Lipoprotein metabolism

The Gordon Research Conference on Lipoprotein Metabolism is one of the longest standing conferences in the 80 year history of the GRC. The scientific content of our conference has continually evolved since the first meeting and, traditionally, is considered the preeminent forum in our discipline for the presentation of high impact leading edge science. The program for the 2012 Conference on Lipoprotein Metabolism will communicate new and exciting advances in the field and will bring together a range of established investigators, new investigators, and trainees from around the world to present and discuss a spectrum of topics related to new developments in lipid and lipoprotein metabolism, particularly in those areas that impact upon human disease. Basic molecular and cell biological studies, animal models of metabolism, and genetic studies in humans will be presented. Topics include the structural and functional diversity of HDL; cholesterol efflux and ABC transporters; cellular sterol trafficking and lipid droplet biology, alternate functions of LDL receptor family members and recent advances in therapy to treat dyslipidemia and cardiovascular disease. Novel mechanisms of plasma cholesterol homeostasis, genetic determinants of plasma lipids and the use of metabolomics and proteomics to study lipid and lipoprotein metabolism will also be featured. In addition to outstanding leading-edge lectures and discussion, poster presentations represent an integral part of the scientific program. Additional Oral Sessions will be selected from among submitted abstracts.
+ show speakers and program
2:00 pm - 9:00 pm Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by GRC Site Staff
7:40 pm - 9:30 pm The Control of Lipolysis in Plasma
Discussion Leader: Stephen G. Young (UCLA)
7:40 pm - 8:00 pm Stephen G. Young (UCLA)
"New insights into lipolysis of triglyceride-rich lipoproteins"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:30 pm Ira Goldberg (Columbia University)
"Taking lipid imbalance to heart"
8:30 pm - 8:40 pm Discussion
8:40 pm - 8:55 pm Gunilla Olivecrona (Umea University)
"Post-translational modulation of lipoprotein lipase"
8:55 pm - 9:05 pm Discussion
9:05 pm - 9:20 pm Murray Huff (University of Western Ontario)
"Prevention of VLDL overproduction, dyslipidemia, insulin resistance, inflammation and atherosclerosis by citrus flavonoids"
9:20 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Regulation of Cholesterol Homeostasis
Discussion Leader: Jay Horton (UT Southwestern)
9:00 am - 9:30 am Margrit Schwarz (Amgen)
"PCSK9 inhibitors for LDL-C lowering"
9:30 am - 9:40 am Discussion
9:40 am Group Photo / Coffee Break
10:30 am - 10:50 am Kathryn J. Moore (NYU)
"MicroRNA regulation of lipoprotein metabolism"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Peter Tontonoz (UCLA)
"Nuclear receptor control of cholesterol homeostasis"
11:20 am - 11:30 am Discussion
11:30 am - 11:50 am Marisa Wong Medina (CHORI)
"Alternative Splicing in Regulation of Cholesterol Homeostasis"
11:50 am - 12:00 pm Discussion
12:00 pm - 12:20 pm Russell Debose-Boyd (UT Southwestern)
"New players in the sterol-regulated HMG CoA reductase degradation pathway"
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm High-density Lipoprotein: Impact of Particle Diversity
Discussion Leader: Mary Sorci-Thomas (Wake Forest University)
7:30 pm - 7:50 pm Mary Sorci-Thomas (Wake Forest University)
"Structure of Nascent HDL:Cholesterol and Sphingomyelin Content Reflects Importance of ApoA-I Plasticity in Regulating Cholesterol Efflux"
7:50 pm - 8:00 pm Discussion
8:00 pm - 8:20 pm Sean Davidson (University of Cincinnati)
"Apolipoprotein interactions within HDL particles"
8:20 pm - 8:30 pm Discussion
8:30 pm - 8:50 pm Jay Heinecke (University of Washington)
"Pathways for the generation of dysfunctional HDL"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Daisy Sahoo (Medical College of Wisconsin)
"BiFC-FRET: Progress on a novel method to visualize SR-BI oligomerization in vivo"
9:20 pm - 9:30 pm Discussion
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Apolipoprotein B and TG Rich Lipoprotein Assembly
Discussion Leader: Henry Ginsberg (Columbia University)
