Tumour Microenvironment and Signalling

Many oncogenes and tumour suppressor genes have been identified and mapped to signaling pathways that regulate cell growth and death. Dysregulation allows oncogenes and tumour suppressor genes to transform mammalian cells and cancers arise in conditions where multiple such events occur in the same cell. It has also been found that a subset of the cells present in a tumour, called cancer stem cells, retain the ability to self-renew and to give rise to all cell types in a particular cancer.

An emerging concept is that tumours also strongly depend on external signals for maintenance and expansion. To fully understand tumour development and progression, a deeper knowledge of the cross-talk between tumour cells and their microenvironment and the interactions between cancer cells and cancer stem cells is needed.

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Speakers

Confirmed Speakers

Kari Alitalo
Kari Alitalo
University of Helsinki, Finland


Frances Balkwill
Barts Cancer Institute, United Kingdom


Mariano Barbacid
Spanish National Cancer Research Centre, Spain

Eduard Batlle
Eduard Batlle
Institute for Research in Biomedicine (IRB), Spain


Joanne Brugge
Harvard Medical School, USA

Vincenzo Cerundolo
Vincenzo Cerundolo
University of Oxford, United Kingdom


Mike Clarke
Stanford University, USA


Maria Pia Cosma
CRG Barcelona, Spain

Bruce Edgar
Bruce Edgar
German Research Center (DKFZ), Gremany


Mikala Egeblad
Cold Spring Harbor Laboratory, USA

Rudolf Grosschedl
Rudi Grosschedl
Max Planck Institute of Immunobiology and Epigenetics, Germany


Lisa Johnson
BC Cancer Agency, Canada


Jos Jonkers
Netherlands Cancer Institute, The Netherlands


Chris Marshall
The Institute of Cancer Research, United Kingdom

Jan Paul Medema
Jan Paul Medema
Academic Medical Center, The Netherlands


Luis Parada
UT Southwestern, USA

Emmanuelle Passegué
Emmanuelle Passegué
UCSF, USA

Catrin Pritchard
Catrin Pritchard
University of Leister, United Kingdom


Andreas Trumpp
German Cancer Research Centre (DKFZ), Germany


Terry van Dyke
National Cancer Institute, USA


Karen Vousden
The Beatson Institute for Cancer Research, United Kingdom


Zena Werb
University of San Francisco, USA

7 May - 10 May 2014
heidelberg
Germany
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