trafficking, secretion and
migration”

9:40PM – 9:55PM Short Talk Selected From Submitted Abstracts



Tuesday, June 3, 2014

7:30AM – 9:00AM Breakfast

Session 3
9:00AM – 12:15PM
Phospholipase A2 and lipid signaling mediators
Chair, Suzanne Barbour, Virginia Commonwealth University

9:00AM - 9:30AM Suzanne Barbour, Virginia Commonwealth University
“Group VIA Phospholipase A2 in Metabolic Disease”

9:30AM –10:00AM Edward A. Dennis, University of California San Diego
“Evolution of Phospholipase A2s in catalysis and membrane
signaling”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts


10:15AM – 11:00AM • GROUP PHOTO & FASEB Sponsored Coffee Break

11:00AM – 11:30AM Sasanka Ramanadham
“Impact of iPhospholipaseA2beta-derived lipids on inflammatory
responses in islet beta-cells”

11:30AM – 12:00PM Bruce A. Freeman, University of Pittsburgh
“Nitric oxide and nitrite-mediated generation of electrophilic lipid
signaling mediators”

12:00PM – 12:15PM Short Talk Selected From Submitted Abstracts


12:15PM – 1:15PM Lunch

1:15PM – 2:15PM • Meet the Experts-2 (Dr. Walter Shaw, Avanti Polar Lipids;
Dr. Peter Devreotes, Johns Hopkins; and Dr. Faustino Mollinedo,
CSIC, Universidad de Salamanca, Spain

Free Afternoon

4:00PM – 6:00PM Poster Session (Even numbers)

6:00PM – 7:00PM Dinner

Session 4:
7:00PM – 9:55PM
Phospholipase D molecular signaling and cancer
Chair, Julian G. Cambronero, Wright State University

7:00PM - 7:30PM Julian G. Cambronero, Wright State University
“New paradigms in phospholipase D signaling in inflammation and
cancer”


7:30PM – 8:00PM Michael A. Frohman, Stony Brook University
“Phospholipase D: A triple-threat for inhibition of cancer
progression”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts


8:15PM – 8:40PM Break

8:40PM - 9:10PM David Foster, Hunter College, CUNY
“Phosphatidic acid-mediated control of mTOR survival and
proliferative signals”

9:10PM – 9:40PM Do Sik Min, Pusan National University South Korea
“The role of phospholipase D in intestinal tumorigenesis”

9:40PM – 9:55PM Short Talk Selected From Submitted Abstracts



Wednesday, June 4, 2014

7:30AM – 9:00AM Breakfast

Session 5
9:00AM – 12:00PM
Phospholipase C in inflammation, autophagy and cancer
Chair, Suzanne Scarlata, Stony Brook University

9:00AM - 9:30AM Suzanne Scarlatta, Stony Brook University
“The role of Phospholipase Cbeta in RNA interference”

9:30AM –10:00AM Lucio Cocco, University of Bologna
“Role of phospholipase C in nuclear inositide pathways and
prevention of initiation of cancer”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts


10:15AM – 10:45AM FASEB Sponsored Coffee Break

10:45AM – 11:15AM Matilda Katan-Muller, University College London
“Phospholipase C deregulation in immune disorders and cancer”

11:15AM – 11:45PM Gilbert Di Paolo, Columbia University
“Role of phospholipids in autophagy and mTOR signaling”

11:45PM – 12:00PM Short Talk Selected From Submitted Abstracts


12:00PM – 1:00PM Lunch

Free Afternoon

4:00PM – 6:00PM Poster Session (Odd numbers)

6:00PM – 7:00PM Dinner

7:00PM – 7:30PM • BUSINESS MEETING - Election of Next Chair and Site
Selection

Session 6:
7:30PM – 9:50PM
Phosphoinositide kinases
Chair, Richard A. Anderson, University of Wisconsin

7:30PM - 8:00PM Richard A. Anderson, University of Wisconsin
“Phosphoinositide regulation of receptor trafficking”

8:00PM – 8:30PM Tamas Balla, National Institutes of Health
“Studying old enigmas of the phosphoinositide-cycle with new
molecular tools”

8:30PM – 8:50PM Break

8:50PM - 9:20PM Lois Weisman, University of Michigan
“New insights into the regulation of the signaling
phosphoinositides PI3,5P2 and PI5P”

9:20PM – 9:50PM Miguel A. Iñiguez, Centro de Biología Molecular Severo Ochoa,
Madrid, Spain “Antiinflammatory effects of LXR and RXR ligands”


Thursday, June 5, 2014

7:30AM – 9:00AM Breakfast

Session 7
9:00AM – 12:15PM
Sphingolipid enzymes, inflammation and cancer
Chair, Yusuf A. Hannun, Stony Brook Cancer Center

9:00AM - 9:30AM Yusuf A. Hannun, Stony Brook Cancer Center
“Sphingomyelinases in cell regulation”

9:30AM –10:00AM Julie Saba, Children’s Hospital Oakland Research Institute
“Sphingosine-1-phosphate lyase and the sphingosine-1-
phosphate signaling axis in inflammatory bowel disease and colon
cancer”

10:00AM – 10:15AM Short Talk Selected From Submitted Abstracts


10:15AM – 10:40AM FASEB Sponsored Coffee Break

10:40AM – 11:10AM Nigel Pyne, University of Strathclyde, Glasgow
“Sphingosine-1-phosphate in health and disease”

11:10AM – 12:10PM Sarah Spiegel, Virginia Commonwealth Univ School Med
“Sphingosine-1-phosphate at the crossroads between
inflammation and cancer”

12:10PM – 1:10PM Lunch

Free Afternoon

4:00PM – 6:00PM Poster Session (Odd numbers)

6:00PM – 7:00PM Dinner

Session 8:
7:00PM – 9:55PM
Antitumor therapy; Diacylglycerol kinases signaling
Chair, Faustino Mollinedo, CSIC, University of Salamanca, Spain

7:00PM - 7:30PM Faustino Mollinedo, CSIC, University of Salamanca, Spain
“Lipid rafts and endoplasmic reticulum stress in alkylphospholipid
antitumor therapy”

7:30PM – 8:00PM Matthew Riese, Medical College of Wisconsin
“Targeting diacylglycerol kinases toward enhancing effector T cell
activity against tumor”

8:00PM – 8:15PM Short Talk Selected From Submitted Abstracts


8:15PM – 8:40PM Break

8:40PM - 9:10PM Matthew Topham, Hunstsman Cancer Institute
“Diverse signaling roles of diacylglycerol kinases”

9:10PM – 9:40PM Yasunori Kanaho, University of Tsukuba, Japan
“Diacylglycerol kinases and phospholipase D”

9:40PM – 9:55PM Short Talk Selected From Submitted Abstracts



Friday, June 6, 2014

7:30AM – 8:30AM Breakfast

9:00AM Departures
Boxed Lunches Available

1 Jun - 1 Jun 2014

Niagara Falls
United States of America
meeting website