9:00 am - 9:30 am Zemin Yao (University of Ottawa)
"Lumenal lipid droplets as the determinant of VLDL secretion and microsome stress"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Edward Fisher (NYU School of Medicine)
"Regulation Of Vldl Secretion: Roles Of Insulin And Cholesteryl Ester Hydrolysis"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
11:10 am - 11:40 am Gregory Shelness (Wake Forest School of Medicine)
"Dynamics of apoB-dependent lipid mobilization and transport"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm TBA
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Expanding Functions of LDL Receptor Family Members
Discussion Leader: Joachim Herz (UT Southwestern)
7:30 pm - 8:10 pm Joachim Herz (UT Southwestern)
"Signaling through LRP-1 protection from atherosclerosis"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Bart Williams (University of Michigan)
"Assessing the Roles of Lrp5 and Lrp6 in Development and Disease"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Petra May (University of Freiburg,Germany)
"The LDL receptor-related protein 1 functions as a signaling receptor in inflammation and development"
9:20 pm - 9:30 pm Discussion
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm Lipids, ABC Transporters, and Disease
Discussion Leader: Yves Marcel (University of Ottawa)
9:00 am - 9:20 am Elizabeth Tarling (UCLA)
"New insights into the role of ABCG1 in sterol homeostasis and lipid oxidation"
9:20 am - 9:30 am Discussion
9:30 am - 9:50 am Alan Tall (Columbia University)
"The role of ABC transporters in regulating hematopoietic stem and progenitor cell proliferation, monocytosis, thrombocytosis and atherosclerosis"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:50 am John Parks (Wake Forest University)
"Tissue-specific roles of ABCA1 in lipoprotein metabolism and atherosclerosis"
10:50 am - 11:00 am Discussion
11:00 am - 11:20 am Cheryl Wellington (University of British Columbia)
"Lipoprotein Metabolism in the Central Nervous System"
11:20 am - 11:30 am Discussion
11:30 am - 12:15 pm Ira Tabas (Columbia University)
"Lipids, ER stress, and mitochondrial dysfunction in atherosclerosis"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm Advances in Therapy to Treat Cardiovascular Disease
Discussion Leader: Daniel J. Rader (University of Pennsylvania)
7:30 pm - 8:00 pm Daniel J. Rader (University of Pennsylvania)
"Functional validation of new genes associated with plasma lipoproteins"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:50 pm Andrew S. Plump (Merck)
"Advances in Novel Cardiovascular Drug Discovery"
8:50 pm - 9:00 pm Discussion
9:00 pm - 9:20 pm Roger Newton (Esperion)
9:20 pm - 9:30 pm Discussion
THURSDAY
7:30 am - 8:30 am Breakfast
8:30 am - 9:00 am Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair
9:00 am - 12:30 pm Intracellular Lipid Transport and Lipid Droplet Biology
Discussion Leader: Robert Farese, Jr. (Gladstone Institute, UCSF)
9:00 am - 9:30 am Tobias Walther (Yale University)
"Cell Biology of Cellular Fat Synthesis and Storage"
9:30 am - 9:40 am Discussion
9:40 am - 10:10 am Jean Schaffer (Washington University)
"Small nucleolar RNAs as mediators of lipid metabolic stress"
10:10 am - 10:20 am Discussion
10:20 am Coffee Break
11:10 am - 11:40 am Meng Wang (Baylor College of Medicine)
"Modeling lipid dynamics via label-free stimulated Raman scattering microscopy"
11:40 am - 11:50 am Discussion
11:50 am - 12:20 pm TBA
12:20 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 6:00 pm Poster Session
6:00 pm Dinner
7:30 pm - 9:30 pm State of the Art: Genomics, Proteomics and Metabolomics
Discussion Leader: Philippa Talmud (University College London)
7:30 pm - 8:00 pm Robert Hegele (University of Western Ontario)
"Complex genetics of hypertriglyceridemia"
8:00 pm - 8:10 pm Discussion
8:10 pm - 8:40 pm Christopher R. McMaster (Dalhousie University)
"Using High-thoughput Synthetic Genetics to Integrate Phospholipid Metabolism with Regulation of Cellular Processes"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:20 pm Chris Newgard (Duke University)
"Metabolomics used for defining metabolic disease mechanisms"

17 Jun - 22 Jun 2012
Waterville Valley
United States of America
meeting website